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Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation and suppresses skin inflammation.

New paper from Kaplan Lab. Agonizing a specific glutamate receptor on mast cells in the skin renders them less function and can suppress several models of skin inflammation. Congrats to Youran Zhang and all co-authors. #skinimmunology #immunology #mastcells www.science.org/doi/10.1126/...