Decoding m6A mRNA methylation by reader proteins in liver diseases

This review summarizes #m6A reader proteins in #LiverDisease, highlighting their roles in #RNAmetabolism, disease progression, & therapeutic potential, while emphasizing the promise of #SmallMoleculeInhibitors targeting reader–mRNA interactions.
#OpenAccess: doi.org/10.1016/j.ge...

💊New article in @drugsincontext.bsky.social

Apremilast in osteoarthritis: exploring its therapeutic mechanisms

Rafiei et al.

www.drugsincontext.com/apremilast-i...

@medsky.social @me.pharmsky.app #osteoarthritis #smallmoleculeinhibitors #rheumatology

💡Online now - the Spotlight "Drug ubiquitination: an unwelcome mode of action or a novel modality" from Richard de Heiden and Monique Mulder.

#NonCanonicalUbiquitination #Therapeutics #SmallMoleculeInhibitors

Read t it here: authors.elsevier.com/a/1m0Rm3S6Gf...

Therapeutic strategies targeting SREBP transcription factors Mechanism of action underlying SREBP in different diseases and its targeted inhibition for disease prevention and treatment.

This review summarizes the recent findings of #SREBPs mainly in terms of physiologic activation processes, regulatory processes, related diseases, and publicly available #SmallMoleculeInhibitors with #therapeuticpotential.

#OpenAccess: amm-journal.org/index.php/20...

#medsky #medicalresearch

Gilead and LEO Pharma partner to develop oral STAT6 program - PharmaTimes Companies aim to provide new treatments for inflammatory conditions

#GileadSciences #LEOPharma #strategicpartnership #drugdevelopment #atopicdermatitis #asthma #COPD #dermatology #skindiseases #respiratory #smallmoleculeinhibitors #targetedproteindegraders #STAT6pathway #oralSTAT6products #topicalSTAT6products
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