#Atropisomeric architectures are rising stars in chiral ligand & organocatalyst design! This #Synpacts by Li Long & co-workers highlights recent advances in Au-catalyzed diazo–alkyne #annulation, a powerful route to axial chirality✨
#gold #catalysis
👉 buff.ly/CcN6eyk
💡 Shining new light on enantioselective protonation/ #deuteration ⚗️ In this #Synpacts article, Ban & Jiang unveil a photochemical boron-migration strategy enabling precise construction of tertiary C–H stereocenters under chiral H-bonding #catalysis 🌞
👉 buff.ly/nSlF4jg
Tackling the challenge of γ-lactams with chiral α-quaternary carbons! This #Synpacts article by Mengchun Ye & co-workers highlights asymmetric ring decoration & TM-catalyzed carbonylative cyclization, plus future directions🚀
#lactams #catalysis
👉 buff.ly/PGx50Dq
📢📜In this #Synpacts (@synlettjournal.bsky.social), we showcase how electrosynthesis enabled the design of innovative diastereo- and enantioselective alkene 1,2-difunctionalization reactions. These contributions have inspired a complementary “Sew & Cut” strategy
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#Alkene radical anions in the spotlight🧪 In this #Synpacts article, Polyzos & co-workers highlight advances in C(sp³)–C(sp³) bond formation via #photoredox & #electrosynthesis 🔋 Featuring electroreductive alkene–aldehyde coupling enabled by rapid alternating polarity⚡
👉 buff.ly/uarxdeA
From classical methods to a dynamic kinetic strategy, Wang & co-workers showcase how #aziridines can be activated with precision✨Their radical–polar crossover (4+3) #cycloaddition unlocks diverse azepines & new paths for N-containing targets 🧪
#synpacts
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Iron-catalyzed & 1,2-cis selective #glycosylation for aminoglycoside synthesis⚡ Broad scope, reiterative use & scalable to multigrams! Mechanistic insights reveal a unique atom-transfer strategy in our #Synpacts by Hao Xu & co-workers
#iron #catalysis
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In our #Synpacts by Qiqige Qiqige & Zhaobin Wang, #chromium #catalysis transforms gem-dihaloalkanes into chiral #cyclopropanes with high stereo-control & up to 3 contiguous stereocenters.
👉 buff.ly/m4MwnXW
Our latest #synpacts from Dmitry Katayev & co-workers introduces a novel dual-functional group transfer reagent for efficient #dihalogenation, enabling a rare selective bromo-chlorination via a unique redox catalytic cycle with a radical 1,2-halogen shift🤯
👉 buff.ly/b9Rcwei
Explore the fascinating world of cyclic imine-BF₃ complexes and discover the latest developments in their use for synthesizing functionalized amines and azacycles! No more cryogenic temperatures needed in our #Synpacts by Bhatt & Seidel!
#boron
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Dive into #isotopically labeled compounds! Our new #Synpacts article by Zhang & Shi highlights a pH-dependent D₂O hydrogen-isotope-exchange process for α-deuterated alkyl #thianthrenium salts, enabling versatile #nickel catalyzed reactions.
#deuterium
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🔬Radical/palladium #RelayCatalysis has sparked a wave of C–H bond functionalization research. In this #Synpacts by Huang, vital molecules like arylacetic acids & β-lactams can be prepared from simple feedstocks. #carbonylation
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Dive into the fascinating world of enantioselective synthesis and explore the latest: achieving high stereocontrol in #alkenylboronate reactions with activated heterocycles and allylic carbonates in our #Synpacts by Tran and Ready🧪
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Uncover the fascinating world of #SiliconSwitch!🔍Our #synpacts article by Dominic Willcox explores the latest developments in syntheis of complex silyl heterocycles using 1,1-carboboration.
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