#targetengagement hashtag - Bluesky

@promegauk.bsky.social

2 months ago

TarSeer™ BRETSA™ measures target engagement for difficult proteins in live cells via thermal stability. Addresses weak binders & targets lacking probes.

Practical drug discovery tool. SLAS 2026.

https://ow.ly/Rj2G50YcPTt

#DrugDiscovery #TargetEngagement

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Promega UK

@promegauk.bsky.social

7 months ago

Tivantinib entered trials as a MET inhibitor, then turned out to act through another mechanism.

This blog explores why confirming cellular target engagement is essential in drug discovery

👉https://tinyurl.com/TivantinibBlog

#DrugDiscovery #TargetEngagement

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Dr. Herbert Loong

@herbloongmd.bsky.social

11 months ago

Thanks my #coinvestigators for opportunity to present data of #D3S_001, a novel #KRASG12C inhibitor in #G12Ci pre-treated #NSCLC at @theaacr.bsky.social #AACR25. Strong & rapid #targetengagement confer superior #efficacy c.f. 1st generation G12Ci.

✔️ORR 30%; DCR 80% in KRASG12Ci pre-treated popn.

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