We also cover the increasingly promising attempts to exploit the properties of #tissueTregs in the clinic, and outline the key open questions for the field. We are really privileged to be tackling some of these questions in the lab right now, thanks to @erc.europa.eu and @wellcometrust.bsky.social.
The cellular kinetics are not fully understood, however the majority of evidence using parabiosis, TCR retrogenics, cell transfers and fate-mappers suggest that the majority of #tissueTregs are pan-tissue, multi-tissue or tissue-cycling in their behaviour during homeostasis.
#TissueTregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues.
Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field
www.annualreviews.org/content/jour...
For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!)
www.youtube.com/watch?v=o_X4...
It starts with a large multi-tissue multi-timepoint parabiosis experiment we ran to understand #TissueTregs (link below).
Václav Gergelits, resident mathematician, saw greater potential in this dataset to understand the kinetics of lymphocyte migration broadly. 2/10
www.cell.com/immunity/ful...
