An Estrogen Receptor β Agonist with AR Antagonist Activity from a Modern Asymmetric De Novo Steroid Synthesis While the androgen receptor (AR) has long been a molecular target of prostate cancer therapeutics, the estrogen receptor β (ERβ) has more recently become of interest in this area of chemotherapeutic s...

The oestrogen receptor β (ERβ) is a promising drug target for #tumoursuppression.

In #ACSMedChemLett, Bucknam et al. describe the power of modern asymmetric de novo synthesis of estranes to identify potent and selective agonists of ERβ

pubs.acs.org/doi/10.1021/...