Multi‑panel figure illustrating effects of reducing mutant huntingtin in striatal somatostatin interneurons (SST‑INs). (A) Diagram of AAV9‑SST‑eGFP injection site in the mouse striatum for control, BACHD, and BACHD/SST‑Cre genotypes. (B) Confocal images show SST‑INs expressing eGFP (green) and SST immunolabeling (red), confirming targeted expression; nuclei in blue; 10 µm scale bar. (C) Scatter/violin plot shows higher spontaneous firing rates in BACHD SST‑INs compared with controls, with firing normalized in BACHD/SST‑Cre mice; points indicate mice and lines the median. (D) Example color‑coded traces of spontaneous firing. (E) Cumulative distributions of inter‑event intervals show increased inhibitory synaptic event frequency in BACHD/SST‑Cre SST‑INs. (F) Cumulative distributions of inhibitory postsynaptic current amplitudes show reduced amplitudes in BACHD mice and normalization in BACHD/SST‑Cre mice. (G) Example inhibitory synaptic current traces. (H) Amplitude–frequency histograms
In a new paper, Jahmel Fowler, Michelle Gray & co show that mutant huntingtin expression in somatostatin-expressing interneurons contributes to anxiety-like behavior in male mouse model of #HuntingtonsDisease
doi.org/10.1242/dmm....
#UABMedicine
