Person functionally cured of HIV after bone marrow transplant from sibling A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to

Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence Aw, D., Silva, A. B. & Palmer, D. B. Immunosenescence: emerging challenges for an ageing population. Immunology 120, 435–446 (2007). Peters, M. J. et al. The transcriptional landscape of age in human peripheral blood. Nat. Commun. 6, 8570 (2015). Goronzy, J. J. & Weyand, C. M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 14, 428–436 (2013). Huang, Z. et al. Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis. Proc. Natl Acad. Sci. USA 118, e2023216118 (2021). Luo, O. J. et al. Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty. Nat. Aging 2, 348–364 (2022). Mogilenko, D. A. et al. Comprehensive profiling of an aging immune system reveals clonal GZMK+ CD8+ T cells as conserved hallmark of inflammaging. Immunity 54, 99–115 (2021). Terekhova, M. et al. Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells. Immunity 56, 2836–2854 (2023). Carr, E. J. et al. The cellular composition of the human immune system is shaped by age and cohabitation. Nat. Immunol. 17, 461–468 (2016). Gong, Q. et al...

Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence
->Nature | More on "Aging immune system sex differences" at BigEarthData.ai

For researchers: a useful list of techniques to sharpen your googling.

h/t @alondra.bsky.social

#skystorians #histsci #histmed #histtech

Structural adaptations for enhanced translation kinetics in evolved ribosomes pubmed.ncbi.nlm.nih.gov/41846938/ #cryoEM

Masked mitochondria slip into cells to treat disease in mice Transplantation technique lengthened survival in animals with an often-fatal mitochondrial disease.

These 'disguised' mitochondria prolonged the life of mice with a deadly disease caused by abnormal mitochondria

go.nature.com/4sllys0

Postdoctoral Research Associate at The University of Edinburgh Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

Like #hemocytes? I'm advertising a 3 year, BBSRC #postdoc position, in #Edinburgh, using #Drosophila & human cells to understand sex differences in the regulation of #macrophage function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.jobs.ac.uk/job/DQU604/p...

Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantation Functional reconstitution of the endometrium occurs after both uterus and HSC transplantation, and male immune cells can replenish the uterine niche.

How does the uterine immune system recover after transplant?

A team in #ScienceTranslationalMedicine studies uterine transplant and stem cell transplant recipients and shows that all immune cell lineages reconstitute despite a drop in NFAT signaling. https://scim.ag/4bqtzEL

Ageing promotes metastasis via activation of the integrated stress response @nature.com
www.nature.com/articles/s41...

Ribosome Molecular Aging Shapes Translation Dynamics
www.biorxiv.org/content/10.6...

CAR-T therapy provides relief for children with autoimmune diseases Symptoms and organ damage abated in young children and teenagers whose conditions had resisted other treatments.

CAR-T cell therapy seems to have reset the immune system and eased severe symptoms in eight children and adolescents with autoimmune disorders

go.nature.com/3OkkANp

Ribosome biogenesis and homeostasis: in the front line to cope with cellular stress Cells must continuously adapt to both internal and environmental stresses by finely tuning their molecular and metabolic activities. One of the most r…

Fascinated by how cells adapt to a plethora of stimuli?

​This review describes how cells use and modulate #ribosomes to cope with stresses. We discuss the central role of ribosome-associated processes in #cellplasticity, #signaling, #geneexpression and #diseases 🕹

@cbitoulouse.bsky.social

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

The ageing immune system as a driver of systemic ageing Nature Reviews Immunology, Published online: 13 February 2026; doi:10.1038/s41577-026-01269-3Ageing of the immune system is now realized to drive systemic ageing, and there is interest in targeting immune ageing in order to promote healthy ageing. Here, the authors detail how ageing affects different immune cell populations and discuss strategies to rejuvenate the immune system in order to extend healthspan.

ICYMI: The ageing immune system as a driver of systemic ageing

What if the blood system was a cornestone of healthy aging?
Excited to share our last review "Hematopoietic (stem) cells - the elixir of life?" exploring the potential of blood cells to counteract organismal aging!🩸

@febsletters.bsky.social
@hilife-helsinki.bsky.social
@helsinki.fi
@ki.se

👻🎃 Can you spot Waldo among the skeletons? 💀👀 @helsinki-biotech.bsky.social
Halloween Party 🥳 thanks for the great time!