FDA

That was quick!

The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA

www.fda.gov/drugs/novel-...

#NephSky

#TopNephrology

A previously healthy man presented with a 10-day history of blood dripping from one nostril. Twenty days earlier, he had washed his face with mountain spring water. A leech was found on nasal endoscopy (shown in a video). Read the full case details: nej.md/3J6IZUD

#MedSky #Otolaryngology

Dr. Asaf Bitton, a primary care physician and professor, talks about valuing the critical role of primary care docs.

Hear more in the first episode of Not Otherwise Specified season 3, hosted by NEJM National Correspondent Dr. Lisa Rosenbaum: nej.md/3W416gK

#MedSky

Black & white photo of a man measuring the blood pressure of another man

lol, people measuring BP incorrectly since, (at least), 1881, 👀😳🤦🏼‍♀️😅😂 #hypertension

cc: Dr. @drjmluther.bsky.social - for your photos 🤓😃😂

#NephSky

Climate change represents a threat to kidney health, particularly in pediatrics, where children are more vulnerable to heat injuries & environmental toxins. Read this Review of green nephrology: environmentally sustainable kidney care in pediatrics.
link.springer.com/article/10.1...

Day 1️⃣ of the SEISMIC C3G and IC-MPGN focused on improving the future for those affected by C3G and IC-MPGN. Highlights include the urgency to accelerate diagnosis and treatment, alongside the significance of biomarkers and centers of excellence. Today's insights were powerful💥.

Pegcetacoplan Benefits Patients With C3G/IC-MPGN and Nephrotic Proteinuria | Docwire News An analysis confirmed the efficacy and safety of pegcetacoplan for patients with C3 glomerulopathy and primary immune complex membranoproliferative and nephrotic range proteinuria.

An analysis confirmed the efficacy and safety of #pegcetacoplan for patients with C3G/IC-MPGN and nephrotic range #proteinuria. #C3G #ICMPGN #kidneydisease #nephrology #nephsky www.docwirenews.com/post/pegceta...

A multicenter prospective cohort study evaluating impact of an active delisting strategy to enable kidney transplantation in wait-listed candidates with calculated Panel Reactive Antibody ≥ 99.9%

doi.org/10.1016/j.kint.2025.04.031

#NephSky #MedSky #kidneytransplantation

¿TAC o MMF en el síndrome nefrótico pediátrico? — NephJC El ensayo STAMP comparó ambos tratamientos en niños con recaídas frecuentes o corticodependencia. ¿Cuál fue más eficaz? ¿Qué tan seguros son? 🖼️ Revisa el VA completo #NephJC

El ensayo STAMP comparó ambos tratamientos en niños con recaídas frecuentes o corticodependencia.
¿Cuál fue más eficaz? ¿Qué tan seguros son? #NephJC
VA by @dramiliflores.bsky.social
www.nephjc.com/news/2025/6/8/tac-o-mmf-en-el-sd-nefrotico-pediatrico

Evaluation of Methodologies in Anti-nephrin Autoantibody Detection

doi.org/10.1016/j.kint.2025.05.018

#OpenAccess #MedSky #NephSky #fsgs #focalsegmentalglomerulosclerosis #minimalchangedisease

Uncontrolled diabetes mellitus (DM) accelerates atherosclerosis & vascular diseases. Read this Original Article on serum sclerostin as a marker of micro- & macrovascular complications among children & adolescents w/type 1 DM. Open Access.
link.springer.com/article/10.1...

EU Approves Sparsentan for Treatment of IgAN | Docwire News The European Commission has granted standard approval to sparsentan for the treatment of adults with primary IgA nephropathy (IgAN).

Sparsentan is now approved for the treatment of IgAN in European Union countries. #igan #iganephropathy #kidneydisease #nephrology #nephsky www.docwirenews.com/post/eu-appr...

AKI commonly occurs in critically ill children, but its impact on pediatric growth outcomes has been sparsely described. Read this Systematic Review /Meta-analysis comparing growth in children w/a history of AKI to those w/o AKI. Open Access
link.springer.com/article/10.1...

Fibroblast growth factor (FGF) 23 and FGF receptor 4 induced cardiac mitochondrial dysfunction as a new target in #CKD?

doi.org/10.1016/j.kint.2025.02.017

Original article: doi.org/10.1016/j.kint.2025.01.024

#KICommentary #MedSky #NephSky #chronickidneydisease

Read these Clinical Insights into a 17-yr-old male who developed AKI w/cast nephropathy following a 6-day high-dose creatine loading regimen. This case highlights the risks of high-dose creatine use.
link.springer.com/article/10.1...

Thrombotic microangiopathy following scorpion envenomation

doi.org/10.1016/j.kint.2024.10.033

#KINephrologyImage #NephSky #MedSky #SkyNeph

Glomerular diseases are a leading cause of CKD worldwide. Read this Review of monogenic podocytopathies & mechanisms by which single-gene defects lead to podocyte injury & glomerulosclerosis. Free access this month.
bit.ly/4cUA5Us

The erythropoietin resistance index (ERI) is an indicator of erythropoietin (EPO) resistance & is related to a worse prognosis in patients on hemodialysis (HD). Read this Original Article on EPO resistance in children w/kidney failure on HD. Open Access.
link.springer.com/article/10.1...

Nocturnal enuresis (NE) is a socially stigmatizing & stressful childhood condition. Read this Systematic Review/ Meta-Analysis assessing the efficacy of multiple drugs in pediatric NE through a network meta-analysis (NMA).
link.springer.com/article/10.1...

DSA testing isn’t the whole story.
Routine assays detect HLA class I & II antibodies — but miss others.
🔍 AMR can involve non-HLA targets:
AT1R, ETAR, MICA, Collagen I/V, K-α tubulin, and more.
Result? “False negative” DSA in patients with real immune injury. #NephJC

pmc.ncbi.nlm.nih.gov...

Analysis of the prespecified FIDELITY pooled patient dataset examined the efficacy and safety of #finerenone in patients with an acute change in #estimatedglomerularfiltrationrate

doi.org/10.1016/j.kint.2025.03.018

#OpenAccess #MedSky #NephSky #kidney #eGFR

Accurate assessment of kidney function is essential in treating pediatric patients dosed w/nephrotoxic chemotherapy. Read this Original Article comparing GFR estimation equations using creatinine, cystatin C, & their combination in pediatric hematology–oncology.
link.springer.com/article/10.1...

Glucocorticoid Exposure and Infection in Children and Adults With Glomerular Disease: Findings From the Cure Glomerulonephropathy Study

bit.ly/3DHbXai (FREE)

Alport Syndrome (AS) is a genetic disorder affecting type IV collagen, leading to hearing loss, eye problems & progressive CKD. Read this Research Letter on results of a European Society of Paediatric Nephrology survey to assess awareness of guidance for AS.
link.springer.com/article/10.1...

Several case reports describe new onset or relapsed NS after COVID-19 mRNA vaccination, but there have been no systematic studies in children. Read this Original Article on the association of COVID-19 vaccination w/relapsed NS & new onset NS in children.
link.springer.com/article/10.1...

Kidney disease is a worldwide killer. Treat it that way The international community has a golden opportunity to start reining in the escalating, mostly ignored global burden of chronic kidney disease.

Kidney disease should be recognised on WHO's priority list of non-communicable diseases, alongside cancer, cardiovascular disease, and diabetes

https://go.nature.com/4lLJ5iY

#Kidney dysfunction and nephromegaly related to kidney Aichi virus infection

doi.org/10.1016/j.kint.2024.09.025

#KINephrologyImage #OpenAccess #NephSky #MedSky #nephrology

Examination of the urinary sediment is an important non-invasive tool for diagnosis & surveillance of kidney diseases. Read this Educational Review of collecting & examining urine samples in order to obtain reliable results. Free access this month.
bit.ly/3DYRNcx

Persistent proteinuria is an independent risk factor for poor prognosis in immunoglobulin A vasculitis nephritis (IgAVN). Read this Original Article on telitacicept efficacy & safety in reducing proteinuria for refractory childhood IgAVN.
link.springer.com/article/10.1...

Somatic mutations acquired during life: state of the art and implications for the #kidney

doi.org/10.1016/j.kint.2024.10.036

#KIMiniReview #NephSky #MedSky #kidneybiopsy