Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

Pancreatic cancer mRNA vaccine shows lasting results in an early trial Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

This program transformed my career! Please apply.

@hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen

A job posting flyer from the Department of Bacteriology at the University of Wisconsin-Madison advertising a Teaching Faculty II position. The role involves coordinating and teaching microbiology lab courses and/or large enrollment introductory classes. The application deadline is May 5, 2026, at 11:59pm CDT. Applications must be submitted electronically via the Jobs at UW portal; emailed applications are not accepted. Applicants must upload a single document containing a cover letter, CV, and teaching philosophy. The job listing URL is https://jobs.wisc.edu/jobs/teaching-faculty-ii-madison-wisconsin-united-states, Job ID JR10009916. The flyer notes that Madison, Wisconsin is described as a vibrant place to live and work, combining college-town energy, lakeside scenery, and a community-focused atmosphere.

Interested in a teaching faculty position in Bacteriology at UW-Madison? See the attached announcement! @uwbact.bsky.social

New preprint from the Vecchiarelli Lab! 🧵

Congratulations to first author Dr. Claire Dudley!
@claire-dudley.bsky.social

Claire uncovered a critical player in the organization for the photosynthetic cytoplasm of cyanobacteria - polyphosphate! #polyP

www.biorxiv.org/content/10.6...

NSF GRFP results are out!
Awardees: docs.google.com/spreadsheets...

Honorable Mention: docs.google.com/spreadsheets...

(Our team members didn't get emails but discovered the lists through Reddit. Confirmed by logging in to the website and checking.)

#NSF #GRFP

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

Announcing Seattle DROP: Discover Research Opportunities for Postdocs on May 5th

Interested in postdoc opportunities in Seattle, WA? Seattle DROP is a virtual biomedical postdoc recruitment event sponsored by @fredhutch.org, @uwnews.uw.edu, and @seattlechildrens.org on May 5th from 8 AM-1 PM PT.

Based on that, we compare chemigenetic labels, HALOtag9 and fSNAPtag, as well as mStayGold variants in tissue culture.

In our hands, the mStayGold variants show higher useable brightness than these particular chemigenetic labels. mStayGold2 shows highest useable brightness.

Mirror mirror on the wall who is the brightest of them all?

Brightness is a key parameter for choosing fluorescent reporters in bioimaging. As tricky to assess, we present a pipeline to compare chemigenetic labels and FPs in tissue culture and #zebrafish embryos.

www.biorxiv.org/content/10.6...

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: tRNA synthetase activity is required for stress granule and P-body assembly
By Baymiller et al. and Stephanie Moon
➡️ genesdev.cshlp.org/content/early/2026/01/13...

Stephanie Moon
#translation #ribosome #granule #stress

Graduate and Professional Student Appreciation Week UW–Madison celebrates with events, recognition for students, and awards.

It's Graduate and Professional Student Appreciation Week, and we thank students for their contributions!

Many @uwmadison.bsky.social inventions start as @uwmadgsed.bsky.social student research. From the lab to the marketplace, grad students play a vital role in translating discovery into impact.

Wrapping up the semester with our last RNA Maxigroup talk featuring Blake Wiedenheft! Thanks to @bmolchem.bsky.social @uwbiochem.bsky.social and @rnasociety.bsky.social for sponsoring!

Linked in post from Sarah Bray The Company of Biologists (known for its 5 journals, Development, Journal of Cell Science, Journal of Experimental Biology, Disease Models and Mechanisms, Biology Open, as well as its charitable activities) is looking to appoint a new CEO. An opportunity to guide the next chapter! More information here:

The Company of Biologists @biologists.bsky.social has a more than 100 year history of supporting science through its journals, meetings, and fellowships. Help lead it into its second century! pls share
www.inspiredselection.com/jobs/jo00000...

45 novel protein folds in the updated AFESM (AFDB + ESMatlas) manuscript:
• 12 high-confidence folds in AFESM
• 33 by ColabFold-repredicting 2.3M low-quality domains
We show AFDB captures most domains already and ESMfold struggles with novelty
🌏 afesm.foldseek.com
📄 biorxiv.org/content/10.1...

🎉 Congrats to 2026 Thomas Hunt Morgan Medal recipient Judith Kimble of @uwbiochem.bsky.social! Her work has built an entire field and inspired generations of scientists through her mentorship and leadership.

🔗Read more: buff.ly/0yzHXvk

Congratulations to the legendary scientist Judith Kimble!!!

We stand on the shoulders of giants.

#womeninSTEM #celegans

Machines on Genes 2026
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷

Two deadlines coming up on 8 April 2026

i. abstract submission
ii. early bird submission (save €50)

Four days of 🧑‍🔬🧬👩‍🔬☀️👨‍🔬🔬❄️🧪🧫

94th Harden Conference by @lapassmore.bsky.social, Dana Branzei, me with @biochemsoc.bsky.social.

AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network Nature Methods - ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray...

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH
Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway - The EMBO Journal Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism deployed in embryonic stem cells and cancer cells. High levels of the heterochromatin mark H3 lysine 9 trimethylation (H3...

Association of orphan nuclear receptors and heterochromatin are involved in Alternative Lengthening of Telomeres – Liuh-Yow Chen and coworkers identify their link as the transcriptional corepressor TRIM28
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...

The University of Waterloo is seeking internationally renowned scholars, especially those working in #CryoEM, for the prestigious Canada Impact+ Research Chairs program- Chairs receive long-term funding & institutional support - Learn More zurl.co/JBfJ9

Congratulations to Ahmad and the rest of the authors!!!

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

Congratulations to Kelly and all authors from the Nguyen, Wellinger, and Chartrand labs! Another milestone in the telomerase structural biology field!

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...

Supercoiling not only brings DNA to life (and makes it dance) but also changes how key proteins such as #CRISPR interact with it. Thanks @qmsmith.bsky.social for the brilliant collaboration, Sylvia for developing an amazing new #imageanalysis pipeline & @eddierollins.bsky.social for beautiful #AFM.

The next #CryoEM Current Practices Webinar speaker will be by Rashmi Panigrahi from Memorial University of Newfoundland, St. John’s, Canada speaking on "Capturing Chromatin Dynamics During the DNA Damage Response" 3/26/2026 at 12 PM ET / 9AM PT.

Register today: us02web.zoom.us/webinar/regi...

Adenosine 5'-triphosphate (ATP) forms protein-free and responsive condensates in crowded environments www.biorxiv.org/content/10.64898/2026.03...