We’re happy to share our updated manuscript on Ninj1, incorporating measurements of membrane tension, cellular assays of ninj1 and ninj2 dimer stability and MD simulations of ninj1 oligmers opening and forming (see below!). @biorxivpreprint.bsky.social

www.biorxiv.org/content/10.1...

Notre système immunitaire «presse» les bactéries pour mieux les repérer L'équipe du Pr Petr Broz, au Département d'immunobiologie de l’Unil, a identifié un mécanisme jusqu'alors inconnu par lequel le système immunitaire détecte l'endotoxine, un composant clé des membranes...

🦠🔬 L'équipe du Pr Petr Broz @brozlab.bsky.social @dib-unil.bsky.social @fbm-unil.bsky.social @unil.bsky.social a identifié un mécanisme jusqu'alors inconnu par lequel le système immunitaire détecte l'endotoxine, un composant clé des membranes bactériennes.
➡️ www.unil.ch/news/fr/1769...

Vitamins: a tool to exploit against cancer A research group at Unil has identified a new mechanism that exposes the vulnerability of tumor cells when they are deprived of vitamin B7.

🥜🦀 A research group @jourdainlab.bsky.social @dib-unil.bsky.social @fbm-unil.bsky.social @unil.bsky.social has identified a new mechanism that exposes the vulnerability of #tumor #cells when they are deprived of #vitamin B7, also known as #biotin.

Press release here 👉 www.unil.ch/news/en/1770...

New article in Molecular Cell by @miriamlisci.bsky.social and @jourdainlab.bsky.social!

Groups of:
Petr Broz@brozlab.bsky.social
Peter Draber
Julia Esser-von Bieren
Ella Hartenian@ehartenian.bsky.social
Alexis Jourdain@jourdainlab.bsky.social
Sanjiv Luther
Fabio Martinon@martinon.bsky.social
Andreas Mayer
Manuele Rebsamen@rebsamenlab.bsky.social
Pascal Schneider
Margot ThomeMiazza

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social
www.sciencedirect.com/science/arti...

Join us for the upcoming innate immunity keystone. There’s a great lineup of speakers.
@keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March!
keysym.us/KSInnateImmune26 #KSInnateImmune26

Attribution des Transition Grants 2025: lauréates FBM Le Décanat de la Faculté de biologie et de médecine (FBM) de l'Unil adresse toutes ses félicitations aux cinq lauréates des Transition Grants.

Congratulations to Sina Bohnacker for her new grant. Exciting science ahead!

www.unil.ch/news/en/1767...

10 days left to apply! 👇

One month left to apply to the open postdoc position in our lab! 👇

Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.

🚨 Join our lab - we are recruiting a PhD student!

Application deadline: 20.12.2025
Starting date: from 1.04.2026

More info and application👇

Please share

@dib-unil.bsky.social @fbm-unil.bsky.social

#immunosky

Mémoire innée et inflammation chronique, une pelote de questions Les agents de l’immunité innée, soldats de première ligne du système immunitaire, « apprennent » aussi : des scientifiques de l’Unil et du CHUV étudient les impacts de cette « mémoire innée » sur cert...

🎬 When #biology met #medicine...

First episod 👉 Avec l'immunobiologiste Julia Esser-von Bieren et le médecin Antoine Reinhard

Lire l'interview croisée www.unil.ch/news/fr/1764...

@dib-unil.bsky.social @unil.bsky.social #chuv #fbm

Open PhD position in the Rebsamen lab @rebsamenlab.bsky.social !

Join us!
Still few days to apply to the open PhD position in our lab @dib-unil.bsky.social Lausanne🇨🇭!
Deadline: 20.12.2025
More info👇 and www.rebsamenlab.org

Trois récipiendaires Ambizione rejoignent la FBM Cette année, trois jeunes scientifiques viennent renforcer la Faculté de biologie et de médecine (FBM) de l’Unil. Lauréat·es des subsides Ambizione du Fonds national suisse, Ella Hartenian, David Robe...

Congratulations and welcome to Ella Hartenian @ehartenian.bsky.social, who will be launching her group in our Department of Immunobiology in 2026!

www.unil.ch/news/fr/1764...

Thrilled and incredibly honored to be selected as an @embo.org Young Investigator! Still can’t quite believe it 🎉 Huge thanks to EMBO and to all the amazing mentors, colleagues, and collaborators who made this possible!

@fbm-unil.bsky.social
@unil.bsky.social
@snsf.ch

Alexis Jourdain nommé EMBO Young Investigator Professeur assistant à la FBM, Alexis Jourdain a été sélectionné pour l’EMBO Young Investigator Programme. Cette distinction offre au spécialiste du métabolisme un soutien important pour consolider le...

👏 Bravo à Alexis Jourdain qui rejoindra l’EMBO Young Investigator Programme @embo.org au 1er janvier 2026. L’initiative européenne soutient des scientifiques en début de carrière dirigeant leur propre équipe de recherche.
🔗 www.unil.ch/news/fr/1764...

@jourdainlab.bsky.social @dib-unil.bsky.social

Congratulations @jourdainlab.bsky.social 👏

@dib-unil.bsky.social @unil.bsky.social @embo.org

Postdoc opportunity in @jourdainlab.bsky.social lab !

Ce gène qui sauve les chimiothérapies Des scientifiques du Département d’immunobiologie de l’Unil mettent en évidence un nouveau mécanisme susceptible de faire dérailler certains traitements du cancer.

🔦 Flash #Recherche

🧬🦀 Des scientifiques @dib-unil.bsky.social @unil.bsky.social identifient un nouveau #mécanisme susceptible de faire dérailler certains #traitements du #cancer. En jeu ? La perte du gène 𝘕𝘜𝘋𝘛5.
🔗 www.unil.ch/news/fr/1762...

@jourdainlab.bsky.social

New publication from Abigail Strefeler-Alexandre and @jourdainlab.bsky.social in Nature Metabolism!

The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.

Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!

@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social

New manuscript by Marcell Harhai and the Jourdain lab!

@marcellharhai.bsky.social
@jourdainlab.bsky.social
@fbm-unil.bsky.social
@unil.bsky.social

The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award!

More info: www.unil.ch/news/1749042...

Congratulations to Alexandra Boegli for her very successful PhD defense 🎓

Big congratulations to Cyrielle Hou (@dib-unil.bsky.social @fbm-unil.bsky.social) for receiving the Young Investigator Award at the 13th Meeting of the International Society of Systemic Autoinflammatory Diseases (ISSAID) in Paris! 🏆👏

And kudos to the organizers for a fantastic conference!

Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...

Excited to share our latest paper out today in @naturecomms.bsky.social !

Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.

#ImmunoSky #InterferoSky