Nutrient Signalling and Metabolism Lab wishes you and family a wonderful Christmas and a healthy, joyful and productive New Year. Kudos to lab members on their accomplishments and contributions. Season’s Greetings from Pulinilkunnil @tpulinil and Kienesberger @PKienesberger labs.

It was a productive week filled with outstanding science and networking during my visit to Hamilton McMaster's Centre for Metabolism, Obesity & Diabetes Research and Toronto for the 2025 Diabetes Canada Conference #DC2025 and I witnessed stellar science while learning from trainees and peers!

Congrats to Gurpreet Kaur, on a successful MSc. defence. Incredibly proud of Gurpreet for a thesis well done, examining the role of #TFE3 in #cardiomyocyte #metabolism and function. Thanks to the examining and supervisory research committee for their feedback @dalhousieu.bsky.social

Thrilled to have attended #SHVM2025. Outstanding science showcased by the #metabolism community. Excellent time connecting with family and friends. Grateful for #Bordeaux Hospitality and looking forward to #SHVM2026 in Osaka Japan @Soc_HrtVasMetab @DalMedNB

Lymphatic #endothelial #BCAA catabolic defects inhibit vascular endothelial growth factor receptor 3 (#VEGFR3) to undermine cardiac lymphatic integrity. Cardiac lymphatic disruption driven by impaired #BCAA catabolism drives HFpEF.
@americanheart.bsky.social
ahajournals.org/doi/10.1161/...

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes - Nature Genetics Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

#Genome-wide association study meta-analysis provides insights into the etiology of #heartfailure and its subtypes. Nat Genet (2025). doi.org/10.1038/s415...
@natureportfolio.nature.com
www.nature.com/articles/s41...

Excellent meeting of #IHCVS2025 at @UHCancerCenter. Thrilled to network with colleagues in #cardiovascular sciences. A treat to outstanding science, wonderful company, beautiful @gohawaii weather with friends and family @PKienesberger
abp.jabsom.hawaii.edu/ihcvs/

Our lab is thrilled to receive @CIHR_IRSC project grant funding to study the #cardiometabolic and #signaling role of #TFEB protein. Excited to see how understanding of TFEB control of cardiac metabolism evolves.Thank you, reviewers, team, and collaborators. We are hiring; please DM if interested.

Nutrient Signalling and Metabolism Lab wishes you and your family a wonderful Christmas and a healthy, joyful and productive New Year. Season’s Greetings from Pulinilkunnil and Kienesberger labs @tpulinil.bsky.social @pkienesberger.bsky.social .

Human HDAC6 senses valine abundancy to regulate DNA damage Nature - The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

A fascinating evolution of the functional role of BCAA in cancer. Interesting study showing human HDAC6 as a valine sensor to regulate DNA integrity. Nuclear-localized HDAC6 binds and deacetylates TET2 to induce DNA demethylation and damage
@natureportfolio.bsky.social
Nature (2024). rdcu.be/d1waX

Had a great time at the 2024 @DiabetesCanada meeting in #Halifax, networking and learning from colleagues and witnessing stellar posters and talks from trainees @pkienesberger.bsky.social @DalMedNB @DalMedSchool @impartteam

mTORC1 activity licenses its own release from the lysosomal surface The activation of mTORC1 is intricately linked to its subcellular localization, with the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues. Acharya and Demetriades uncover...

mTORC1 activity licenses its own release from the lysosomal surface
www.cell.com/molecular-ce...

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...

Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes
www.nature.com/articles/s41...

Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission The brain uses pyruvate as an energy source, and mitochondrial pyruvate metabolism in nerve terminals controls neurotransmission.

Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

www.science.org/doi/10.1126/...

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...

Published a few weeks ago in Cancer Research, we show benefit of targeting HMCR with pitavastatin in combo with AKT inhibitors in TNBC. Many amazing people contributed, led by the magnificently talented @alissandra-hillis.bsky.social! Looking to initiate new clinical trials based on this combo. 🧪

we are excited to join the community by sharing latest story from the lab where we show that mitochondrial pyruvate uptake is a critical step ATP production in hippocampal terminals and regulated by lysine acetylation of MPC. www.science.org/doi/full/10....

Oncogenic fatty acid oxidation senses #circadian disruption in sleep-deficiency-enhanced tumorigenesis
www.cell.com/cell-metabol...

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans

In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity.

1/7 🧵👇

Probing the mechanical properties of microtubules and actin from inside the cell using magnets 🧲 doi.org/10.1083/jcb.... in @jcellbiol.bsky.social

The muscle of a heart photographed through an electron microscope. Pseudo-color shows the myosin II filaments that sit at the core of the #sarcomere (cyan), the borders of the sarcomere (purple), and #Mitochondria (pink)
#science #biology #cellbiology #microscopy #photography #cardiosky #medsky

My first post on @bsky.app to connect with the scientific community. A glutamine metabolic switch supports erythropoiesis. Enhancing Glutamine Synthetese activity alleviates the pathological defects in β-thalassemia.
DOI: 10.1126/science.adh9215
www-science-org.ezproxy.library.dal.ca/doi/10.1126/...

Hi Sarah could you add me to this community? Best wishes

Could you please add me to this group? Thank you.

Could you please add me to this group? Thanks for the wonderful initiative.

Could you please add me to this research community? Thank you for the initiative.

Thank you for the initiative. I hope to be part of and continue learning from this community.