ピクノジェノールⓇが血管機能を向上させるメカニズムを解明 小林製薬が発表した研究により、ピクノジェノールⓇのオートファジー活性亢進作用が血管機能を強化するメカニズムが明らかになりました。詳細をお伝えします。

ピクノジェノールⓇが血管機能を向上させるメカニズムを解明 #大阪府 #大阪市 #オートファジー #ピクノジェノール #TFEB

小林製薬が発表した研究により、ピクノジェノールⓇのオートファジー活性亢進作用が血管機能を強化するメカニズムが明らかになりました。詳細をお伝えします。

Obestatin treatment links mitochondrial homeostasis and skeletal muscle repair in Duchenne muscle dystrophy - Molecular Biomedicine Duchenne muscular dystrophy (DMD) is a genetic, progressive neuromuscular disease caused by mutations in the dystrophin protein which compromise the integrity of the sarcolemma. Current care of DMD in...

#Research
#Obestatin treatment links mitochondrial homeostasis and skeletal muscle repair in Duchenne muscle dystrophy doi.org/10.1186/s435...

#DuchenneMuscularDystrophy #Mitochondria #Utrophin #TFEB #NFATc1

Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity | Journal of Cell Biology | Rockefeller University Press Posttranslational modifications play a crucial role in regulating autophagy and lysosome–related transcription factor TFEB. Huang et al. find the increase

New PTM (lactylation) linked with #TFEB stability and increased autophagy and lysosomal activity @jcb.org

Frontiers | Assessing the efficacy of the natural disaccharide trehalose in ameliorating diet-induced obesity and metabolic dysfunction Trehalose is a naturally occurring disaccharide with versatile commercial applications and health benefits, including promise as a therapeutic for obesity an...

Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help.

www.frontiersin.org/journals/nut...

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L axis controllin...

Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey.
www.cell.com/immunity/abs...

Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK

Hello everyone!

We are finally here on #BlueSky and excited to connect with the growing scientific community here! We are based in Copenhagen at the NNF-CBMR, University of Copenhagen @ucph.bsky.social and are a #MetabolicSignaling laboratory interested in everything #AMPK #TFEB #SIK #Glycogen

Our lab is thrilled to receive @CIHR_IRSC project grant funding to study the #cardiometabolic and #signaling role of #TFEB protein. Excited to see how understanding of TFEB control of cardiac metabolism evolves.Thank you, reviewers, team, and collaborators. We are hiring; please DM if interested.