Another #cilia kinesin motor: kinesin-8 KIF19A localizes to ciliary tips of Drosophila mechanosensory neurons

In 2012, Hirokawa lab showed KIF19A regulated ciliary length & localized to ciliary tips in mice; knockouts had hydrocephalus and female infertility phenotypes (PMID 23168168). #ciliopathy

Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/...

#Cilia

Deciphering mechanical determinants of morphological evolution A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these modules reprograms morphology, revealing how variation in tissue-scale mechanics underlies morphological diversity.

Now online! Deciphering mechanical determinants of morphological evolution

Endoplasmic reticulum patterns insect cuticle nanostructure Original paper: [LINK] Video Summary by Sachi Inagaki (RIKEN Center for Biosystems Dynamics Research, Kobe, Japan) Description: In this work, Inagaki and coworkers report the intracellular mechanism…

🎦 See a short video summary by Sachi Inagaki: youtu.be/50JRPysrTNU

How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...

Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...

#CryoET

Are we living in a parallel universe? The strange physics of Stranger Things Nature - Nature speaks to theoretical physicists to explore the real theories that inspired the hit series. Warning: contains spoilers.

Demogorgons, Shadow Monsters and psychokinetically gifted 12-year-olds are strictly fictional creations - but what about the parallel universe at the core of Stranger Things?

go.nature.com/48Mo2br

Membrane morphologies arising from multiconformational protein states Dynamic compartmentalization by lipid membranes is a hallmark of living cells. The shapes of membrane surfaces are tightly coupled to their various functions, resulting in the myriad of complex membra...

www.cell.com/biophysj/abs...

Structure and assembly of the A-C linker connecting microtubule triplets in centrioles Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...

What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social

rupress.org/jcb/article-...

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

A switch to non-proliferative growth sustains Drosophila wing development during the early pupal stage Using precise tissue volume quantification, El Marzkioui, Gaugué, et al. show that wing primordia continue to grow during the early pupal stage, a phase of increased cell volume driven by insulin/IGF ...

Our new paper is out in @currentbiology.bsky.social! Using 3D reconstructions and volume measurements in Drosophila wing primordia, we show that growth can be uncoupled from cell proliferation and uncover a new time window for growth arrest.
With @leopoldlab.bsky.social
www.cell.com/current-biol...

This creature can 3D-print its own body parts Bristle worms have protrusions that act like a 3D printer, helping us to understand how cells regenerate.

Out stody Is now on National Geographic!!!

www.nationalgeographic.com/animals/arti...

Very proud to share our latest preprint: postdoc/LRSF fellow Yue Rui studies the mechanisms regulating attachment of the cell wall to the plasma membrane. The Cellulose Synthase Complex and REMORINs determine the extent of attachment and root osmotic stress tolerance. www.biorxiv.org/content/10.1...

An amoeba with teeth. When building its shell, Netzelia corona selects sharp grains of quartz and positions them around its aperture with the tips pointing inward. I took a few closeups, yesterday. #ProtistsonSky #amoebae #peatlands #MEvoSky

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
elifesciences.org/articles/931...

Belyantseva and Liu et al. report that taperin encircles and stabilizes F-#actin at auditory hair cell #stereocilia bases and bundles F-actin. Taperin deficiency causes stereocilia disassembly, rootlet breakage at pivots, and other abnormalities culminating in deafness. rupress.org/jcb/article/...

I can say that I lived in the times of CRISPR. - @jenniferdoudna.bsky.social 's talk at @gmivienna.bsky.social 25th year anniversary jubilee at ÖAW.

Work for us Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...

#DevBio job opportunity!

Development (@dev-journal.bsky.social) is looking for a new Community Manager to run our community site, the Node (@the-node.bsky.social) – a great opportunity if you love devbio, #stemcells, #scicom and community engagement. Happy to chat informally about the role.

⬇️

I’ve just updated the BioEmu notebook to include the powerful LogMD. Now, you can generate equilibrium ensembles and explore the full ensemble directly in the notebook.

A huge thanks to Alexander Mathiasen for the support! 🙌

🔗 Try it on Google Colab: lnkd.in/gcuqd-fT

Kyojiro Ikeda @beingkyo.bsky.social @univie.ac.at presenting now at #DevStem2025 @viennabiocenter.bsky.social on first mechanistic & molecular regulators of #bristle biogenesis in the #Platynereis model. Also check Kyojiro's recent @naturecomms.bsky.social publication www.nature.com/articles/s41...

Are you in for a PhD project on neural #regeneration? Only 2 more weeks to apply to the @vbcscitraining.bsky.social @univie.ac.at VBC PhD programme: vbcphd.at ! Pls. see tiny.cc/RaibleLab and our recent @naturecomms.bsky.social study www.nature.com/articles/s41... for information and contact!

Open positions Open positions

Take the next step in your academic career and become part of a thriving international research community!
The Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (VDS-PhaNuSpo) are offering 13 fully four-year funded PhD positions at the moment!

Incredible 4Pi and pan-expansion imaging of the Golgi 👇

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.

Nature research paper: Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium

https://go.nature.com/4hrHX0v

My continued biological education
#Mechanobiology #RigiditySensing

Stiffness Sensing by Cells

"Substrate Stiffness Can Lead to Heritable Epigenetic Changes"

"Cell Motility Is Faster on Soft Elastic Substrates"

#PhysiolRev 2020
journals.physiology.org/doi/full/10....

Cool story on nanopatters! We had picked Osiris genes as erect wing regulated, but no clue what this was about.
genomebiology.biomedcentral.com/articles/10....

Can you spot the difference? 🔬
SiR-actin labeling can be cytotoxic and affects actin dynamics - while the new XActin probes do not! Developed by @veselin-nasufovic.bsky.social and perfect for time-resolved and STED imaging without the need for genetic manipulation.
www.biorxiv.org/content/10.1...