Frogs help Fred Hutch find the shape of small things Frogs have made significant contributions to Fred Hutch science over the years as a model organism that shares much of our biology, but they've been absent from the menagerie for about two decades. Dr...

Dr. @yarimura.bsky.social brings frogs back to Fred Hutch after a long absence to study the structure of DNA-linked molecular complexes that change during the cell cycle and malfunction in cancer and other diseases. bit.ly/3J8S5Ae

Selected frames of a live-cell imaging time-course experiment. A single cell is shown, co-expressing PEEL-1::eGFP and PMPL-1::mCherry. The nucleus is labeled (“N”). t = 0 is 16 hrs after transfection. Acute swelling can be seen (t = 2 hr 30 min), followed by a transient blob or protrusion (arrow) jetted out by the cell (t = 4 hr 15 min) and later reabsorbed (dotted arrow) (t = 4 hr 20 min). Scale bar = 10 µm.

#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:

A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.

Huge congratulations @jbloomlab.bsky.social!

In the midst of the dark ages, we MUST retain optimism—keep going, keep publishing, keep talking science, and keep doing fun experiments! Our latest paper on the fascinating TF SKN-1/NRF presents exciting new findings using our one and only #Celegans #genetics #oxidativestress #proteasome

Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2 The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregu...

Our latest work on the ever-fascinating skn-1 transcription factor (Nrf1 and Nrf2 for non-worm people).

www.biorxiv.org/content/10.1...

Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.

Check out a fantastic @elife.bsky.social article highlighting @yarimura.bsky.social’s MagIC #cryoEM technique - a method using specialized magnetic beads that makes it possible to study the structure of proteins from dilute samples. elifesciences.org/articles/105...

Friday Afternoon Seminars (FAS), this Friday 11/22 at 4pm in Pelton. Elyse Christensen, Lehrbach Lab A cabal of conserved ubiquitin ligases cooperate to ensure robust protein turnover Liberalis Boila, Kugel Lab Epigenetic dysregulation in IDH mutant intrahepatic cholangiocarcinoma

The best part of the week kicks off soon: Friday Afternoon Seminars!

Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!