Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6...
@idrm.ox.ac.uk @oxforddpag.bsky.social

Excited to share our commentary: kidney-international.org/article/S008... in @kidneyint.bsky.social on a groundbreaking study by Li et al. in @science.org. Their study uncovered how hypoxia-responsive tRNA-derived small RNAs drive renal protection via regulating #RNAAutophagy. #tDRs #KidneyFibrosis

Excited to present our work at @asnkidney.bsky.social
#KidneyWk in Texas next week! I'll be presenting our poster on Thursday, & AkchurinLab will also present. If you're interested in learning more about the functions of #macrophages during #kidney-lung interorgan interaction, please stop by #CKD

Thank you to @atscommunity.bsky.social & @ats-aii.bsky.social for the opportunity to share our work on kidney-lung communication. It was a pleasure to present & engage in insightful discussions! If you’d like to learn more about our work, here is a link to the talk: youtu.be/wqbt4F6Ohrk?...

ICYMI: Our new collection highlights recent advances in our understanding of #macrophages and #dendriticcells, and their roles in #infection, #allergy, #cancer, #neuroinflammation, and #neurodegeneration. Explore new research 👉 rupress.org/jem/collecti...

This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age.

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.

Learn more: scim.ag/3IYhnk7

Review: Immune system influence on physiology
www.science.org/doi/10.1126/...

Advances in Preventing Transmission of Mitochondrial DNA Diseases | NEJM The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle,...

Advances in Preventing Transmission of Mitochondrial DNA Diseases | New England Journal of Medicine
www.nejm.org/doi/full/10....

Dysfunctional mitochondria trap proteins in the intermembrane space | The EMBO Journal imageimagePoorly energized mitochondria trap a subpopulation of mitochondrial precursor proteins in the intermembrane space. This article introduces ‘mitochondrial triage of precursor proteins’ (MitoT...

Dysfunctional mitochondria trap proteins in the intermembrane space | The EMBO Journal www.embopress.org/doi/full/10....

WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

Nature research paper: WSTF nuclear autophagy regulates chronic but not acute inflammation

https://go.nature.com/45XMoOB

#Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases. New review from Natalia Reglero Real @cbm-csic-uam.bsky.social‬, Loïc Rolas and Sussan Nourshargh: rupress.org/jem/article/...

#InnateImmunity #inflammation

SIC Abstract Awardee Dr. Divya Bhatia is presenting today in session B15 9:15-11:15am. #ATS2025
@ats-assemblies.bsky.social
@atscommunity.bsky.social
@ats-aii.bsky.social

Cells are swapping their mitochondria. What does this mean for our health? Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Those cheeky little mitochondria 🤣

Not only are they ancient bacteria living symbiotically in all our cells (weird!)

and are inherited maternally (yay feminism!)

but they also move from cell to cell, improving cell performance against stressors. 🤯

www.nature.com/articles/d41...

Congratulations to the 2025 abstract scholarship awardees!

#ATS2025 #AII

SIC awards! 👏👏👏

Huge congratulations to the Rising Star Awardees and SIC Abstract Awardees!

@divyabhatia.bsky.social
@sophieecollins.bsky.social
@lurod8.bsky.social
@meretelong.bsky.social
@wonnie1981.bsky.social
Jehan Alladina
Thomas File
Taylor Coston

Per source, NIH has been instructed to hold off from issuing ALL awards to Harvard, Cornell, Columbia, Brown, and Northwestern (including med schools)

Agency staff have also been instructed to not speak about this funding freeze to grantees and applicants

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

Check out the paper below with its related Perspective in @science.org
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...

Shared and distinct responses of human and murine alveolar macrophages and monocyte-derived macrophages to Mycobacterium tuberculosis www.biorxiv.org/content/10.1101/2025.02....

Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.

#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections

I’m honored & truly grateful to receive the 2025 Science & Innovation Abstract Award @ats-sic.bsky.social for @ats-aii.bsky.social & an Abstract Scholarship. This recognition means a lot. Eager to share our work & gain new insights from @atscommunity.bsky.social #ATS2025 @atsearlycareer.bsky.social