Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential - npj Biomedical Innovations npj Biomedical Innovations - Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

I’m pleased to share our lab’s first paper (a review), highlighting new insights into macrophages, their mechanobiology, and cancer therapeutic potential through both genetic and non-genetic approaches. @jacobsschool.bsky.social.

www.nature.com/articles/s44...

Epigenetics Update - Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs go.nature.com/4cLhyvG

Blanche Capel, Marc A. Marti-Renom, and Darío G. Lupiáñez in NSMB

#Epigenetics #Chromatin
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Empower your research with high-res epigenetic insights at epigenometech.com

Demystifying Oral Epithelial Dysplasia: a histological guide

Enhanced interpretation of WHO 28 features

Normal oral mucosa variants

Core architectural & cytologic abnormalities

#Pathology 2024
www.pathologyjournal.rcpa.edu.au/article/S003...

#CytoQuiz #SoftTissue 🔬
A) Leiomyosarcoma (LMS)
B) Leiomyoma
C) Gastrointestinal stromal tumor (GIST)
D) Schwannoma
#CytoPath #Pathology
🙏 🖼️ @CytoAtlas

What is known? - PCS and ME/CFS are associated with persistent endothelial dysfunction and increased long-term cardiovascular risk. - Neurocognitive symptoms in post-viral syndromes have been linked to impaired neurovascular coupling. - Retinal vessel analysis provides a validated, non-invasive readout of systemic and cerebral microvascular health. What new information does this article contribute? - PCS is characterized by persistent functional and structural retinal microvascular dysfunction - Retinal endothelial dysfunction scales continuously with post-viral disease severity and is most pronounced in patients fulfilling ME/CFS criteria. - Retinal microvascular alterations are linked to inflammatory–endothelial activation and iron dysregulation, identifying a biologically coherent vascular phenotype.

New from Germany:

Microvascular Remodeling and Endothelial Dysfunction Across Post-COVID-19 and ME/CFS: Insights from the All Eyes on PCS Study

www.medrxiv.org/content/10.6...

#MEcfs #LongCovid #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome

Pathology as Primary Care Why the

Yes, we do rock actually #PathSky #MedSky

www.thepathologist.com/issues/2025/...

The baby whose life was saved by the first personalized CRISPR therapy KJ Muldoon is part of Nature’s 10, a list of people who shaped science in 2025.

KJ Muldoon’s name and photo were splashed across newspapers and broadcasts around the world as the first known person to receive a personalized CRISPR-based genome-editing therapy. He’s part of Nature’s 10. 🧪

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Psilocybin holds promise as a treatment for mental illnesses. One dose of psilocybin induces structural remodeling of dendritic spines in the medial f…

Study maps how psilocybin reshapes brain circuits linked to depression

"Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks"

www.sciencedirect.com/science/arti...

CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review

🎯Schematic Diagram of a CAR and Different Types of T-Cell Therapies for Cancer

jamanetwork.com/journals/jam...

Inducing immunity against cancer via the gut Could a microbe that can smuggle antigens into the immune system of the gut provide a simple way to treat cancers?

Yet another unique way to stimulate cellular immunity against cancer.

“Using the gut immune system to induce cellular immunity is a unique approach,” Shirakawa notes. “And it should be very easy to extend it to other antigen proteins and also infectious diseases.”
#ScienceSunday

Review Article Noninvasive Assessment of Liver Fibrosis Laurent Castera, M.D., Ph.D., Mary E. Rinella, M.D., and Emmanuel A. Tsochatzis, M.D., Ph.D. A figure showing the diagnosis, staging, and progression of liver fibrosis. The NEJM identity sits at the bottom.

The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests, which the authors review. Learn more: nej.md/4hwZMgj

#MedSky #GastroSky

Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit bey...

The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect
thelancet.com/journals/lan...

Quantitative Genetics in Natural Populations Phenotypes evolve under natural selection if, and only if, they are genetically variable. While evolutionary ecologists have long studied natural sele…

Myself and Alastair Wilson wrote an updated version of our 2016 primer to quantitative genetics in the wild: www.sciencedirect.com/science/arti.... Happy to share a copy if interested. It is also on research gate

UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.

This is huge news!
UBC has developed an enzyme that can convert donor organs to type O, making them universal.
Normally a using organs of the wrong blood type causes the recipient's immune system to attack the organ, leading to failure.
❤️🇨🇦⚕️
news.ubc.ca/2025/10/univ...

A Chemistry Nobel for the invention of MOFs! Here’s a great article on what these materials are and why they’re now being used to eg harvest water and suck up carbon dioxide. Congrats to Kitagawa, Robson and Yaghi! #ChemNobel
By @kms163.bsky.social | @nature.com
www.nature.com/articles/d41...

For centuries, anatomists debated true origin of levator veli palatini—vital for speech & swallowing. Researchers found it arises from cartilaginous Eustachian tube not petrous bone, reshaping understanding of vocal tract evolution
Pagano et al: anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...

What if pediatric T-cell leukemia isn’t just one disease, but many?

New study reveals 15 genomic subtypes of pediatric T-ALL, transforming risk assessment and treatment! Read more: ashpublications.org/...

Clinical metagenomics for diagnosis and surveillance of viral pathogens Nature Reviews Microbiology, Published online: 13 August 2025; doi:10.1038/s41579-025-01223-5Metagenomics approaches are being increasingly used for the diagnosis of viral infections, outbreak investigation, and new and emerging pathogen surveillance. This Review highlights sequencing approaches and technologies, discusses their applications in diagnostics, surveillance and virus discovery, and outlines future perspectives for the field.

New online! Clinical metagenomics for diagnosis and surveillance of viral pathogens

This tiny device can shrink dangerous blood clots. It’s called the ‘milli-spinner’ and its invention was partly an accident…

From period pain to heart disease, the gender health gap is real – here’s how to close it Millions of women live with delayed diagnoses, dismissed pain and inadequate care. Now, progress is at risk of reversal.

Millions of women live with delayed diagnoses, dismissed pain and inadequate care. Now, progress is at risk of reversal.

On this day in 1863, Harriet Tubman's forces freed more than 700 slaves in a raid of South Carolina plantations .

mississippitoday.org/2025/06/02/o...

Bacteria-killing paint could dramatically improve hospital hygiene – Physics World A novel antimicrobial coating can be applied to a range of surfaces to destroy bacteria and viruses

An antimicrobial coating can be painted onto a range of surfaces to continuously destroy bacteria and viruses. 🧪⚛️ physicsworld.com/a/bacteria-k...

bsky.app/profile/hrw....

It is so normalized that I hear it regularly among average to highly informed and scientifically minded people.

In most cases it's something akin to: "seems the most likely" and "well, that one turned out to be true".

It's mind boggling 🤯

"die Not im Gazastreifen" - Ja, so kann man einen Völkermord natürlich auch nennen.

Ich frage mich ja, wer für diesen wohl verantwortlich ist und welche Mittäter dies unterstützen?

Within the last hour - the Senate hearing is ongoing.

AE1/AE3

#PathSky Right femur lesion in an older woman. Diffusely keratin-positive with 3 different antibodies.

The biopsy from this adult kidney transplant recipient shows features of cytomegalovirus (CMV) infection, including prominent enlargement (“cytomegalo-”) of tubular epithelial cells and their nuclei, along with small basophilic inclusions which expand the cell cytoplasm.

#renalpath #kidneypath

"It’s like I’m surrounded by an electric fence that will trigger a bad day if I touch it. But the fence is invisible, and moves every day."

Excellent article about the stigmatization of ME/CFS and its deep roots in misogyny female-biased diseases regularly encounter.

#LongCovid #ME/CFS

Sir David Attenborough laying in the sand next to a turtle.

Sir David Attenborough laying on the ground next to a group of puffins.

Sir David Attenborough laying on the ground next to a group of meerkats

Sir David Attenborough laying on the ground next to two gorillas.

Happy 99th Birthday to Sir David Attenborough!

Joyfully showing the beauty of the planet we live on and share with others. Always educating on the complex ecological interactions it relies on.

A legend - here seen in his natural habitat: on the ground next to one of world's beautiful creatures 🌍