π One CRISPR approach to treat them all? Well, kind of!
βΌοΈ In our latest CRISPR180", we tell you everything about PERT, the newest CRISPR approach which could allow scientists to treat hundreds of different genetic diseases simultaneously.
π― CRISPR-based gene knock-in enables scientists to insert new coding sequences into the DNA. But how do we drive and control expression levels?
π‘ In this handy dandy infographic, we compare knock-in approaches using endogenous and exogenous promoters, summarizing the pros, cons, and uses of each.
π¨PSA: CRISPR is not just a molecular scissor. βοΈ
Itβs more like Eevee π₯β a flexible little powerhouse that can evolve into all sorts of molecular creatures when paired with the right βstoneβ (aka a clever protein fusion).
Check out our CRISPR Eeveelution lineup.
Do you know the difference between autologous and allogeneic CAR-T cells? CRISPR can be used to make allogeneic, off-the-shelf CAR-Ts that can help cancer patients worldwide receive quick and effective treatment. A life-saver! #car-t #cart #crispr #molecularmedicine #cancertreatments
@sniprbiome.bsky.social has officially dosed the first human patient in a clinical trial using CRISPR-armed bacteriophages to kill off antibiotic-resistant E. coli bacteria in patients with blood cancer. Read their full press release here: lnkd.in/ehwSKyB9
π₯ A long time ago in a petri dish far, far awayβ¦
Bacteria developed CRISPR to fight against phages. But now scientists have flipped the script harder than Anakin at a Jedi council meeting.
Phages are back! And this time they're the ones wielding CRISPR to kill off antibiotic-resistant bacteria.
π§¬π₯ CRISPRβs Evolution Continuesβ¦ π₯π§¬
Over the years, the CRISPR PokΓ©dex has kept expanding with new technological evolutions and crazy new Cas variants with different tricks.
π At WeDoCRISPR, we scour every corner of the CRISPR world to find that elusive shiny Gyarados and tell you all about it!
Weβre sure you saw the big news last week β personalized CRISPR just saved a babyβs life.
But how did the scientists do it?
In our latest CRISPR180", Antonio Carusillo and Manel Llado break down this amazing research for you in just 3 minutes.
#CRISPR #BaseEditing #RareDisease #GeneEditing
Did you know that CRISPR can regulate gene expression?
CRISPR can be used to regulate gene expression, either activating or repressing the activity of target genes to study their functions. But how does CRISPR achieve that?
All the info you need is here.
#crispr #geneediting #biotech #science
Want to learn how to design sgRNAs that are efficient and specific, and how to clone them like a pro? More importantly, wanna avoid all the silly design and cloning mistakes that cost you time and money? Then check out our latest "How to CRISPR 101"!
www.linkedin.com/feed/update/...
Did you know that scientists can use genetic barcodes to improve the sensitivity and accuracy of CRISPR screenings?
In the handy infographic below, you can learn how genetic barcodes (iBARs) added to your sgRNAs can make your CRISPR screenings more sensitive and accurate.
π§π΅π² ππ΄π² πΌπ³ ππ-π±π²ππΆπ΄π»π²π± ππ₯ππ¦π£π₯ πΆπ π΅π²πΏπ²
Scientists at Harvard University developed a machine learning-based tool that can design the perfect Cas9 enzyme to target any possible PAM sequence with high efficiency and specificity. Check out our video to learn how it works!
Use the tool: lnkd.in/desswhHr
Check out our latest installment of "How to CRISPR 101", where we give you a step-by-step explanation on how to do your first CRISPR knock-out screening to individually interrogate the functions of thousands of genes in cell survival and drug resistance.
Did you know that CRISPR's fascinating story started in a small lab in Spain in 1993? Francisco Mojica discovered CRISPR while studying a bacteria commonly used to produce mozzarella and yogurt.
If you want to learn more about CRISPR's fast journey from bench to bedside, check out this Timeline!
At #CRISPRMED25, we ran the first WeDoCRISPR Flash Talk Competition, challenging scientists to explain their science to 25 local highschoolers without scientific figures, using memes, cartoons and anything they could come up with.
It was a blast! Congrats to our winner Martina Franchini!
The first day of #CRISPRMED25 was a blast!
Jimi Olaghere gave a first-hand account of having sickle cell disease and how the CRISPR treatment CASGEVY changed his life.
Then we heard the OGs of gene editing talk about how they started the field and how gene editing changed with CRISPR.
We can't wait to meet the CRISPR Medicine community in Copenhagen next week for #CRISPRMED25.
Say hi to Antonio Carusillo and Manel Llado, and don't miss the WeDoCRISPR Flash Talk Competition on Thursday evening. It's going to be a blast!
See you there!
CRISPR just got a new cousin, and it's a wild one! Check out our latest CRISP180" to learn about TIGR, a new type of Cas9-like system discovered by Feng Zhang's lab at the @broadinstitute.org
youtu.be/CCceQHy_RMc
CRISPR-based technologies are famous for their ability to edit the DNA. But did you know that we can also use CRISPR to edit the RNA? Wanna learn how RNA editing works? Check out our explainer! #CRISPR #RNAediting #geneediting #sciencecommunication #sciencemadesimple #genomeediting
If you work with CRISPR or are learning about it, we're sure you've heard the name Prime Editing many times before. But do you know how it works?
Check out our latest explainer to learn all you need to know about how Prime Editing works and what you can use it for! www.linkedin.com/feed/update/...
A new base editing treatment for Stargardt's disease! In our latest installment of CRISPR180", Antonio Carusillo, Ph.D. and Manel Llado Santaeularia, PhD. tell you everything you need to know about this new fascinating approach. Check it out!
Read the full paper here: lnkd.in/dqzQfNkY
You can find on LinkedIn our recent β CRISPR in 180β .
Here we report the latest results from a study by @unibas.ch and @beamthx where they deploy base editing in mice and NHP to treat Stargadts condition!
#crispr #genetherapy #baseediting
www.linkedin.com/posts/wedocr...
Early Bird registrations for hashtag#CRISPRMED25 are extended until January 10th! Check out the testimony of Laura Castilla Vallmanya, Ph.D., who attended last year's conference and received one of the Best Poster Awards! Register here: event.fourwaves.com/crisprmed25 youtu.be/PIqnnS9l_KA
WeDoCRISPR wants to wish everyone a happy holiday!
We will take a short break, but will be back next year with a lot more CRISPR content!
In the meantime, you can refresh your CRISPR knowledge on our website: lnkd.in/e-hASGB and YouTube channel: www.youtube.com/@WeDoCRISPR
See you soon!
CRISPR and genetic engineering is an exciting field!
What would you like us to cover next? Tell us here in the comments section!
#cellgenetherapy #crisprcas9 #cas9 #geneeditig #rarediseases #cancer
πππ πππ’ππ’π§π π’π¬ π¨π§π π¬πππ© ππ₯π¨π¬ππ« ππ¨ ππ‘π ππ₯π’π§π’π!
Researchers at HuidaGene Therapeutics recently used an RNA editor in mice and non-human primates to effectively regulate MECP2 protein levels. Check out our latest CRISPR180" video for more information about this new approach: youtu.be/iG8SnzlZyDw
Are you ever confused by the different gene editing tools out there? The gene editing toolbox has rapidly expanded in the last few years, and base editing, prime editing, and now bridgeRNA have become common words in a scientist's vocabulary.
Here is a handy reminder !
#crispr #crisprmed #cas9
#CRISPRMED brings together Accademia and Industry to deliver an event focused on the impact of genome editing on patientsβ lives and the current challenges to treat new therapeutics and how to make safer, scalable and more accessible.
#crisprcas #geneediting
crisprmedicinenews.com/crisprmed/cr...
Are you a CRISPR enthusiast and excited to know the latest from the genome editing field?
Then stick with us as every week we deliver to you up to date content from the CRSIRP field.
We are already active on LinkedIn and YouTube, so check us out and we hope to hear from you!
#crispr #genetherapy
β οΈ Gene editing may be considered a misleading term as nowadays we are far beyond "just changing the DNA"!
Here is what we can do!
Want more WeDoCRISPR content?
Follow us on LinkedIN and Check out our YouTube channel: lnkd.in/dPCqParT
#crispr #crisprcas9 #geneediting #geneandcelltherapy