🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.
Out in @nature.com
➡️ bit.ly/43SD9xj
Yesterday in Valencia Dr. @nlbigas.bsky.social received the 2025 Premio Rei Jaume I in Biomedical Research. Her work on how cancer mutations arise and evolve has earned major recognition!
Congratulations, Núria! 🙌
#ReiJaumeI #CancerResearch
@cerca.cat @icreacommunity.bsky.social @bbglab.bsky.social
Just kicked off the #BarcelonaBioMed Conference “When Development Meets #Cancer-Origins, Models & Therapies in #ChildhoodCancer”
Excited to hear from an outstanding line-up of speakers!
Organized by #IRBBarcelona & @sjdhospitalbarcelona.org
With the support of Fundación @bbvaenespana.bsky.social
🔬 #ColorectalCancer evades #immunotherapy using a dual barrier:
A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.
📰 @natgenet.nature.com
➡️ bit.ly/49BJaC0
#IRBScience @batllelab.bsky.social
🧪
A study published in #CancerDiscovery reveals why some colorectal cancers withstand pharmacological inhibition of #KRAS oncogene activity.
Read more here ➡️ https://bit.ly/3L0Cl2G
#CancerResearch #ColorectalCancer @batllelab.bsky.social
🧪
🧪 A new study co-led by Dr. Antonio Zorzano and Dr. Manuela Sánchez-Feutrie from #IRBBarcelona suggests the use of Neuritin 1 to treat obesity without reducing food intake.
The research unveils a new mechanism of action and has been published in @natcomms.nature.com
More 👉 shorturl.at/ccDb5
🧪Top Spanish hospitals adopt the MAF Test to improve breast cancer treatment. This pioneering test by #IRBBarcelona spinoff #Inbiomotion helps oncologists determine which #BreastCancer patients should be treated with bisphosphonates to improve their prognosis & survival.
➡️ https://shorturl.at/AbzSI
🔬An aggressive #ChildhoodCancer case opens new avenues for advanced cell therapies.
✍️ #IRBBarcelona, @cnag-eu.bsky.social, @sjdhospitalbarcelona.org
📰 Annals of Oncology
Read more here ➡️ bit.ly/40Ut5lC
📌 DOI: 10.1016/j.annonc.2025.05.530
#IRBScience
🧪
🔬 A new study by #IRBBarcelona reveals the limitations of current methods used to study cell communication.
📰 #GenomeBiology
✍️ @epareja10.bsky.social @ptck72.bsky.social
➡️ bit.ly/4kvcD2a
📌 DOI: 10.1186/s13059-025-03677-5
#IRBScience
🧪 🧵👇
🧬New approach to decoding mutational signatures improves prediction of prognosis in #OvarianCancer.
📰 #GenomeMedicine ✍️ Patricia Ferrer-T Iván Galván-F & @fransupek.bsky.social
➡️ bit.ly/4nA579b 📌DOI: 10.1186/s13073-025-01497-7
@genomedatalab.bsky.social @bric-ucph.bsky.social
🧪
✨ Today we had a successful first day at SONAR+D, where our Artist in Residence Toni Aranda presented the project #Cascade, an immersive #VR proposal.
🕹️ It is the final result of his residency, after spending time with IRBBarcelona researchers and learning firsthand about the their research.
⚠️ Last week to vote for Dr. Carla Garcia-Cabau and Dr. Anna Bartomeu, finalists for their work on understanding the molecular mechanisms of #autism in #VanguardiaDeLaCiencia award.
🗳️ Until June 22nd! ➡️ shorturl.at/RZBqw
@lavanguardia.com @xsalvatella1.bsky.social @bist.eu @cerca.cat
⚠️Remember that you can vote for Dr. Carla Garcia-Cabau and Dr. Anna Bartomeu, for the #VanguardiaDeLaCiencia prize.
Finalists for their work on understanding the molecular mechanisms of #autism
🗳️Until June 22nd! ➡️ shorturl.at/RZBqw
@lavanguardia.com @bist.eu @cerca.cat @xsalvatella1.bsky.social
➡️ @batllelab.bsky.social from #IRBBarcelona has been awarded an #ASPIRE grant from the @themarkfdn.bsky.social, co-funded by the @contracancerinv.bsky.social to investigate resistance to immunotherapy in colorectal cancer metastasis.
Read the news here 🔗 shorturl.at/EjGBC
@bist.eu @cerca.cat
🔝 Dr. Carla Garcia-Cabau and Dr. Anna Bartomeu, researchers from #IRBBarcelona are finalists of the prize #VanguardiaDeLaCiencia of @lavanguardia.com for their advance in understanding the molecular mechanisms of autism.
🗳️ You can support them by voting them until June 22nd!
➡️ shorturl.at/RZBqw
🧬 New tool to generate aneuploidies and analyse their impact on development.
The tool created by @milanlab.bsky.social helps better understand this phenomenon, which is the main cause of spontaneous miscarriage.
📰 Published in #CellGenomics by #IRBBarcelona
Read the news ➡️ shorturl.at/Ektif
👇
🔬 The protocol enables researchers to generate custom bioactivity spaces and signatures, allowing the exploration and annotation of new chemical compounds with biological meaning.
#DrugDiscovery #ChemicalBiology #ComputationalBiology #MachineLearning #OpenScience
@bist.eu @cerca.cat
🔬A new computational protocol to explore bioactivity spaces and signatures, out now in @natprot.nature.com!
Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker
Article ➡️ www.nature.com/articles/s41...
Un #OpenDayIRB25 per recordar! Aquest any ho hem tornat a fer... i ha estat ESPECTACULAR!😍
Hem viscut una jornada plena de ciència, emoció i descobriments a la jornada de portes obertes de l'#IRBBarcelona, gràcies per acompanyar-nos en aquest dia especial! ☺️☺️
🤗Here are some highlights from this #OpenDayIRB25 morning with families!
🔎Discoveries, experiences, and smiles from the little ones during the science workshops, the escape room, and the lab
tours.
We also danced a lot during the #RadioPAati concert by Amanda Álvaro and @thecrabapple.bsky.social 🎶
🔬‘Barcodes’ written into our DNA reveal how blood ages
Naturally occurring methylation patterns reveal changes in blood which are detectable at age 50 and almost universal by 60
📰 Published in @nature.com by #IRBBarcelona & @crg.eu
Read the news ➡️ bit.ly/4jZHQeB
⬇️ ⬇️
Dr. Fran Supek
Dr. Ahmed Khalil
🔬 #IRBBarcelona researchers @fransupek.bsky.social & Ahmed Khalil have developed DiffInvex, a new computational method that tracks the evolutionary shifts in selection pressure during tumorigenesis and chemotherapy.
Read the news ➡️ bit.ly/43tyKko
🔬 Just like species evolve to survive, tumours adapt to resist treatment.
A new computational tool reveals how cancers rewire driver genes to beat chemotherapy.
Published in @natcomms.nature.com
Read the news ➡️ bit.ly/43tyKko
#CancerResearch #Genomics #ComputationalBiology #DrugResistance
⬇️
🧪 Registrations are open for the #BarcelonaBiomed conference "When Development Meets #Cancer: Origins, Models & Therapies in #ChildhoodCancer."
Organised by Dr. Alexandra Avgustinova, Dr. Cayetano González (@irbbarcelona.org) & Dr. Jaume Mora (@sjdhospitalbarcelona.org])
➡️ f.mtr.cool/hpdbcpiant
Más de 100 expertos, coordinados desde el #IRBBarcelona, reclaman que los datos en simulación molecular se ajusten a los principios 'Fair': accesibles, interoperables, fáciles de encontrar y reutilizables.
📰 @lavanguardia.com
🔗 https://f.mtr.cool/ncjierxuzt
#IRBScience #MolecularSimulation
🧪
Over 100 experts in #MolecularSimulation, coordinated by #IRBBarcelona, have published an article in @naturemethods.bsky.social advocating for a paradigm shift in #MolecularDynamics data management.
Read more here ➡️ https://f.mtr.cool/prgasqrqyx
📌 DOI: 10.1038/s41592-025-02635-0
#IRBScience 🧪
Un tipo de células del sistema inmunitario potencia la #inmunoterapia y previene la recaída del #cáncer en modelos animales
✍️Ignacio Heras-M @swculek.bsky.social @sancholab.bsky.social et al.
📰 @naturecomms.bsky.social
➡️ https://bit.ly/4lxemWq
📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706
🧪
🙏 Thank you to all participants for joining us over these three truly inspiring days at the 43rd #BarcelonaBioMed Conference on #AI in #DrugDiscovery & Biomedicine!
Don't miss this recap of the conference:
▶️ youtu.be/AAl9jc77YXY
🧵👇
🧪#IRBBarcelona scientists identify a new role for the protein Headcase (HECA), which is crucial for cell protection against oxidative stress.
✍️ Delia Ricolo, Panagiotis Giannios, Jordi Casanova et al.
📰 Science Advances
➡️ https://shorturl.at/zh812
📌 https://doi.org/10.1126/sciadv.ads2086
Many thanks to Dr. Toni Riera for today’s amazing #Descrubre session!
We explored the fundamentals of chemistry with clarity, energy, and inspiration—a true masterclass that has sparked curiosity and deepened our understanding.
Grateful for your
passion and expertise, Dr. Riera! 👏👏👏