Efficiency vs. Specificity? #BroadInstitute's new Jacquere library says: "Why not both?" 🧬✨ Published in #CellGenomics, the Doench team introduces a data-driven balance using the aggregate CFD threshold of 4.8. It rescued 97 essential genes missed by previous libraries! 🌽📈
#CRISPR #GeneEditing

Thanks for highlighting this #CellGenomics research!

Their analysis shows that commensal leopard cats lived in human settlements at least 5,400 years ago and persisted until 150 CE, while domestic cats entered China around 730 CE through Silk Road routes.

#PKUResearch #PekingUniversity #AcademicSky #CellGenomics #Cats

Leopard cats lived commensally with humans in ancient China for over 3,500 years before domestic cats were introduced via Silk Road merchants around 1,400 years ago. Ancient DNA shows that while two small felids once occupied anthropogenic environments, only domestic cats became fully domesticated and globally distributed.

"The late arrival of domestic #cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism" spkl.io/63320AdF6i

He Yu, @joel-alves.bsky.social, @gregerlarson.bsky.social, Shu-Jin Luo & colleagues
#CellGenomics

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation. #GenomicRegulation #Genomics #SingleCell #RNAseq #CellGenomics 🧪🧬 🖥️
www.cell.com/cell-genomic...

Galaxy single-cell & spatial omics community update: Navigating new frontiers in 2025. #SingelCellOmics #SpatialOmics #Genomics #Bioinformatics #Training #Galaxy #CellGenomics 🧪🧬 🖥️
www.cell.com/cell-genomic...

Dusa’s study is on the cover of this month’s #CellGenomics! Check it out if you haven’t had the chance yet!

www.cell.com/issue/S2666-...

#CellTypeAnnotation

SIMS
Scalable, Interpretable Machine learning for Single cell
github.com/braingeneers...

TabNet attention-based
Temperature scaling of trained network
Automated gene intersection

vs Seurat scANVI scVI Scnym Scibet SingleR scBERT

#CellGenomics 2025
www.cell.com/cell-genomic...

Long non-coding RNAs reveal an unexpected way to regulate gene expression Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

P. Sumazin, H-S Chiu, S. Somvanshi et al discovered an unexpected way long noncoding #RNA regulates #geneExpression. #cancer #BigHorn @bcmhouston.bsky.social #TexasChildrens #CellGenomics @rnasociety.bsky.social phys.org/news/2025-08...

Long non-coding RNAs reveal an unexpected way to regulate gene expression The findings revealed that lncRNAs seem to regulate gene expression in a coordinated manner that had not been seen before.

P. Sumazin, H-S Chiu, S. Somvanshi et al discovered an unexpected way long noncoding #RNA regulates #geneExpression #cancer #BigHorn @bcmhouston.bsky.social #TexasChildrensHospital #CellGenomics blogs.bcm.edu/2025/08/05/f...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

@agacita.bsky.social & I preview: "Parental autoimmunity genetics & offspring T1D risk" www.cell.com/cell-genomic... for new #CellGenomics study: "Effects of parental autoimmune diseases on T1D in offspring can be partially explained by HLA & non-HLA polymorphisms" www.cell.com/cell-genomic...

Extensive differential gene expression and regulation by sex in human skeletal muscle Hanks et al. leveraged bulk and single-nucleus RNA-seq and single-nucleus ATAC-seq data from 281 skeletal muscle biopsies to identify widespread sex differences in gene expression and regulation at th...

New #CellGenomics paper: Extensive differential gene expression and regulation by sex in human skeletal muscle. #Myoblue tinyurl.com/43yrj6kp

🧬 New tool to generate aneuploidies and analyse their impact on development.

The tool created by @milanlab.bsky.social helps better understand this phenomenon, which is the main cause of spontaneous miscarriage.

📰 Published in #CellGenomics by #IRBBarcelona

Read the news ➡️ shorturl.at/Ektif

👇

📄The journal #CellGenomics publishes a study with the participation of groups Corominas and Serras @geneticsub.bsky.social on "Sequential activation of transcription factors promotes liver regeneration through specific and developmental enhancers" #PapersBiologiaUB

🔗 www.cell.com/cell-genomic...

Leveraging genomes to support conservation and bioeconomy policies in a megadiverse country Vilaça et al. described a unique private-public initiative, the Genomics of the Brazilian Biodiversity (GBB) consortium. They outline the goals and challenges faced so far and discuss the gaps concern...

Leveraging genomes to support conservation and bioeconomy policies in a megadiverse country. #Genomics #BiodiversityConservation #GenomicsBrazilianBiodiversity #CellGenomics 🧬
www.cell.com/cell-genomic...

#RaynaudsSyndrome GWAS
GTEx-eQTL scRNAseq ISH->
ADRA2A/α2 Adrenergic receptors->
Expressed in distal coronary/skin arteriolar #SmoothMuscleCell

⏫SMC contractility under cold stress (28°C)
SNP CRISPR to modulate transcript level

#CellGenomics 2024
www.sciencedirect.com/science/arti...