@mads100tist.bsky.social continues his takeover in this insightful webinar 🤩 Please do attend, if interested (which you are)!

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

Machines on Genes 2026
8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷

Two deadlines coming up on 8 April 2026

i. abstract submission
ii. early bird submission (save €50)

Four days of 🧑‍🔬🧬👩‍🔬☀️👨‍🔬🔬❄️🧪🧫

94th Harden Conference by @lapassmore.bsky.social, Dana Branzei, me with @biochemsoc.bsky.social.

Great conference, great science and great location!

q.e.d Science Critical Thinking AI for constructive criticism and science evaluation

🤖AI tools for peer-review?

I want to share my experience using q.e.d. science (www.qedscience.com), a reviewing tool with high-profile endorsements. I will report results and my impressions from the use /1

Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series Friday, April 10, 2026, 3:00pm - 4:00 pm Eastern Time Joaquín Navajas Acedo (Biozentrum at the University of Basel) Spatiotemporal emergence of somatosensory neuron diversity in zebrafish Yiqun Wang (University of California, San Diego) Asymmetric mRNA partition mediated embryonic patterning in spiralian development revealed by spatial transcriptomics

The next the Ethel Browne Harvey Postdoc Seminar will be held Friday, April 10 at 3 pm Eastern Time with Joaquín Navajas Acedo @mads100tist.bsky.social @biozentrum.unibas.ch and Yiqun Wang @ucsandiego.bsky.social. Register today and join us. bit.ly/42xUhYh #SDBPostdocSeminar

The E3-ome gene-centric compendium reveals the human E3 ligase landscape The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

Now online! The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...

AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions
📄 research.nvidia.com/labs/dbr/ass...
🌐 alphafold.ebi.ac.uk

Scientific datasets are riddled with copy-paste errors Initial results from scanning through Excel files belonging to 600 published scientific papers.

Markus Englund built a tool for identifying repetitive sequences in scientific datasets! Read up here: www.sciencedetective.org/scientific-d...

Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication - Nature PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

A study published in Nature has identified a new mechanism that controls DNA’s ability to replicate – and thereby a cell’s ability to divide. A protein, PAF15, acts as the brake, preventing the replication machinery from becoming overloaded and protecting cells from replication catastrophe. 🧪

Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial
impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis.
#AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria

www.nature.com/articles/s41...

You are passionate about ubiquitin, proteostasis and cellular biochemistry and want to be part of a collaborative, ambitious, excited and fun team? I am recruiting PhD students via the @imprs-lm.bsky.social graduate school:
www.imprs-lm.mpg.de/index.php/le...
(2/3)

Tomorrow (Tue 3rd)!
PLEASE NOTE THE ALTERNATIVE ZOOM LINK! 👇

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

Our Science paper is out! 😃

www.science.org/doi/10.1126/...

This just in. So honored and grateful...

Two new papers from the lab published in The EMBO Journal!

link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading

link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1

Trove of Mexican genomes could help guide prescribing decisions Study reveals role of “fine-grained” ancestry in predicting response to painkillers, statins, and other drugs

Trove of Mexican genomes could help guide prescribing decisions | Science | AAAS www.science.org/content/arti...

The new cover and feature @nature.com www.nature.com/immersive/d4...

Developing super-tortillas to address malnutrition in Latin America Mexican food scientist Raquel Gómez-Pliego works to improve the nutritional value of foods through microbial fermentation.

Developing super-tortillas to address malnutrition in Latin America www.nature.com/articles/d41...

New year, new preprint! 🎊

We are excited to share our recent work on #E3 ligase regulation in #metabolism!

www.biorxiv.org/content/10.6...

#ubiquitin #targetedproteindegradation #chemicalbiology

1/6

🔍 #AskZebrafish: Does anyone in the US or Canada have any of the following mutant #zebrafish lines and would be willing to share?

tert, klotho, cxcl12a, cxcl12b, cxcr4a and cxcr4b

Any leads would be appreciated! (Yes, we know ZIRC has some frozen but trying to find live)

Have you ever thought to yourself, 'I wish I had a bibliography with 50 carefully arranged references, each one showing a different way AI is making everything worse, perhaps with selected quotations from each reference'? Do I have good news for you"

sharonkabel.com/genai-fraud

Check out the newest preprint from the Schulman lab 🎊🎉

Super cool mechanism of how a metabolite regulates the stability of its own metabolizing enzyme!

Alina did it all for this project CRISPR screen ✂️, biochemistry 🧪, and cryo-EM ❄️🔬.
Congrats!

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

I was a ‘go, go, go’ academic. A fellowship abroad transformed my approach “I came back with a recalibrated sense of how I want to live and work,” this professor writes

I was a ‘go, go, go’ academic. A fellowship abroad transformed my approach | Science | AAAS www.science.org/content/arti...

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Our @costerlab.bsky.social review is out!

It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!

www.sciencedirect.com/science/arti...

@adityasethi.bsky.social @billiedelpino.bsky.social