Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

Professor in Synthetic Organic Chemistry University of California, Irvine is hiring. Apply now!

Please RT!

The Dept of Chemistry at UC Irvine invites applications for a tenured faculty position in Synthetic Organic Chemistry. Deadline: July 1, 2026.

More information about the position can be found here: recruit.ap.uci.edu/JPF10109

@uciphyssci.bsky.social

Recent advances in the strain-release driven reactions of bicyclobutanes: an emerging landscape in organic synthesis Bicyclo[1.1.0]butanes (BCBs) are among the smallest and most strained carbocycles and have emerged as powerful synthetic building blocks in modern organic chemistry. Recent years have witnessed a surge of interest in understanding and exploiting their unique reactivity. The high strain energy associated with the ce

Learn more about bicyclobutanes with this new Tutorial Review by Shiksha Deswal, Rohan Chandra Das and Akkattu T. Biju!

"Recent advances in the strain-release driven reactions of bicyclobutanes: an emerging landscape in organic synthesis"

Read the full review here 👉

Eradicating tumors with a mRNA vaccine in the experimental model
www.pnas.org/doi/10.1073/...

Self-driving labs are transforming chemistry; but high cost & complexity limit access to a few well-funded labs.

We wanted to change that.

Our new paper in #NatureSynthesis introduces RoboChem-Flex 🧪🤖

🔗https://nature.com/articles/s44160-026-01053-0

#selfdrivinglab #flowchemistry #optimization

NSF announces 2026 Graduate Research Fellowship Program award offers The U.S. National Science Foundation (NSF) today announced that it has made offers and will award 2,500 Graduate Research Fellowships for the 2026-2027 academic year...

What a #fantastic day for #science and #young #minds -this is such a #great #news www.nsf.gov/news/nsf-ann...

Another example—this time from my own history—of incremental improvement in drug discovery. In 1988 it was discovered in Oxford that deoxynojirimycin (DNM), an α‑glucosidase inhibitor found in… | Stan... Another example—this time from my own history—of incremental improvement in drug discovery. In 1988 it was discovered in Oxford that deoxynojirimycin (DNM), an α‑glucosidase inhibitor found in mulberr...

Do you want to hear the exciting and insightful stories behind drug discovery?

Lately, Stan Van Boeckel, emeritus professor at @leidenscience.bsky.social and @led3hub.bsky.social , has started a series of #SciComm posts on this topic. (1/4)

www.linkedin.com/posts/stan-v...

Interesting #lipidtime food science: eating melted cheese increases your triglycerides and cholesterol more than eating the *exact same cheese* unmelted — possibly due to changes at the molecular level in a phospholipid *trilayer* that encapsulates fat in dairy products!

Glad to share our new work: RitS (Right into the Saddle): a generative model for direct transition state (TS) prediction.
📄 Paper: chemrxiv.org/doi/full/10.26…
🤠 Code: github.com/isayevlab/RitS
• Flow-matching model with explicit stereochemistry control
• Direct TS generation from SMILEs #compchem

Divergent and programmable skeletal remodeling of complex macrocycles with a small method set The bioactivity of complex organic macrocycles can vary unpredictably with their three-dimensional structural contours. Here, we present a streamlined, programmable and systematic strategy for skeleta...

In @science.org for chemsky, Amir Hoveyda's group report a remarkably streamlined approach to precise expansion or contraction of macrocycles

www.science.org/doi/10.1126/...

Review @cp-trendsimmuno.bsky.social
Trained immunity responses across infectious diseases and cancer vaccines
www.sciencedirect.com/science/arti...

A unified platform for nucleoside analog synthesis Nucleoside analogs (NAs) are essential as antiviral and anticancer therapies. Despite decades of focused medicinal chemistry efforts, their related chemical space remains underexplored, mainly due to ...

This is massive...

www.science.org/doi/10.1126/...

▶️Submit your abstract for a Flash Talk at the 6th Virtual ChemBio Talks (Sept. 29, 2026): chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

📅Deadline: June 15, 2026

@chembiotalks.bsky.social Sponsored by #ChemBioChem and Chemistry Europe

We are pleased to share our new work in @pnas.org investigating the discovery, biosynthesis, and mechanistic investigation of a class of molecules we call spirocyclic beta-lactones! Skeetorial to follow. #natprod 🧪
www.pnas.org/doi/full/10....

Allergy season reminder: Allegra (fexofenadine) only exists because its predecessor, terfenadine, caused fatal heart arrhythmias via QT prolongation. Turns out terfenadine was just a prodrug - fexofenadine was doing all the work. A safer drug was hiding inside a dangerous one. #DrugDiscovery

Skeletal editing by iron-catalyzed carbene insertion of trichloromethanes Direct interchange between five- and six-membered nitrogen heterocycles by skeletal editing is valuable in drug discovery. Specifically, inserting a c…

Back in 2019 I wrote my first grant, for the ACS PRF, in which I proposed carbon insertion into LSD (truly a pipe dream at the time). After teaming up with @nagiblab.bsky.social and @deolsonlab.bsky.social, the dream is finally a reality!

www.sciencedirect.com/science/arti...

A high-affinity split-HaloTag for live-cell protein labeling Nature Communications - Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse...

A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...

Glycosylation as a dynamic regulator of RLR and cGAS-STING innate immune signalling pathways - Communications Biology The authors review the role of glycosylation and its subtypes in DNA and RNA-sensing pathways within host innate immunity.

Review: Glycosylation as a dynamic regulator of RLR and cGAS-STING innate immune signalling pathways
www.nature.com/articles/s42... @ucalgary.bsky.social

Analysis of heterocycle formation and stereochemical control by a non-ribosomal peptide synthetase condensation domain - Nature Synthesis The condensation domain PvdL-C3 is shown to synthesize the tetrahydropyrimidine ring of pyoverdine, revealing cyclization capability in a canonical non-ribosomal peptide synthetase domain. Structural ...

Now online:

Article by Zhijun Wang & co-workers

Analysis of heterocycle formation and stereochemical control by a non-ribosomal peptide synthetase condensation domain

www.nature.com/articles/s44... ($)
#Chemsky

Mitochondrion generated by AI in the styles of Salvador Dali

Good morning mitolovers! Another beautiful week of papers in #cancermetabolism and #mitochondrialbiology has passed. Don't miss the curated list, find it here: biomed.news/bims-camemi/... Biomed News #keepreading

"The meaning of being alive is just being alive." -Alan Watts

Triacylglycerol synthesis in T cells is essential for male, but not female, antitumour immune responses through sequestration of toxic lipids increased by androgen receptor signalling @natmetabolism.nature.com www.nature.com/articles/s42...
www.nature.com/articles/s42...

Generalist biological artificial intelligence in modeling the language of life - Nature Biotechnology This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across bi...

AI to understand the language of life.
Our review just published
nature.com/articles/s41...
Free access rdcu.be/e89lQ

Highlights of cyanobacterial metabolites reported between 2021–2024 Covering: 2021 to 2024This review highlights cyanobacteria secondary metabolites reported between 2021 and 2024. Those compounds are categorised into major classes, including peptides, alkaloids, lipi...

Our highlight review on recently isolated cyanobacterial metabolites is out @natprodreports.rsc.org !🥳 Covers isolation, structure elucidation (analytical techniques, biosynthesis and total synthesis). Great work with @elisabethjanssen.bsky.social!
@chem.uzh.ch

pubs.rsc.org/en/content/a...

What we should be doing, but we're not:
"Arming the immune system for the next zoonotic coronavirus spillover"
A nasal dendritic-cell targeting vaccine that prevents viral transmission vs pan-sarbecovirus clades (i.e. all coronaviruses, irrespective of variants)
www.jci.org/articles/vie...

Review: The dual roles of natural killer cells in liver immunity and tolerance: Implications for health and disease
journals.lww.com/hepcomm/full...

Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cells
journals.plos.org/plosone/arti...

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

Heteronuclear dual-atom insertion into oxetanes via frustrated Lewis pair activation - Nature Synthesis A boron-catalysed heteronuclear dual-atom insertion into oxetanes via frustrated Lewis pair activation is reported, providing access to a series of valuable 1,3-oxazinanes. This approach exhibits broa...

Now online:

Article by Ying-Qi Zhang, Shuo-Han Li & Ming Joo Koh

Heteronuclear dual-atom insertion into oxetanes via frustrated Lewis pair activation

www.nature.com/articles/s44... ($)
#Chemsky

Diversify and conquer: Antibody feedback in the germinal center Pre-existing antibodies restrict naive B cell entry into germinal centers, but how antibody feedback shapes ongoing reactions is unclear. In this issue of Immunity, Barbulescu et al. and Yan et al. sh...

Antigen binding by locally produced high-affinity antibodies promotes epitope diversification, thereby broadening the humoral response @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...

Endoplasmic reticulum–mitochondria contact sites are signalling hubs connecting nutrient sensing and GLP-1 secretion in L cells of the mouse gut: from physiology to obesity and type 2 diabetes - Diabe... Aims/hypothesis Postprandial glucagon-like peptide-1 (GLP-1) secretion by enteroendocrine L cells of the gut plays an important role in glucose homeostasis, thus representing a therapeutic option of e...

ER–mitochondria calcium coupling is essential for glucose-induced GLP-1 secretion in L cells @diabetologiajnl.bsky.social
link.springer.com/article/10.1...