How do different long-read sequencing technologies actually stack up?
Our latest Sequencing 101 blog update compares the leading platforms across accuracy, cost, and application fit to help you choose the right fit for your lab.
See the #PacBio difference here: bit.ly/46cQMqR
Traditional cancer testing workflows can be slow, fragmented, and costly. 🧬
Discover how SPRQ-Nx chemistry enables assay consolidation, reducing laboratory costs and shortening the path to answers with a single HiFi genomic workflow.
Read more: bit.ly/4t3MQ6x
#PacBio #AACR26 #SPRQNx
From DNA to discovery: what are the steps of HiFi sequencing? 🧬
This blog breaks down the 5-step PacBio workflow, covering everything from Nanobind sample prep to real-time data analysis on the Revio and Vega systems.
See how it all comes together: bit.ly/4vDRhGW
#PacBio #HiFisequencing #Genomics
Did you know it costs us $64 a month to host Biology PhD stipends?
Excited for this upgrade which takes our hosting costs to $0!
mlgaynor.com/BiologyPhDSt...
We gave early access of SPRQ-Nx chemistry to a select group of scientists.
Watch how beta testers like Katy Munson from University of Washington see the workflow and economic benefits of what’s next for #PacBio HiFi sequencing.
On-demand webinar: bit.ly/4szZAS9
#SPRQNx #HiFisequencing
Long reads carry multiple small vars and SVs and their phasing. LongcallD is the only caller that tightly integrates germline/mosaic small/structural vars/MEIs and their phasing in a single C program. One command line to get competitive small variant calls and better SVs. Led by Yan Gao.
First @molecology.bsky.social 's special issue in December (onlinelibrary.wiley.com/toc/1365294x...), and now this! Inspiring to see so many talented scientists working at the intersection of evobio, genomics, and applied conservation. Great for your reading lists!
Cancer sequencing 101 is back! Today's lesson: Epigenetics.
Watch the next video in the series to learn how researchers use DNA methylation and chromatin accessibility information from HiFi sequencing to power their discoveries.
Full video here: bit.ly/4sjQrgd
#PacBio #CancerResearch #Epigenetics
PacBio is proud to partner with Basecamp Research to generate high-fidelity metagenomic data for the Trillion Gene Atlas, a landmark initiative to model biological data at the trillion-gene scale and accelerate AI-designed therapeutics.
Learn more here: bit.ly/479RQh3
#PacBio #TrillionGeneAtlas
Excited so share our newest study using a single-library HiFi-CiFi approach to generate chromosome-scale diploid assemblies of two vole genomes, identifying putative drivers of divergent pair-bonding behavior, namely a prairie-vole-specific duplication of Avpr1a gene, led by @mabuelanin.bsky.social
HiFi = accuracy. But how?
HiFi reads are generated by combining multiple passes around a single DNA molecule. By merging repeated observations, the system produces long reads with greater than 99.9% accuracy.
Watch the full video to see under the hood: bit.ly/3YSPBdo
#TheresHiFiForThat #PacBio
Discover more, find more answers, and even potential cancer treatments HiFi sequencing — from isoforms and gene fusions to structural variants and epigenetics.
Check out this video series on key publications highlighting the power of HiFi sequencing in onocology compared to short-reads!
How can HiFi sequencing unlock deeper insights into cancer biology than short reads for gene fusions and isoforms?
Our new series shows how researchers use #PacBio to drive discoveries in methylation and structural variation.
Watch here: bit.ly/3P78pnA
#CancerResearch #HiFisequencing
A new paper in Cell Genomics validates how #PacBio HiFi sequencing unlocks ASD research.
By replacing multiple assays with one workflow, researchers saw a 33% increase in SV detection and a 38% increase in tandem repeat detection.
Read the study: bit.ly/4sAnkFd
#ASD #PacBio #HiFisequencing
How does HiFi capture epigenetics in one run?
When a base is modified, its incorporation rate shifts. HiFi measures these kinetic signatures to detect 5mC and 6mA automatically with no extra library prep.
Watch our newest explainer video to see how: bit.ly/3YSPBdo
#TheresHiFiForThat #PacBio
Decoding cancer requires resolving transcript diversity within intact tissue.
Join our webinar to see how long-read sequencing and near-single-cell spatial transcriptomics reveal isoform diversity and map immune receptor clonotypes in tumors.
Register: bit.ly/4bsBanl
#PacBio #CancerResearch
One molecule. Multiple layers of biology.
HiFi sequencing = multiomic insights.
It reveals the genome, structural variants, full-length isoforms, and base-level methylation. All in one run. All from the same molecule.
Get the full picture: bit.ly/3YSPBdo
#PacBio #HiFisequencing #Multiomics
What happens when a condition shifts from rare to widespread?
In Episode 3 of Beyond the Bench, Dr. Birgitt Scheule explains what it means to shift from studying isolated cases to addressing disease at population scale.
Watch now: bit.ly/4oLrOXu
#BeyondTheBench #PacBio #HiFisequencing
Color the future of genomics at PRISM 2026.
Join us to see how HiFi sequencing evolves in real time. Meet our experts in person and hear research already influencing study design and results for large-scale studies.
Secure your place: bit.ly/4slZxZs
#PacBioPRISM #PacBio
Click the link and watch a short video to learn how HiFi sequencing works — brought to you by PacBio field support team
We've seen a big increase in the number of long-read #metagenomics publications, especially those using #PacBio HiFi data. Also very encouraging to all the new tools for long-read metagenome assembly & taxonomic profiling.
Complete list of publications: github.com/PacificBiosc...
HiFi sequencing can reveal rare and complex variants, but interpretation requires diverse background datasets.
PacBio and DNAstack are supporting the first global federated dataset of HiFi whole genomes through the HiFi Solves Global Consortium.
Details: bit.ly/4kQ0bMk
#WeCareForRare
💖 Feeling Solo this year?
Back by popular demand, Alex Dainis’ dating profile video shows how finding the right sequencing tech can feel like dating, with lots of mismatches before the perfect match.
See why HiFi on Vega is the perfect match + ask about out our new promos: bit.ly/3M6VmBi
Hi Molly! Reach out to Arima or Dovetail if you haven't already!
Thanks to everyone who joined our PacBio workshop today! 🌱🐄
We loved sharing how HiFi sequencing and SPRQ-Nx chemistry are advancing multiomic discoveries across genomes and populations. Stop by Booth #219 to continue the conversation!
#PAG33 #PacBio #PAG2026
The PacBio PAG 2026 party has begun! 🎉🌱🐄 We’re excited for a night of great conversation, connections, and celebrating the collaborations that make plant and animal genomics so inspiring.
#PAG33 #PacBio #PAG2026
Jeremy Schmutz at HudsonAlpha is the last talk of the @pacbio.bsky.social workshop at #PAG33 to talk about the cornucopia of genomics PacBio provides including beta testing results from SPRQ-Nx reusable SMRT Cells.
Christine Queitsch is up at @pacbio.bsky.social workshop at #PAG33 to talk about Fiber-Seq in Maize to look at chromatin accessibility, protein occupancy, and nucleosome positioning from a single HiFi experiment along with your long read sequencing data. @epicypher.bsky.social
Christine Queitsch walks us through Fiber-Seq in maize which is greatly increasing our understanding of the regulatory landscape of maize.
Brooke Peterson-Burch up next at @pacbio.bsky.social Workshop at #PAG33 to talk about gene prediction in crops using Kinnex Iso-Seq.
