Manu Hegde smiling wearing a red jumper

Congratulations to Manu Hegde, Group Leader & Joint Head of @cellbiol-mrclmb.bsky.social, who has been elected a member of the American Academy of Arts & Sciences.

Congratulations also to the #LMBalumni joining him, Julie Ahringer & Edward Egelman.

Read more: mrclmb.ac.uk/news-events/...
#LMBNews

Congrats @mjafreeman.bsky.social !

The Biochemical Society 2027 Centenary Award presented to Professor Matthew Freeman from University of Oxford, UK.

A leader in the cell biology of signalling, the 2027 Centenary Award is presented to Matthew Freeman in recognition of his pioneering discoveries into the biological significance and mechanisms of rhomboid intramembrane proteases and pseudoprotease and unwavering commitment to mentorship!

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳

With Michel Goedert and Masato Hasegawa.

www.biorxiv.org/content/10.6...

Interspecies interactions drive bacterial proteome reorganization and emergent metabolism - Nature Ecology & Evolution An analysis of the responses of 15 diverse human gut bacteria in more than 100 pairwise co-cultures reveals extensive remodelling of the bacterial proteome and metabolome in response to the presence o...

Check out our new paper applying fast DIA proteomics to bacterial co-cultures at scale. www.nature.com/articles/s41...
@kiranrpatil.bsky.social

CITIID Research Highlight: Lalita Ramakrishnan See the story

Tuberculosis remains the world’s deadliest infectious disease.
Lalita Ramakrishnan’s group, @cellbiol-mrclmb.bsky.social & @medcambridge.bsky.social, studies how TB thrives, including what drives its drug tolerance.
Read more: new.express.adobe.com/webpage/GdOa...
#LMBintheNews #WorldTBDay #EndTB

Training a force field for proteins and small molecules from scratch Force fields for molecular dynamics are usually developed manually, limiting their transferability and making systematic exploration of functional forms challenging. We developed a graph neural networ...

Check out our pre-print, where we train a protein and small molecule force field from scratch with a graph neural network.

We show comparable performance to existing, manually-tuned force fields on a range of tasks including binding free energy prediction. (1/4)

arxiv.org/abs/2603.16770

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.

#OpenSoftwareAcceleratesScience

Interested in one of the top jobs in European biology?

@embo.org has opened a call for its next Director, to succeed Fiona Watt

Really spectacular opportunity! Spread the word...

www.embo.org/features/emb...

Join #EMBOCryoEM to get a comprehensive foundation in advanced single-particle and cellular tomography techniques – we'll cover the entire workflow from sample preparation to data collection and image processing.

https://s.embl.org/cry26-01-bl
Apply by: 11 May 2026
@embo.org

BBC Radio 4 - In Our Time, Archaea How a discovery in the 1970s changed the theory of the origin of complex life on earth.

Archaea hit prime time: www.bbc.co.uk/programmes/m...

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

How did life arise from simple chemical building blocks?

New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.

Read more: mrclmb.ac.uk/news-events/...

congrats Kelly, so well deserved!

Research Group Leader Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

We are hiring for group leaders again — EBI is a great place to start your research group!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

A reminder to sign up for the 2026 EMBO archaeal meeting im Cambridge: meetings.embo.org/event/26-arc.... Registration is open. We are looking forward to hosting you!

Sign up now for the EMBO Workshop "#MolecularBiology of #Archaea: Life Through the Prism of Archaea" in Cambridge, UK, 6–10 July 2026.

Deadline: 15 April

https://meetings.embo.org/event/26-archaea
#EMBOArchaeaBiology #EMBOevents #CellBiology #StructuralBiology #ecology #evolution #biophysics 🧪

We have an opening for a research support officer. Come and join us! Please share.

Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?

Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.

Sign up: meetings.embo.org/event/26-arc...

We look forward to seeing you in Cambridge, UK.

Please repost!

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.

mrc.tal.net/vx/mobile-0/...

Top UK scientist says research visa restrictions endanger economy Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.

BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...

Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...

Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet

🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain

📝Program and registration info: meetings.embo.org/event/26-bac...

👩‍🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social

#MicroSky

Deaths linked to antibiotic-resistant superbugs rose 17% in England in 2024 Data also shows an average of nearly 400 newly reported cases of antibiotic-resistant infections a week last year

‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...

Pleased to share our review on S-layers with @bupbuse.bsky.social, Andriko von Kügelgen, and @tbharat-lab.bsky.social, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization. @mpi-bio-fml.bsky.social

Introduction to microbial surface layers (S-layers) YouTube video by MRC Laboratory of Molecular Biology

Also see the associated primer video on S-layers made by the @mrclmb.bsky.social Visual Aids department Konstantinos Alexandrou and Shraddha Nayak!

www.youtube.com/watch?v=fgSf...

Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...

Assembly, architecture and functional roles of microbial surface layers

Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.

S-layers are everywhere!

www.nature.com/articles/s41...