Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits

Stable, sustained support can transform your career:

Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

mRNA vaccines engage unconventional pathways in CD8+ T cell priming - Nature mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and ...

Type 1 IFN primes cross-dressing of cDCs with peptide–MHC-I complexes from non-haematopoietic cells, explaining ability of mRNA vaccines to activate CD8+ T cells against antigens not encoded by the vaccine @nature.com @washumedicine.bsky.social #Murphy
www.nature.com/articles/s41...

@biorxivpreprint.bsky.social PD-1 blockade enhances T cell activation by reorchestrating CD28 and CTLA4 ligand interactions @astra-zeneca.bsky.social
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancer @biology-unige.bsky.social
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social The role of integrins in T cell-mediated resistance to Cryptosporidium parvum
www.biorxiv.org/content/10.6... @i3h-upenn.bsky.social @kingofpathogens.bsky.social

Purine salvage pathway protects CD8+ T cells from metabolic stress - Nature Immunology Tajima et al. show that a transient or continuous high-fat diet induces metabolic changes in CD8+ T cells that lead to increased vulnerability to ferroptosis and reduced antitumor responses.

New paper from CCII researchers Masaki Tajima, Sidonia Fagarasan et al: a purine salvage pathway that helps CD8 T cells cope with metabolic stress and fend off ferroptosis.
#Immunology #Metabolism
@natimmunol.nature.com
www.nature.com/articles/s41...

Spatial TCR profiling has the potential answers to key questions in cancer immunology, including revealing spatially coordinated T cell states in head and neck cancer @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @bcmfromthelabs.bsky.social

Lipid-rich tissues trigger lipid droplet-dependent, gasdermin D-mediated pyroptosis in metabolically exhausted CD4+ T cells, thereby sustaining inflammatory pathology @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...

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A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation @natimmunol.nature.com
www.nature.com/articles/s41...

Unveiling the molecular architecture of T cells and immune synapses with cryo-expansion microscopy Cytotoxic T cell killing is executed at the immunological synapse, whose nanoscale organization underlies function but remains difficult to resolve in…

Unveiling the molecular architecture of T cells and immune synapses with cryo-expansion microscopy.

wow. really cool imaging here. especially if you like immune cells

www.sciencedirect.com/science/arti...

Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment Regulatory T (Treg) cells are phenotypically stable in inflammatory settings. Maltez et al. report that αCD40 immunotherapy induced conversion of Treg cells into FoxP3−Tbet+IFN-γ+ “ExTreg” cells within the tumor microenvironment. ExTreg cells exhibited increased antigen reactivity and spatially associated with Cxcl9+dendritic cells in the tumor periphery, suggesting plasticity and anti-tumor potential.

Online now: Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment

Sulfur partitioning from cysteine controls T cell proliferation and effector function This study pinpoints cysteine’s sulfur as a key determinant of CD8+ T cell immune function. Intracellular cysteine partitioning between glutathione and iron-sulfur metabolism is a critical metabolic decision that controls T cell proliferation and effector function.

Now online! Sulfur partitioning from cysteine controls T cell proliferation and effector function

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation How Foxp3 establishes the epigenetic and transcriptional identity of regulatory T (Treg) cells remains unclear. Murakami et al. demonstrate that Foxp3 cooperates with the AP-1 transcription factor BATF to directly promote chromatin accessibility and gene expression in effector Treg cells, revealing a state-specific mechanism by which Foxp3 directs Treg cell identity.

Online now: Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation

major issues with antibodies used in #neuroscience research
www.thetransmitter.org/open-neurosc...
#reproducibility

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

It’s well known that inflammation increases cancer risk, but how?

The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.

Here is our paper: nature.com/articles/s41...
And a special shoutout to the lead author
@snaga13.bsky.social

A 🧵

Chemokine-defined macrophage niches establish spatial organization of tumor immunity - Nature Immunology Jakubzick and colleagues show that the tumor microenvironment is shaped by opposing programs in tissue-resident CD206hi and CD206lo interstitial macrophages and Ly6c2+Fn1+Vcan+ recruited macrophages, ...

more beautiful work by @claudjak.bsky.social lab. www.nature.com/articles/s41...

MHC class I on target cells regulates CD4+ T cell-mediated immunity @natimmunol.nature.com
www.nature.com/articles/s41... @bcmfromthelabs.bsky.social

Triacylglycerol synthesis in T cells is essential for male, but not female, antitumour immune responses through sequestration of toxic lipids increased by androgen receptor signalling @natmetabolism.nature.com www.nature.com/articles/s42...
www.nature.com/articles/s42...

Preprint: Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8⁺ T cells www.researchsquare.com/article/rs-8...

New from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. rupress.org/jem/article/...

#Immunology #Mitochondria #Ak4

Some molecular machines, like ribosomes, can persist for long periods of time in cells.

Could molecular aging of ribosomes shape how proteins are made?

In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

www.biorxiv.org/content/10.6...

Review @cp-trendsbiochem.bsky.social
Regulation of inflammatory gene transcription by ubiquitination and deubiquitination
www.cell.com/trends/bioch...

Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection @natimmunol.nature.com @rockefeller.edu @biohub.org @danmucida.bsky.social @rohamparsa.bsky.social
www.nature.com/articles/s41...

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity @nature.com www.nature.com/articles/s41...

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding @nature.com @danafarber.bsky.social @harvardmed.bsky.social @judithagudo.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...

New research out in Nature Immunology finds that tissue-resident exhausted & memory CD8+ T cells have distinct ontogeny, function & role in disease ft. Simone Park & @ejohnwherry.bsky.social (Systems Pharmacology & Translational Therapeutics/ @i3h-upenn.bsky.social) www.nature.com/articles/s41...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Happy to share our new paper in @febsj.bsky.social! With
@ondrej-kuda.bsky.social & @fedorovalab.bsky.social we show how #LipidDroplets reshape the lipidome of PUFA-exposed cells, but can also shift function within the same cell, revealing a context-dependent role in #ferroptosis. shorturl.at/TyRl1