The cover shows a colored transmission electron microscope image of rotavirus, an enteric pathogen.

This week's issue of #ScienceTranslationalMedicine is out!

Patient-specific inflammatory "entotypes" may predict outcomes in severe trauma, deep sequencing identifies a gene variant that may drive early obesity in young adults, and more. https://scim.ag/4kyuFm7

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

Mapping the metabolic effects of drugs helps define their mode of action go.nature.com/3CreANg
rdcu.be/eUK7o

I am grateful to share that I have been appointed as the PhD Graduate Program Director for UMB Pharmaceutical Sciences at the University of Maryland School of Pharmacy.

Our application deadline for PhD has been extended to Dec. 15. lnkd.in/eqhKuytA
Apply today!

A brief guide to studying extracellular vesicle function in the context of metabolism - Nature Metabolism Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.

#Throwback 🧪

COMMENT | A brief guide to studying extracellular vesicle function in the context of metabolism

C Crewe et al

The University of Maryland School of Pharmacy (UMSOP) in Baltimore is recruiting new students for PhD and MS programs. Come join us and apply today! www.pharmacy.umaryland.edu/academics/ps...

This is figure 4, which shows protein–protein network analysis reveals protein networks involved in pwMS.

Myelin damage in multiple sclerosis can be detected up to seven years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis, according to a paper in Nature Medicine. go.nature.com/4qqq47L #medsky 🧪

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis - Nature Metabolism The authors provide a comprehensive characterization of how glutamine uptake and utilization regulate macrophage function in atherosclerosis.

RESEARCH | S Benhmammouch, L Yvan-Charvet et al. (Univ Côte d’Azur)

Glutamine uptake and utilization regulates macrophage function in atherosclerosis 🧪

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

#Throwback 🧪

COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics

KS Lee, X Su & T Huan

On the pathogenesis of obesity: causal models and missing pieces of the puzzle - Nature Metabolism This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis and by defining terms that are at the core of this discussion.

#Throwback 🧪

PERSPECTIVE | On the pathogenesis of obesity: causal models and missing pieces of the puzzle

F Magkos, @kevinh-phd.bsky.social , @johnspeakman4.bsky.social , A Astrup et al
‪
www.nature.com/articles/s42...

Fig. 1: Reversal of HFCS-induced metabolic dysfunctions by inulin supplementation.

A study in Nature Metabolism shows that the dietary fiber inulin modifies the gut #microbiome to better process fructose, helping prevent metabolic dysfunctions and emphasizing the role of dietary fiber. go.nature.com/4gKCvHe 🧪

Artificial intelligence-assisted academic writing: recommendations for ethical use

advancesinsimulation.biomedcentral.com/articles/10....

Futile lipid cycling: from biochemistry to physiology - Nature Metabolism Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.

#Throwback 🧪

REVIEW | Futile lipid cycling: from biochemistry to physiology

C Wolfrum et al.

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

The immune response

Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation Lin et al. discover homocysitaconate, an anti-inflammatory metabolite formed during inflammation via AHCY-catalyzed adduction of homocysteine and itaconate. Homocysitaconate is recognized by MARS, ind...

'Here, we identify the immunometabolic crosstalk that generates homocysitaconate, a metabolite formed by homocysteine & itaconate adduction catalyzed by S-adenosyl-L-homocysteine hydrolase. Homocysitaconate increases 152-fold during #inflammation and exhibits anti-inflammatory effects.'
#Immunology

Join us for #IMES2025!
🚨 Abstract deadline for trainees and early career PI's is coming soon! Due: Aug. 15, 2025
Submit for a chance to present oral talks and for awards!💲
👉Learn more/submit: tinyurl.com/DIMES2025

Congratulations, well-deserved!!

Screenshot of tech job description and responsibilities. Link to full ad is in post.

We're recruiting a lab technician to assist with our ongoing liquid biopsy projects. Please encourage those with relevant experience to apply. Feel free to contact me with questions! tinyurl.com/prattlabtech

A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. He...

COMMENT | ‪🧪

@colbyvorland.bsky.social ‬, L Golzarri-Arroyo & DB Allison (Indiana Uni)

This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses.

www.nature.com/articles/s42...

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

RESEARCH | MH Tschöp, TD Müller et al

@www.helmholtz-munich.de

Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms.

🧪

www.nature.com/articles/s42...

Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo!

We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu

Nanoneedles enable spatiotemporal lipidomics of living tissues - Nature Nanotechnology Arrays of silicon nanoneedles are used to generate molecular replicas of live brain tissue for longitudinal spatial lipidomic classification via desorption electrospray ionization mass spectrometry imaging of gliomas and to monitor the responses of the tumours to chemotherapy.

A paper in Nature Nanotechnology presents a method using arrays of silicon nanoneedles to generate molecular replicas of living tissue, enabling mapping for glioma characterization and classification. The method allows for the monitoring of the response of the tumours to chemotherapy. #medsky 🧪

#Fumarate update

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation

Dual role in Inflammation

Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10

Pro-
mtDNA mtRNA➡️IFNβ

#CellMetab 2025
www.sciencedirect.com/science/arti...

I'm thrilled to share that our lab has been awarded an R01 from NIH NIAID to continue our research to develop new nanoparticle-based immunotherapies for treating sepsis! news.pharmacy.umaryland.edu/umsop-facult...

Similarities in B Cell Defects between Aging and Obesity Abstract. The aging population is increasing worldwide, and there is also an increase in the aging population living with overweight and obesity, due to ch

Dr. Daniela Frasca et al highlight the interesting role of metabolism in #aging by comparing age and obesity in humans. They note that aging and obesity are conditions which can lead to dysregulated immune responses. Learn more: ow.ly/MeGI50W6fLn

Tutorial: guidelines for the use of machine learning methods to mine genomes and proteomes for antibiotic discovery - Nature Protocols In this Tutorial, we provide guidelines for the use of ML models to mine genomes and proteomes for the discovery of antimicrobial peptides, discussing the various stages of the ML workflow, recent advances in ML models and how to experimentally validate the computational predictions.

A Tutorial in Nature Protocols provides guidelines for the use of machine learning models to mine genomes and proteomes for the discovery of antimicrobial peptides. 🔒

Congratulations!!!

Signalling from adipose tissue to the brain is not just about leptin - Nature Metabolism A Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.

NEWS&VIEWS | Peter Arner ( ‪@ki.se‬ )

Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.