👏 and excellent thread! 🙏

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Karolinska Institute is hiring for 9 new positions!

Individual job details below!👇

#ScienceJobs

Thanks Louis !

Truly humbled and deeply honored to have been elected a Fellow of the European Academy of #Microbiology, @femsmicro.org
Profoundly grateful to my mentors, collaborators, colleagues, and students, past and present, whose guidance, creativity, and dedication have shaped this journey 🙏 ♥️

Any idea if she’ll be touring in Toulouse in 2027 or 2028?

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌
We hope these findings will help the fight against drug resistance in tuberculosis.
www.biorxiv.org/content/10.6...

👏👏👏

AI agent Fleming accelerates antibiotic discovery for Mycobacterium tuberculosis by integrating generative and predictive models, achieving 83% in-vitro hit rates and identifying novel compounds with favorable ADMET profiles across unexplored chemical space.

www.biorxiv.org/content/10.1...

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no mu…

New paper out: HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
www.sciencedirect.com/science/arti...

🚨 𝐀𝐈 𝐦𝐞𝐞𝐭𝐬 𝐓𝐁 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲!

Imaging 𝐶. 𝑔𝑙𝑢𝑡𝑎𝑚𝑖𝑐𝑢𝑚 (a model for 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery.

✍️ @awehenkel.bsky.social & coll.
📖 shorturl.at/9QPDy

#Tuberculosis #MicroSky

Our new paper is out in @lsajournal.org
We explored how glycolysis inhibition in tuberculosis-infected macrophages can reduce HIV-1 spread.
🔗 Read it here: doi.org/10.26508/lsa...
Huge thanks to @Zoi Vahlas, @lucianabalboa.bsky.social, @oneyrolles.bsky.social & @chrisverollet.bsky.social

Thank you @embojournal.org! 🙏
The editorial process was genuinely exceptional: thoughtful, collaborative, and constructive. If only all journals had editors who truly act as editors!

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

How can bacterial pathogens weather metal ion stress during infection?
@pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate ‘effluxosomes’, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals
link.springer.com/article/10.1...

Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.

#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire

✍️ @oneyrolles.bsky.social
🤝 @ipbstoulouse.bsky.social
📕 buff.ly/4R5iaMB
▶️

👏 @pierredupuy.bsky.social and colleagues!
@genotoul.bsky.social @agencerecherche.bsky.social @anrs-mie.bsky.social ...
And... @yoannrombouts.bsky.social, inventor of the word "effluxosome"! 😉

Beyond the science, I want to highlight the peer review at @embojournal.org—truly constructive, collaborative, and scientific dialogue that strengthened the work at every step.

Conceptually, this work:
🔬 Introduces effluxosomes as a new paradigm for bacterial membrane organization
🧪 Shows how pathogens coordinate multi-metal resistance
💊 Opens potential avenues for new antimicrobials against tuberculosis.

PacL1 acts as a multi-substrate metallochaperone, and the effluxosomes connect to a broad interaction network—these are not isolated modules but part of a coordinated stress adaptation program.
...

Using single-particle tracking and single-molecule super-resolution microscopy, we show these effluxosomes are highly dynamic, stabilizing metal-export pumps and coordinating resistance to zinc, cadmium & copper.
...

The bacterium assembles dynamic membrane platforms organized by PacL proteins, clustering P-type ATPase pumps into functional complexes we call “effluxosomes.”
...

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥!

After 8 months of revision, our work is now online: shorturl.at/WHmFq

We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection.
...

So inspiring to see the next generation of researchers in action. Their science gets clearer and more impactful every year.

Watching Max Caouaille and Aizat Abdul at #TBVAC was genuinely moving. Great science, great storytelling, huge passion.

The future of research is in very good hands. 👏

The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!

A great meeting ahead for host and pathogen aficionados! Keynote speakers: Florence Niedergang (Cochin) and Raphael Valdivia (Duke)- plenty of opportunities for early career researchers to present their work and a very collegial and supportive network. Belfast here we go! Please repost.

#Immunosky #Glycobiology #Infection #Monocyte

These findings open new avenues for targeting monocyte mobilization in inflammatory diseases, infections, and autoimmune disorders like lupus.
🙌 Huge thanks to the team, and our collaborators! Supported by @agencerecherche.bsky.social, @frm-officiel.bsky.social, and Bettencourt Schueller Foundation.

...
🔹 NCAM1 is the main polysialic acid carrier in inflammatory monocytes, and its loss phenocopies ST8SIA4 deficiency.
🔹 Polysialylation regulates CCR2 surface distribution, cytoskeleton, and chemokine binding, revealing a new mechanism controlling immune cell trafficking.

Key findings include:
🔹 Human 𝑆𝑇8𝑆𝐼𝐴4 variants are associated with lower monocyte and lymphocyte counts and higher SLE risk.
🔹 ST8SIA4 deficiency causes monocytopenia in mice by impairing CCR2-dependent monocyte exit from bone marrow.
...

Inflammatory monocytes are critical for fighting infections (like tuberculosis) and regulating inflammation. We found that the enzyme ST8SIA4, through polysialylation, controls their egress from the bone marrow via the CCR2 receptor, both at steady state and during 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 infection.

🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰.

✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social

📖 shorturl.at/IDwza

👇 A short thread...