Our paper online now #MASH

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Damaged hepatocytes interact witn gamma-delta T cells, and active immune apparatus in #MASH
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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity Dang et al. discover carvedilol, a clinically approved β-adrenergic receptor antagonist, as a STING activator through high-throughput screening. Mechanistically, carvedilol promotes STING dimerization to enhance type I interferon responses. The findings provide the basis for repurposing carvedilol in the therapy of STING-related diseases.

Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

MASLD targets. Learn how different therapies work in #MASH treatment.

journals.physiology.org/doi/abs/10.1...

My continued biomedical education
#MASLD #MASH

Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease

Gut (microbiota)-liver axis

#HepaticStellateCell #Pericyte #YAP/TAZ #GLutaminolysis #Fibrosis

#AJPCellPhys 2025
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Our latest invited review on the pathogenesis of MASLD.

journals.physiology.org/doi/abs/10.1...

Great analysis of the review 👏🏼👏🏼