Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity. Aaron Whiteley
I'm happy to share a review that our lab put together on innate immune responses to Rickettsia. One interesting tidbit - different Rickettsia species have distinct interactions with xenophagy, where some species co-opt ubiquitylation, while others avoid it!
www.sciencedirect.com/science/arti...
Congrats!!
Out now! The latest paper from the lab, spearheaded by Philipp Schenk, describing a new USP9X inhibitor with a unique DUB binding site.
We show that the E3 ubiquitin ligase DTX2 creates a dual hybrid ADP-ribosyl-ubiquitin mark (ADPr-Ub) at DNA damage sites, driving the recruitment of RNF114, RNF138, and RNF166 proteins independently of HPF1.
journals.plos.org/plosbiology/...
Abstract deadline extended to April 20 for the FASEB #UbiqSRC, colocated with the #ProtFoldSRC, June 1-4 in Louisville! Register for one of the ~20 talk slots throughout the main meeting and pre-meeting career forum!
events.faseb.org/event/Ubiqui...
The next chapter in ADP-ribosylation biology: modification of uracil and guanine bases by PARP10 and PARP15
www.biorxiv.org/content/10.6...
In this paper, we present the first evidence suggesting that reversible RNA ADP-ribosylation on bases occurs in higher organisms (through the combined action of PARP10 and TARG1):
academic.oup.com/nar/article/...
New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵
Registration now open! 2026 #EMBO #Ubiquitin Workshop set in stunning Monopoli, Puglia 🇮🇹
Cutting edge science, great speakers, short talk opportunities, travel awards
Limited spaces. Dont miss out - register early!
Registration & more info: meetings.embo.org/event/26-ubi...
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
Congratulations Jake @mediocre-jake.bsky.social, Bekky Feltham and team on their phenomenal effort in putting together the E3-ome, published in Cell www.cell.com/cell/fulltex....
An extremely valuable resource for ubiquitin researchers.
Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and @alessandrick.bsky.social together with our wonderful collaborators, the one and only Dagdas lab @plantophagy.bsky.social!
Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...
Receptor clustering is a common theme in viral detection, but whether detection directly hinders genome replication is less clear.
Excited to share the Z in RZ-type E3s: ZNFX1 is an RNA helicase that builds ubiquitin chains leading to aggregates that ensnare viral RNA.
www.cell.com/molecular-ce...
Excited to decode the intricate language of ubiquitin chains and unravel their role in protein degradation? 🧬🔬
👉 APPLY NOW to join the lab of Dr. Leo Kiss @leokiss.bsky.social @imprs-lm.bsky.social.
#CellularBiochemistry #Ubiquitin #Proteostasis #ProteinDegradation
Aspiring science communicators:
SCIENCE TALK '26 • Association of Science Communicators is happening in Portland next week!
If you don’t have time to attend the conference, but need a Friday evening activity, there will be a fun science cabaret show:
www.mcmenamins.com/events/27505...
It’s a bit late - but our work on Enhancement Targeting Chimeras (ENTACs) is out now! Check out our work describing how induced proximity of a DUB can stabilise short-lived receptor like CTLA4.
@livuni-ismib.bsky.social
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...
Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social
The longest-running UB/UBL conference, join @labjoazeiro.bsky.social and @sshaolab.bsky.social, for #UbiqSRC. Featuring keynotes by @idikic.bsky.social of @goetheuni.bsky.social with Jeff Kelly from @scripps.edu.bsky.social. Submit your abstract and register to join us in Louisville: buff.ly/uAY0w0M
When Salmonella typhimurium invades cells that line the intestine, it uses a syringe-like type III secretion system to inject dozens of proteins (effectors) into the host cell cytoplasm. This beautiful descriptive study provides the first chronology of the order in which the effectors are injected.
Check out this exciting joint Career Forum organized by and for scientists-in-training that will take place before the co-located FASEB Meetings on Ubiquitin and Protein Folding in the Cell, June 1-4, in Louisville, KY!
Register for either meeting to opt in. Abstract deadline April 6.
Excited to announce that FASEB Ignite Career Forum 2026 (preceding FASEB Ubiquitin Mechanisms, Functions, and Therapeutics & Protein Folding in the Cell) is open for registration! Abstract deadline - April 6, 2026
For more details -
events.faseb.org/event/Protei...
events.faseb.org/event/Ubiqui...
Very happy to see this out! Great work by @lockwop.bsky.social @crick.ac.uk and first paper on NTMs from the lab! Parise made a set of 12 fluorescently labelled NTMs covering environmental and opportunistic mycobacteria...
onlinelibrary.wiley.com/doi/10.1111/...
New Review in Trends in Cell Biology with @lumirare.com.
First integrative catalogue of 267 cullin-RING substrate receptors (93 linked to germline disorders) + programmatic-friendly Excel resource for the community.
www.cell.com/trends/cell-...
VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...
CBASS is a cyclic nucleotide-based antiviral system in bacteria that is related to cGAS-STING signaling in animals. One of the big questions is how CBASS is activated during phage infection? We made some progress on this during my final year in the Kranzusch lab.
www.biorxiv.org/content/10.6...
I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)
