📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️

biomed.news/bims-imicid/...

Lot's of exciting findings!

1) Purine salvage pathway protects CD8+ T cells from metabolic stress

2) Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy

Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies

portlandpress.com/biochemj/art...

🤔Do you think that OXPHOS in DCs = tolerance?
In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance.
Life (& #immunometabolism) is not simple ⚡️
OPEN: www.cell.com/cell-metabol...
#immunoSky

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

14 things our PhD supervisors got right and why it mattered PhD students reflect on how their supervisors made a meaningful difference — from quiet acts of kindness to career-shaping guidance.

In its 2025 PhD survey, Nature asked more than 3,700 doctoral candidates around the world a simple question: what is the best thing your supervisor has done for you during your studies? Nature highlights several moments when good supervision made the difference. #Academicsky 🧪

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

My students would be screwed with that clause given we work on macrophages 😅, however, it can be nuanced with "unless the data lead you to T cells"

Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award.

Prof. Yates: www.gairdner.org/winner/john-...
Prof. Aebersold: www.gairdner.org/winner/ruedi...
Prof. Mann: www.gairdner.org/winner/matth...

#2026GairdnerAwards

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting new 'immunometabolism' method:

Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS) causing psychomotor regression and...

Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease
www.medrxiv.org/content/10.1...

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Good Sunday, all! Don't miss this weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology, it contains wonderful discoveries. Check it here: biomed.news/bims-camemi/... Biomed News #keepreading

"You're only as free as your attention is."-Sam Harris

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting papers 🧪:

I) The immunometabolic topography of cellular organization in TB

II) The human antibacterial factor APOL3 couples lysosomal damage to mtDNA efflux and type I IFN induction.

STING–NF-κB signaling builds an influenza spillover barrier Influenza pandemics are often traced back to the spillover of avian influenza A viruses (IAVs) to humans. However, barriers against IAV transmission remain elusive. We demonstrated human stimulator of...

Increasing evidence that STING has functions beyond DNA viruses. A new study reports that STING restricts influenza infection, independently of IFN. This work complements prior studies that STING prevents infection with diverse RNA viruses.
www.science.org/doi/10.1126/...

Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and #immunometabolism in inflammatory macrophages 🧪
www.biorxiv.org/content/10.6...

Glutathione is critical for NK cell-mediated immunity Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-medi...

Glutathione is critical for NK cell-mediated immunity #immunometabolism www.cell.com/cell-reports...

@biomednews.bsky.social

Figure 9: Anti-influenza mechanism of action of cis-aco. DOI: 10.1038/s44321-026-00379-8.

📢Last weeks #immunometabolism discoveries 🧪@Bims_BiomedNews ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling #mitochondria #metabolites

Hi Erik, I just wanted to follow up on being included in the science feed? Thank you!

Hi Dani, I wrote to be included in the science feed some time ago but my science communication posts with all the requested information but they don't appear here yet. Would you mind adding me to the list? Thank you!

Graphical abstract from https://doi.org/10.1016/j.immuni.2026.01.003

Graphical abstract from https://doi.org/10.1016/j.molcel.2026.01.010

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ 🧪

biomed.news/bims-imicid/...

Incl.

I) Hormonal rewiring of immunity during DR ensures host defense & systemic glucose conservation

II) Asparagine sensing by TBK1 controls phase separation to drive antiviral innate immune resp.

The paradox of immune systems conservation between prokaryotes and eukaryotes - Nature Reviews Microbiology The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Arg...

Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity!

www.nature.com/articles/s41...

Lokiarchaeon CBASS ❤️

Good morning, all! Here is a beautiful selection of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"For everything you do, there will be a last time that you do it."-William B. Irvine

@biorxivpreprint.bsky.social RNP+Sm+ defines a high-risk, refractory, myeloid-driven lupus endotype characterised by activity linked hyperferritinemia that likely requires therapies directed at the underlying IFN and myeloid-centred pathways @ucl.ac.uk
www.biorxiv.org/content/10.6...

It's an incredible piece of work