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Posts by Jack Holcombe

This is awesome! Congrats! 🎉

4 days ago 1 0 1 0
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Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1

1 week ago 64 32 9 1
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Glad the BBC are prioritising the most important global stories on the front page this morning.

4 days ago 0 0 0 0
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Genetics reveal why people respond differently to GLP-1 weight-loss drugs Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these drugs vary and who might face adverse effects.

Why do people respond differently to GLP-1 weight-loss drugs? Genetics has the answer - provided in this genome wide association study led by @adamauton.bsky.social www.nature.com/articles/s41...
🧪

www.nature.com/articles/d41...

1 week ago 19 8 1 0
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MitoTracker transfers from astrocytes to neurons independently of mitochondria The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

Well thats awkward

www.cell.com/cell-reports...

1 month ago 3 0 0 0

Nice one Kev! Looking forward to seeing more content from the squishy bois

1 month ago 2 0 0 0
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Postdoctoral Research Associate at The University of Edinburgh Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

Like #hemocytes? I'm advertising a 3 year, BBSRC #postdoc position, in #Edinburgh, using #Drosophila & human cells to understand sex differences in the regulation of #macrophage function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.jobs.ac.uk/job/DQU604/p...

1 month ago 16 19 1 0
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Such a tease!

1 month ago 1 0 0 0
Netanyahu: ‘These So-Called Genocide Experts Have Probably Never Committed A Genocide In Their Lives’

Netanyahu: ‘These So-Called Genocide Experts Have Probably Never Committed A Genocide In Their Lives’

Netanyahu: ‘These So-Called Genocide Experts Have Probably Never Committed A Genocide In Their Lives’ theonion.com/netanyahu-these-so-calle...

1 month ago 2837 590 33 28

Hegseth has admitted that America has *no interest* in "fighting fair." And what it did to that warship near India was an obvious war crime; even the Nazis rescued drowning sailors. So one would have to be naive to say the US-IDF alliance "wouldn't" issue strategic drone strikes.

1 month ago 624 106 5 3
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Thirty-six solutions to stabilize Earth’s climate An updated visual assessment tool can bridge the gap between climate research and political action

Thirty-six solutions to stabilize Earth’s climate | Science www.science.org/doi/10.1126/... 🧪

1 month ago 44 22 1 0

Congrats!

1 month ago 1 0 0 0

My paper on how the fruit fly foregut uses a modified cell cycle to respond to tissue damage and cell loss is now published :)

www.nature.com/articles/s41... #proventriculus #drosophila

1 month ago 42 11 4 1
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'I didn't grow up wanting to be a politician, I'm a plumber'

The green Party's Hannah Spencer has won the Gorton and Denton, with Reform in second and Labour finished third

1 month ago 1697 350 73 85

Havent seen the sun in weeks Kevin, allow it this once 😂

1 month ago 1 0 0 0
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First bike to work without a coat this year! (Also whats that weird colour in the sky???)

1 month ago 3 0 1 0
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@rorylcooper.bsky.social 👀?

2 months ago 2 0 1 0

🙏

2 months ago 1 0 0 0

Never pee near scope, ends badly

2 months ago 1 0 1 0
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Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk

Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹

Full info below, and please share! 🫶🏻

bit.ly/467TO0M

2 months ago 34 22 0 1
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Have a look at our latest preprint, "Nuclear plasticity regulates macrophage phagocytic capacity in vivo".

#apoptoticbodies #efferocytosis #nucleus #Drosophila #macrophages #mechanoresponse #InVivo #LiveImaging

doi.org/10.64898/202...

2 months ago 4 3 2 0

Very cool, congrats!

2 months ago 1 0 1 0

Amazing city, even better lab!

3 months ago 1 0 0 0

Congrats! So Beautiful!!

4 months ago 0 0 0 0
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Aaand... my first cover!!

RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬

4 months ago 32 6 5 0
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🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬

This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!

www.findaphd.com/phds/project... 🧪

5 months ago 36 18 3 1

Lovely to see this, congrats @senapati.bsky.social !

5 months ago 1 0 0 0
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Visceral signaling of post-ingestive malaise directs memory updating in Drosophila Consolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor...

@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out.

www.biorxiv.org/content/10.1...

5 months ago 42 17 1 1
A painting of a very large hog.

A painting of a very large hog.

AWS is down, post hog

6 months ago 4634 1011 63 83
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These ancient bumblebees were found with their pollen source Insects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years.

Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby.

The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.

#Paleontology #NationalFossilDay

🧪🏺

New at @sciencenews.bsky.social

6 months ago 456 112 12 10