Happy to share our review of the past, recent, and future applications of synthetic genomics in studying the 3D functional organization of chromosomes, a set of approaches that are gaining momentum!
www.sciencedirect.com/science/arti...
Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!
Excited to share my PhD work!
The question: How is genome organization established? Here, we developed a low-input Micro-C method, Pico-C, and used it to map chromatin architecture across early stages of fly development.
Here’s a quick Blue-torial 🙂 (1/n)
www.nature.com/articles/s41...
We just published a short conceptual review together with @angela-taddei.bsky.social on the spatial controls of homology search in both bacteria and eukaryotes. We discuss an emerging framework for homology search in cells with two main phases. Check it out: authors.elsevier.com/c/1mjyh,LqAZ...
Congrats!
New paper alert from the group!! 🚨: DNA flexibility tips the balance between stability and plasticity in nucleosomes
One of the works from my PhD, co-led alongside @nachper.bsky.social, is finally out! Work from @rcollepardo.bsky.social & @janhuemar.bsky.social
⬇️
www.biorxiv.org/content/10.6...
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How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Interested in transcriptional regulation, enhancers and 3D genome folding?
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed 🧵👇
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...
Happy to share our perspective on the DNA translocation mechanism by the CMG helicase.
DNA translocation by the CMG helicase: the helical inchworm model url: portlandpress.com/biochemsoctr...
Yet another reason why butterflies and moths are so interesting! Unlike other studied organisms that organise their DNA into two forms of chromatin, silkworms have a mysterious third form of chromatin folding..
Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
We are hiring!
Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science
🚨 New preprint from the lab. Combining modeling and data analysis of SisterC data in yeast, we investigate cohesion of replicated chromosomes and show that sister chromatids are loosely and asymmetrically aligned in G2/M. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.6...
Not just yet…
We produce it ourselves and I know @jsoro.bsky.social does that too…
🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
Excited to share my PhD work from @riscalab.bsky.social on @biorxivpreprint.bsky.social CAD-C & CADwalks –repair-free, nucleosome-resolution chromosome conformation capture with engineered TEVp-activatable CAD. CADwalks: chromosome walks of ligated CAD footprints. doi.org/10.64898/202...
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Epigenetics Update - Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription go.nature.com/49iRJkK
Albert W. Cheng and Yijun Ruan (Jackson Laboratory) reporting in NSMB
#Epigenetics #Chromatin
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Discover the breakthrough at epigenometech.com
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
A thread on our latest paper from the Whitehouse lab
Hello everybody,
I am looking for an Engineer (IE) to help me start the lab at LBMC / ENS-Lyon in April.
We will investigate chromatin organization during replication in yeast.
RT appreciated!
To apply: inserm.softy.pro/offre/187863
@lbmcinlyon.bsky.social
#NewPI #3DGenome #chromatin #replication
Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
Happy to share our new review on 3D chromatin organisation by cohesin with you. It was a great pleasure to review recent advances and future prospects with @danielgerlich.bsky.social.
CAD-C: An engineered nuclease enables repair-free in situ proximity ligation and nucleosome-resolution chromosome walks in human cells www.biorxiv.org/content/10.64898/2025.12...
🚨Our work on the impact of DNA replication on 3D genome is out in Genome Biology: replication-dependent loop extrusion by sister-forks, wave of replication, no evidence for large-scale replication factory. Great collab with @aurelepiazza.bsky.social. More here: link.springer.com/article/10.1...
A thread on our latest paper from the Whitehouse lab