Coconuts

Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants - Nature Genetics Genome-wide analyses identify 13 loci associated with susceptibility to infection with SARS-CoV-2 Omicron variants, including variation in ST6GAL1, previously associated with influenza susceptibility,...

"We identified 13 genome-wide significant loci associated with SARS-CoV-2 infection. The strongest signal was a single nucleotide polymorphism in an intron of ST6GAL1 (...) connected to three other associated loci (harboring MUC1, MUC5AC and MUC16)" #glycotime 🧪

www.nature.com/articles/s41...

This is really nice

But Joao, aren’t you afraid of being scooped?

No.

It’s an ultra-rare childhood epilepsy. If you scoop me and the kids get help from it, I will help you scoop me and then move on.

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎

doi.org/10.1038/s420...

The Glycomics Core at Beth Israel Deaconess Medical Center is looking for a Postdoctoral Research Fellow with LC-MS/MS proteomics/glycoproteomics experience. For more information check: research.bidmc.org/ncfg/careers...

#proteomics #glycomics #glycoproteomics #lcms

#GGDB (GlycoGene) in #ACGG-DB is a database focusing on glycogenes within #GlyCosmos and provides key information—including substrate specificity—on glycosyltransferases and sulfotransferases to support glycosylation/glycan biosynthesis analysis across species #glycotime

OpenScholar OpenScholar’s specialized tools and built-in features enable you to create a website that maximizes impact while saving you time, money, and resources.

The fact that there is already an application out there called OpenScholar and they have a registered trademark and this tool uses the same name is worrying.

theopenscholar.com

This is amazing work! #glycotime

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...

Enzyme catalyzed bioorthogonal chemistry published at ACS Cent Sci

pubs.acs.org/doi/10.1021/...

Identification of an allosteric site on the E3 ligase adapter cereblon - Nature An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

Exciting new work from @thewoolab.bsky.social just out @nature.com

www.nature.com/articles/s41...

#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.

The rate of global sea level rise doubled during the past three decades - Communications Earth & Environment Global mean sea level rise amounted to 4.5 mm per year as a result of warming oceans and melting land ice, more than twice the rate of 2.1 mm/year observed at the start of satellite data in 1993, base...

The rate of global mean sea level rise has increased from ~2.1 mm/year in 1993 to ~4.5 mm/year in 2023. www.nature.com/articles/s43...

Structure of a protein (cyan/teal) rendered as surface with 50 frames representing the dynamic ensemble of the glycans (white surface and sticks) depicted at the three sites (N93, N99 and N104) indicated by the 2D SNFG symbols and corresponding GlyTouCan IDs. Graphic rendering with VMD

Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble.

In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,

Notice of Request for Information; Accelerating the American Scientific Enterprise The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...

OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy

www.federalregister.gov/documents/20...

Christmas wreath obtained by photoshop (gimp.org) of a protein structure with glycans in white rebuilt with Re-Glyco, protein in orange surface, red beads and green cartoons from PDB 8DLO

Happy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵

We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩

Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23...
#glycotime #glycosylation #science #artificialsweeteners

Gut mucin fucosylation dictates the entry of botulinum toxin complexes - Nature Communications Botulinum toxins vary in oral toxicity, but the reasons are unclear. Here, the authors show that the differences can be due to variations in one of the toxin’s components, the hemagglutinin complex, w...

Gut mucin fucosylation dictates the entry of botulinum toxin complexes www.nature.com/articles/s41...

For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]

Update and new implementation of the MIRAGE reporting guidelines for mass spectrometry experiments in glycoscience The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for mass spectrometry (MS) data were initially developed to standardize the reporting of instrumentation, data acquisiti...

Cannot hide my joy, relief, excitement being able to share the outcome of persevering (to say the least) collaborative work. So... the MS glyco(proteomics) guidelines are published!! www.mcponline.org/article/S153...
Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss

Meeting Report on the 1st GlyCosmos Symposium & Jamboree —Community-Driven Expansion of Glycan-Binding Molecules Resources Chiaki Nagai-Okatani, Masae Hosoda, Winnie Hsiung, Takashi Sato, Hiroaki Sakaue, Sayaka Fuseya, Eriko Fukuda, Issaku Yamada, Kiyoko F Aoki-Kinoshita, Atsus

We are excited to share our #glycotime meeting report on the 1st GlyCosmos Symposium & Jamboree in *Glycobiology*!
DOI: doi.org/10.1093/glyc...

Participants advanced glycan-binding molecule resources through hands-on work on lectin curation and FAIR glycoinformatics within #GlyCosmos.

It's finally here! serversideup/php v4 is now stable 🎉

😅 Over a year of work
🐘 FrankenPHP & Laravel Octane support
🤖 LLM integration on our docs
🤝 13 new contributors
❤️ All open source

Run PHP and Laravel anywhere you want.

Now go build awesome stuff, Internet. 🚀

Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.

1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis

2. Proteins are a source of glycans found in preparations of glycoRNA

Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!

The @nuxt.com team is highly underrated 💯

I'm working with Nuxt Content, and this product blows my mind 🤯

It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too.

You know you're crushing it when a SERVER GUY compliments JavaScript 🤓

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cance...

Sharing our recent pre-print where we drill down further into the transcriptional regulation of Siglec ligands. Here we show that tissue specific regulatory networks dictate changes in sialoglycan patterns. Work led by Rebecca Garnham and postdoc Adam Duxfield.

www.biorxiv.org/content/10.1...

Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide - Nature Communications Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...

Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺

"Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍

www.nature.com/articles/s41...

You're kidding me!? 👀

TIL about "post_start" in Docker Compose 🐳

You can run commands as a privileged user on startup, but still run your services as an unprivileged user.

This dramatically simplifies bootstrapping an app! 🤩

serversideup/php v4.0-beta1 is now available!!!

It's a next level Docker image:

🐘 FrankenPHP now available
❤️ Improved native health checks
🤖 Advanced Laravel automations
🤩 12 new contributors

Our biggest open source release yet. LET'S GO PHP!! 🚀