I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

📢 We are inviting you to the second session of the 2026 @cambridgeflyclub.bsky.social talks.

SPEx: Compartment-Resolved Proteomics via Expansion Microscopy-Guided Microdissection www.biorxiv.org/content/10.64898/2026.03...

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵

www.biorxiv.org/content/10.6...

An image montage advertising NeuroBioUK - 11th of September 2026 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Save the date for #NeuroBioUK26

Do you like neurons? Maybe glia? Molecules? Cell biology? - The venue is booked and we are excited to see you and your incredible science there on the 11th of September! Please do join our email list to stay up to date.

neurobiouk.sites.sheffield.ac.uk

The Golgi Network, Volume II This book explores the interaction of Golgi with different organelles such as ER, the vesicular system, and protein complexes that execute these tasks.

A wonderful collection of contemporary topics and perspectives on secretion and Golgi biology edited by Akihiko Nakano and Jaakko Saraste.
The Golgi Network, Volume II @SN and link.springer.com/book/10.1007...

📢✨A fantastic start to our 2026 programme at the @cambridgeflyclub.bsky.social!
This month, we held our first 2026 session of talks, with inspiring presentations, lively discussions, and a brilliant turnout.

An important study maps how nerves control the Drosophila male reproductive tract, revealing two types of glutamatergic neurons that also release serotonin or octopamine.

🔗 buff.ly/3PV2YQW

See you all at the Gurdon Institute! 🔔

The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...

#Trafficking

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy

Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies

portlandpress.com/biochemj/art...

✨ We are pleased to announce the conclusion of the final session of the 2025 @cambridgeflyclub.bsky.social talks series and are now preparing for next year’s sessions, which will be announced soon (check out our upcoming posts for more details).

The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A Newly-made secretory and membrane proteins exit the endoplasmic reticulum (ER) in COPII vesicles that form at specialised ER exit sites. These exit sites are typically near to the early Golgi compartm...

The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A www.biorxiv.org/content/10.1...

Fwd: Fwd: “I hope this email finds you well”

The advent of confocal laser scanning microscopy in biological research Nature Reviews Molecular Cell Biology, Published online: 01 October 2025; doi:10.1038/s41580-025-00905-5The advent of laser-scanning confocal microscopy revolutionized cell biology, offering unprecedented resolution and depth and enabling scientists to visualize cellular structures in 3D.

New Online! The advent of confocal laser scanning microscopy in biological research

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Membrane protein export in developing axons, via axonal ERES and Golgi bypass #ER_Literature

A Genome-wide CRISPR Screen Reveals ZDHHC8-Dependent Gαq Palmitoylation as a Key Regulator of GPCR Signaling G protein-coupled receptors (GPCRs) that couple to the Gαq signaling pathway control diverse physiological processes, yet the full complement of cellular regulators for this pathway remains unknown. H...

A Genome-wide CRISPR Screen Reveals ZDHHC8-Dependent Gαq Palmitoylation as a Key Regulator of GPCR Signaling
Muhammad Ahmad, Norbert Perrimon, Raghuvir Viswanatha, Ah-Ram Kim
bioRxiv 2025.08.06.668953; doi: doi.org/10.1101/2025...

Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of ...

New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch et al.
doi: doi.org/10.1101/2025...

fluorescence imaging of drosophila nerves

A new genetic toolkit lets researchers target most neuronal lineages in the #Drosophila ventral nerve cord across development and into adulthood, opening the door to mapping structure, chemistry, and behaviour.
buff.ly/zHQK9dC

Carmina Santa-Cruz Mateos from PDN, University of Cambridge: "Condensing the Message: How Notch Signaling Forms Transcriptional Hubs to Control Gene Activation" Jimena Berni from Medical Research Building, University of Sussex – “Hox Activity Levels Govern the Evolution of Behaviors” Expect refreshments and pizza, this is a great chance to meet colleagues, exchange ideas, and build collaborations. Spread the word, everyone is welcome!

🗓️#CambridgeFlyClub 2nd meeting this year on July 16th (Weds) 4pm at @gurdoninstitute.bsky.social. Our speakers are Carmina Santa-Cruz Mateos from Sarah Bray's lab @pdncambridge.bsky.social and Jimena Berni from University of Sussex.
It's not the Dmel on our poster, guess what species is it?

The mechanistic basis of cargo selection during Golgi maturation The multiple cisternae of the Golgi apparatus contain resident membrane proteins crucial for lipid and protein glycosylation. How Golgi residents remain in their designated compartments despite a cons...

The mechanistic basis of cargo selection during Golgi maturation www.biorxiv.org/content/10.1...

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Registration is now open for NeuroBioUK 2025!
This year we're looking forward to hearing from our plenary speaker @cathyabbott.bsky.social. As ever, all other talks chosen from submitted abstracts so get submitting - we can't wait to see you there!

neurobiouk.sites.sheffield.ac.uk/registration

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network | PNAS Maintenance of pH within membranous organelles is crucial for cellular processes such as posttranslational modifications, ligand–receptor interacti...

Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network | PNAS www.pnas.org/doi/10.1073/...

This is so bad :(

Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.

Journal of Cell Science Meeting 2026 Imaging Cell Dynamics Date: 11 – 14 May 2026 Venue: Montanyà Hotel, Catalonia, Spain Register your interest

After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social‬, @drmichaelway.bsky.social‬ & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...

Following the annual tradition, the student symposium of MRC LMB is happening on July 10th and 11th this year.

This year we are collaborating with Institut Pasteur!

Details 👇

Congratulations Maheva!