The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...
A large diverse group of people waving and smiling at the camera in front of scientific posters displayed on a wall.
That’s a wrap on our @embo.org #cryoFIB & #cryoET course!
It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.
An exciting PhD opportunity investigating ribosome hibernation in cancer is available in my lab, in collaboration with Steffen Scholpp and Ke Li! The interdisciplinary project will span cell biology, structural biology, and AI-guided modelling. Please get in touch if you are interested!
Male bald speaker in blue shirt giving a presentation on early days of tomographic imaging in the 1980s, featuring Walter Hoppe and technical diagrams.
Audience seated in a room attentively listening to a presentation, some holding notebooks or tablets.
Audience seated in a room attentively listening to a presentation, some holding notebooks or tablets.
Female researcher presenting colorful microscopic images at Max Planck Institute for Biophysics during the EMBO Practical Course on “In-situ structural biology by Cryo-FIB and Cryo-ET”.
We’ve kicked off our @embo.org Practical Course on #cryoFIB & #cryoET!
Participants from around the world are joining us this week for hands-on training, from lamella milling to tomogram reconstruction 🔬
I vote for new profile picture
napari needs your help! Has napari helped you make cool and groundbreaking discoveries? We'd love to highlight that in our docs. Please tell us about it! You can fill in this survey:
napari.typeform.com/to/vTCKeTKv
and/or, as ever, drop by our chat room or meetings:
napari.org/dev/community/
🙏
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.
#OpenSoftwareAcceleratesScience
Excited to share our new study:
rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...
Come visit our @mpibp.bsky.social booth at the @biophysicalsoc.bsky.social #bps2026 meeting in San Francisco!
We’re looking forward to chat about our research, PhD opportunities, and international career paths! 🥳 We’d love to connect and take your #cellfie! 🦠 Find us in booth 630! #imprs #imprs_cbp
Thank you for including some of our figures here. I thought the exact same and as it happens we did deposit a few (not all) ChimeraX sessions alongside the raw data and analysis code here (tree mode view is easier):
edmond.mpg.de/dataset.xhtm...
one of them including these disomes compared to others
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes pubmed.ncbi.nlm.nih.gov/41712727/ #cryoEM
Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...
Thank you Matt!
Ribosomes in pairs: A survival strategy inside stressed cells.
When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...
What a great example of collaborative science enabled by people sharing things early on. Well done @lifeonthewedge.bsky.social and others!
Likewise! will do :)
Hey Jeremy, it was great meeting you. I had a great time at SfN and the trip back flew by. Still impressed by the sheer magnitude of this conference and I learned a lot. How about you?
Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET!
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
I’m excited to share my PhD work on localized mRNAs and protein synthesis in cortical layer 1 on bioRxiv! www.biorxiv.org/content/10.1...
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....
😅 yeah.. we should catch up soon..
#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪
Thank you Ben! We're pushing a small update this coming week and then on to other modalities that I still owe writing up 😅
Thank you Reika. Let's see how molecular profiling of cryo-ET develops in the next years. More to come :)
Likewise! I have an 18 h journey back from Madagascar so I'm downloading it right now.
