Flexible ensheathment of axons enables myelination of complex CNS networks - Nature The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

Latest offering. How myelin ensheathes axons!

Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths.

Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social

Enjoy!
www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/

www.nature.com/articles/s41...

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

Microglia checkpoints promote healthy myelin aging
Our new paper is out in Nature Neuroscience @natneuro.nature.com

www.nature.com/articles/s41...
🧵1/3

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

From Myelin Damage to Immune Dysfunction: Unraveling the Aging Brain Aging is associated with progressive white matter degeneration, which impairs brain structure and function. Defects in myelinating glial cells, combined with chronic neuroinflammation, contr

Join us 10/30 for a Labroots webinar with Dr. Janos Groh: From Myelin Damage to Immune Dysfunction: Unravelling the Aging Brain. Hear how single-cell + spatial transcriptomics reveal glial–immune interactions driving neurodegeneration.

Register: hubs.ly/Q03N0rVJ0

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging

Also check out the 'Nodes of Ranvier'

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains.

Learn more: vizgen.com/study-publis...

#SpatialBiology

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...

Now published in the June issue @natneuro.nature.com
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!

Thanks so much Jonathan and Veronique. We really enjoyed reading your beautifully written News & Views.

Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment - Nature Neuroscience Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white matter pathology i...

See also this excellent News & Views from Jonathan Monteiro and Veronique Miron @mironlab.bsky.social.
www.nature.com/articles/s41...

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...

Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury Ge et al. report a maladaptive innate/adaptive immune axis in which CXCR6+CD8+ T cells, recruited by glycolytically reprogrammed microglia/macrophage-derived CXCL16 chemokines, play an important role ...

Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury: Neuron www.cell.com/neuron/fullt...

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

How does the brain repair myelin after injury?

We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...

Details below 👇

Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky

💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.

👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!

Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.

What is the role of oligodendrocytes and myelin in the pathophysiology of Alzheimer's disease? Really excited to see this review published in @natureneuro.bsky.social
www.nature.com/articles/s41...

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.

Thread below: (1/11)

White matter aging and its impact on brain function Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.

How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social
www.cell.com/neuron/fullt...

To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by Axel Guskjolen.
We hope you enjoy every single piece of it as much as we do!
www.cell.com/neuron/current

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

Congratulations, Robert!