Cytokine receptors do not get old, my friends!

Cytokine multimerization: when more is more and sometimes less Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

ICYMI: Cytokine multimerization: when more is more and sometimes less

Job alert! Denisse Leyton and I are hiring a full-time Postdoctoral Fellow position (up to December 2028) at The Australian National University.

Application deadline is 12 April 2026

jobs.anu.edu.au/jobs/postdoc...

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Seven colleagues standing side by side outdoors on a wooden deck with greenery and trees in the background.

From Kim Good-Jacobson and team, new data demonstrate a vital role for disruptor of telomeric silencing 1-like (DOT1L) during B-cell lymphopoiesis, marginal zone B-cell generation, and germinal center B-cell biology. Read this #EditorChoice article: https://ow.ly/Oa0750Yn56n

Good Sunday, all! Don't miss this weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology, it contains wonderful discoveries. Check it here: biomed.news/bims-camemi/... Biomed News #keepreading

"You're only as free as your attention is."-Sam Harris

🧵Antibiotic resistance is a public health crisis. But viruses called phages have been solving this problem for millennia. New research in @nature.com reveals how 3 different phages attack the same weak spot—a protein called MurJt—potentially leading to a new class of antibiotics.

Structure and mechanism of antiphage retron Eco2 Nature Structural & Molecular Biology - This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein...

1/6) Hot off the press @natsmb.nature.com 🔥! Jasnauskaite et al. reveal how the minimal bacterial retron Eco2 defends against #phage 🛡️. Phage nucleases trigger Eco2, which cuts RNA, shuts down protein production and stops phage replication 🦠🚫. #phagesky #immunity #microbiology #cryo-em rdcu.be/e4AyH

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex: Cell www.cell.com/cell/fulltex...

I’ve officially started my lab at Monash University! 🎉

We’re diving into #cellgrowth and #lysosome biology, through the lens of molecular #structure and mechanism.

I’m thrilled to say that PhD student scholarships are available—so please share widely and get in touch if you’re interested. 🤩

Resistance Infrastructure | No Mercy / No Malice I’ve struggled my whole life to discern the difference between being right vs. effective. Over the past decade, the U.S. has been on a slow burn to fascism. The best description I’ve seen of America’s...

Sharing screenshots of your canceled subscriptions inspires others to Resist and Unsubscribe.

📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...

The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.

uq.wd3.myworkdayjobs.com/en-GB/uqcare...

🌀 How do spirochete bacteria swim through thick fluids like champions?

We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!

@debnathghosal.bsky.social

🔗 doi.org/10.64898/202...

#StructuralBiology #CryoEM #Microbiology

I am delighted to report that our latest paper has now been published in Science Advances:
www.science.org/doi/10.1126/...
In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...

Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.

TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop www.biorxiv.org/content/10.64898/2026.01...

🤠

Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex #cryoEM

www.nature.com/articles/s41...

Black text on white background. Screenshot of ARC’s Network Message regarding delays to grant announcements because of new security arrangements.

⁉️The ARC has delayed outcomes of ALL grants 1–4 months & increased scheduled outcome windows from 2 weeks to 3 months!

This reverses 4 years of progress in providing greater certainty & ability to plan for researchers, their families & unis.

Their excuse? Security checks under new ARC legislation👇

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

You can find out more here: www.cell.com/cell/fulltex...

The latest research from our team is out in Cell @cp-cell.bsky.social! We used #cryo-EM, #imaging, #BRET, and #biosensors targeted to the lysosome to understand how the KICSTOR-GATOR1 complex turns off #mTORC1 in response to low levels of amino acids.

Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading

"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex pubmed.ncbi.nlm.nih.gov/41512879/ #cryoEM

The #ChlamyDataset is on the cover of @cp-molcell.bsky.social 🖼️🥰!

Read @lifeonthewedge.bsky.social's great thread🧵 for the inside scoop🍨 on all the #TeamTomo developments already made possible since these 1829 tomos hit EMPIAR 🧪 🧶🧬

For more, here's the old preprint thread:
bsky.app/profile/cell...

The study was an excellent collaboration between researchers across @monashuniversity.bsky.social and was funded by the NHMRC. Research was driven over many years by the hard work of first authors @luptoncj.bsky.social and @charlesbj.bsky.social and co-led with Tyler Chang and @drmlhalls.bsky.social

An incredibly challenging single particle cryo-EM structure. Capturing both the N and C termini was difficult enough, but the project required a major effort to resolve the full length protein structure to capture the overall architecture of the KICSTOR-GATOR1 complex.

Well worth it in the end!

Excited to share our latest research, out today in Cell (@cellpress.bsky.social)

Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.

Read the paper here: doi.org/10.1016/j.ce...

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.

Now online! Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex