Towards end-to-end automation of AI research - Nature An artificial intelligence system can produce research papers with minimal human involvement, even passing the first round of peer review for the workshop of a main machine learning conference.

Time to retire?
www.nature.com/articles/s41...
"We present The AI Scientist, which creates research ideas, writes code, runs experiments, plots and analyses data, writes the entire scientific manuscript, and performs its own peer review".

Tissue Regulatory T Cells FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field

www.annualreviews.org/content/jour...

These are not a ranking lists we should be topping...
royalsociety.org/-/media/poli...

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Nobel prize for Tregs!
www.nobelprize.org/prizes/medic...

Kristoffer H Johansen presenting a talk at the Dept of Pathology, University of Cambridge.

Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).

Inside Health - Exosomes: Is cosmetics' biggest trend a health risk? - BBC Sounds James finds out why there are fears over new skincare products, plus physio goes digital.

Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/...
(Spoiler alert: he does not approve).

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...

Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.

Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...

Lab info: www.oncology.ox.ac.uk/team/jie-yang

I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰

I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through pro…

New research article from the lab led by the amazing @amydashwood.bsky.social !

In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11

www.sciencedirect.com/science/arti...

Last few days to apply for this:

PM - 05/03/2025 - BBC Sounds Afternoon news and current affairs programme

Listen to Rahul talk about the study about 20 min into this programme: www.bbc.co.uk/sounds/play/...

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Aspirin: Scientists crack how painkiller might stop cancers from spreading The cheap painkiller seems to help the immune system detect and destroy cancers.

Excellent article by James Gallagher at the BBC summarising the study and its implications:
"Scientists crack how aspirin might stop cancers from spreading"
www.bbc.co.uk/news/article...

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis.
www.nature.com/articles/s41...

Cellular signals for health & disease A symposium marking the contributions of Len Stephens and Phillip Hawkins

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪

Latest Institute research with special guests ⤵️

www.eventbrite.co.uk/e/cellular-s...

Seems dystopian, but this is now reality. Promoting diversity, equality and inclusiveness has become a crime and they are threatened to report anyone engaged in such activities. Free speech no longer applies.

Welcome!

📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community!

Find out more about the position and apply: https://buff.ly/40m1udb

www.path.cam.ac.uk/news/profess...

Many congratulations to Prof Ashley Moffett on this honour!
This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.

A very rare position for an immunology professorship at Cambridge. Something to think about!

www.jobs.cam.ac.uk/job/49381/

I've added a PI3K starter pack.
Please help me populate it by replying to this post.
#PI3K #PTEN #AKT #mTOR #FOXO
go.bsky.app/7p2g5eN

A starter pack for PhD students and Postdocs in Immunology to connect 🔽

Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!

#ImmunoSky 🧪

go.bsky.app/RABVXY4

Really great talk!

🙋

It's what happens to mice if they don't have Foxp3+ Treg to keep the immune system in check. Unpleasant and lethal.