Light-inducible FLPase reconstitution enables temporal control of gene expression in Drosophila melanogaster
#Drosophila

CALS- Technician I- Molecular Biology and Genetics in Ithaca, New York, United States of America | Research & Instructional Support at Cornell University Apply for CALS- Technician I- Molecular Biology and Genetics job with Cornell University in Ithaca, New York, United States of America. Research & Instructional Support at Cornell University

plz repost 🙏 we are looking for a technician to start this summer/fall for 1-2 years to work with me at Cornell in the labs of @cedricfeschotte.bsky.social and Andy Clark, in collaboration with @corriemoreau.bsky.social on flies & termites 🪰🐜🧬🔬 Ithaca is gorges!

jobs.hr.cornell.edu/us/en/job/WD...

Wolbachia-mediated reduction in the glutamate receptor mGluR promotes female promiscuity and bacterial spread The mechanisms by which parasites mediate host behavioral changes remain largely unexplored. Warecki et al. describe a molecular mechanism for how the endosymbiont Wolbachia induces increased mating i...

Warecki, B., Vega, G., Fowler, S., Hartzog, G., Karr, T. L., Sullivan, W. (2025). Wolbachia-mediated reduction in the glutamate receptor mGluR promotes female promiscuity and bacterial spread Cell Rep, 44(5):115629 www.cell.com/cell-reports...

Summary of Artificial Development System Models

#DBfeature #DBreview

Engineering development: From the repressilator and toggle switch to synthetic developmental biology

by Margaret Saha et al
www.sciencedirect.com/science/arti...

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1

Large-scale endoplasmic reticulum membrane solidification spatially organizes proteins under thermal or metabolic stress www.biorxiv.org/content/10.64898/2026.04...

If you know a graduating undergraduate looking for the chance to spend 1-2 years in a lab before graduate school, we're hiring! Our lab explores morphogenesis, defining how the cell adhesion & cytoskeletal machinery work together to allow cells to change shape & move tarheels.live/peiferlab/ 1/n RT

A Drosophila wing imaginal disc expression nej/CBP-RNAi in the posterior compartment under control of en-GAL4. Loss of H3K27ac is visualized by IF (magenta) and the resulting cell cycle arrest is visualized by expression of the FUCCI reporter (green for G1 and yellow for G2).

#CellCycle progression is linkied to #HistoneModification dynamics, but how is this regulated in vivo? @classenlab.bsky.social &co show that levels of H3K27ac, H3K27me3 & H3K9me3 are tightly linked to cell cycle dynamics in the #Drosophila wing imaginal disc @plosbiology.org 🧪 plos.io/4bPkPbv

A series of buttons for different levels. The bottom level is labeled "Earth" and the top level is called "Space"

At Kennedy Space Center astronauts have to take elevators to the top of launch pad towers in order to enter their space capsules before lift off. This is the elevator panel at Pad 39A.

fantastic lineup of fly neuroscientists

Kamaldeep Singh @kamaldeepsingh.bsky.social, Krishanu Ray and colleagues dissect how neuronal insulin signalling regulates axonal transport of recycling endosomes and promotes synaptic remodelling of the Drosophila CNS.
journals.biologists.com/jcs/article/...

You just need more all caps and exclamation points!

Using #SingleMolecule imaging we find that TFs:

-boost co-transcriptional #ribosomal #RNA processing!

-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!

@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org

www.biorxiv.org/content/10.6...

RNA-binding proteins have recently emerged as crucial regulators of embryonic development and cellular differentiation. We hope that our review on the roles of the RNA-binding protein SRSF3 in these contexts is useful for the dev/cell biology and RNA fields!

www.sciencedirect.com/science/arti...

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social

We gave a worm brain control of a fly body and it walked

What did we learn? Nothing, other than deep reinforcement learning is effective

We call it the digital sphinx

www.biorxiv.org/content/10.6...

NIH grant cuts hit women, early-career scientists the hardest: analysis Last year’s funding cuts at the National Institutes of Health (NIH) disproportionately impacted women and early-career researchers, according to a | Last year’s funding cuts at the National Institutes...

Grant terminations had deep impacts on all early career scientists, running counter to Bhattacharya’s stated interest in supporting them.

The terminations disproportionately harmed early career women.
www.fiercebiotech.com/research/nih...

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of can...

finally out @vaibhavmahajan.bsky.social! advanced.onlinelibrary.wiley.com/doi/10.1002/...

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

Call for Letters of Inquiry: Exemplary Pathways to STEM Graduate Education | Alfred P. Sloan Foundation Our mission is to make the world a better place through the advancement of scientific knowledge.

New @sloanfoundation.bsky.social grants: Exemplary Pathways to STEM Graduate Education.

Up to $500,000 for orgs focused on helping remove obstacles for undergraduates who want to pursue advanced STEM degrees.

Deadline is June 1. Please share & apply if this is you! sloan.org/programs/hig...

NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...

Flaws…interesting. I think of it more as a perk 😅

How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔

Most models assume the random forces driving locus motion are independent in space

New preprint by
@janniharju.bsky.social: this assumption fails in living cells 🧵

www.biorxiv.org/content/10.6...

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

Oscillations, like radio waves, can encode multiple dimensions of information. @sonnenlab.bsky.social studies oscillation dynamics in different stages of development. In the early embryo, Hes1 gene oscillations are predictors of cell fate. #gfe2026

Read a recent @dev-journal.bsky.social article⤵

I want this.

Enhancer-gene specificity in development and disease Summary: This Review discusses recent insights into the factors controlling enhancer specificity and how this might help us understand the genetic basis of human disease.

Enhancers are genetic regions that promote the activation of neighbouring genes. @radaiglesiaslab.bsky.social asks how long-range enhancers maintain specificity by constructing synthetic gene landscapes and exploring how they affect gene activity. #gfe2026

Alvaro's @dev-journal.bsky.social Review⤵

Ambient RNA & barcode swapping is a serious issue in single-cell genomics. Tools such as CellBender, scAR, DecontX & SoupX. We have developed CellSweep which is faster (in some cases by a lot) and much more accurate. Extensively tested and benchmarked. www.biorxiv.org/content/10.6... 1/

Dpn, Ase, Brat, aPKC

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Reporting not only on ROS accumulation with age (measured by cysteine oxidation) but remarkably acidification of very tightly controlled pH of the hemolymph (might be a general but overlooked aspect of aging including in humans). A really cool result! See preprint: www.biorxiv.org/content/10.1...

Tragic. Please pass this along to US Chairs and Deans, and consider it when you sit on promotion committees. This, combined with the review backlog, is dire - especially for our early career researchers.