It’s really too bad Twitter got rid of 3rd party app API’s. It would’ve free to have an app that has feeds from both BlueSky and Twitter/X

In honor of attendance at #EULAR2025 I watched “Vicky Christina Barcelona” on my flight. Plot is a mess but the locale is 🧑‍🍳 😚 Stop me in the hallway if you see me wandering around!

Arc Institute’s new AI can read and write the code of life Training on the DNA of nearly 130,000 species taught Evo 2 how to generate DNA sequences the same way other AIs do text or images.

www.freethink.com/biotech/evo-.... —new Al in medicine term to learn: “Generative Biology”. Evo 2, an Al trained on DNA of more than 100,000 species is able to spot patterns in genes across species, identify disease-causing mutations
, and even write brand new genomes up to 1 million base pairs long

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

"In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet 'agency priorities'"

www.nature.com/articles/d41...

CDC invites back about 180 fired employees, including some who help fight outbreaks The CDC is inviting about 180 employees back to work, about two weeks after laying them off.

CDC invites back about 180 fired employees, including some who help fight outbreaks
The employees were laid off about two weeks ago

US science is under threat ― now scientists are fighting back Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists.

Researchers are organizing protests and making their voices heard as Trump officials slash funding and lay off federal scientists

https://go.nature.com/4koFGpq

The College notes with sadness the death of legendary gastroenterologist Dr. John Fordtran at age 93 on February 23rd

Among his contributions to GI was the development of bowel preparation for colonoscopy

#GastroSky

issuu.com/amcollegegas...

Living Drugs for the Skin, and Beyond In the lab, Aimee Payne, Columbia’s new chair of dermatology, is transforming cells into living drugs for autoimmune diseases of the skin.

I’m encouraged by the so-far-so-good results of #CAR-T cells in human clinical trials for autoimmune diseases! Side note: If you’re interested in a clever twist of CAR-T, called “CAART,” that could reduce global immunosuppression, check out Dr. Aimee Payne’s work @columbiauniversity.bsky.social

Trump administration layoffs set to hit NIH are ‘devastating,’ former director Monica Bertagnolli says Sweeping layoffs are set to hit federal health and science agencies, including at the NIH, and former director Monica Bertagnolli called the situation at the NIH “devastating.”

Sat down with former NIH director Monica Bertagnolli yesterday at #aaasmtg to talk about layoffs set to hit the NIH and other agencies

“We’re going to lose the next generation, that is the most difficult loss," she said, adding she got very little sleep Friday 🧪

www.statnews.com/2025/02/16/n...

Ferrari cars are often red. A red car is a Ferrari.

Wrong? Then why claim this without functional antigen-specif data:

Exhausted T cells often express PD-1. A T cell expressing PD-1 is exhausted.

It is similarly incorrect. PD'1 and other markers are also expressed on activated and memory T cells.

If are shocked or outraged by this but you haven’t already found ways to channel that, here’s a small starting place - bsky.app/profile/ucsu...

Your first step doesn’t need to be big or perfect, it just has to happen. Take it, and then we can figure out the next one.

Insufficient sample size or insufficient attention to marginalized populations? A practical guide to moving observational research forward Naomi Harada Thyden; Insufficient sample size or insufficient attention to marginalized populations? A practical guide to moving observational research for

Are you interested in analyzing small samples from marginalized communities and aren't sure how?

My new commentary in AJE's collection on Methods in Social Epidemiology lays out rec's for researchers, public health practitioners, and data owners.

DM your email address if you need access.

The Physicians Really Are Healing Themselves, With Ozempic (Gift Article) At cardiology conferences and diabetes meetings, doctors can’t help noticing that thin seems to be very in.

Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/02/10/h...

#medsky

Volume 64 Issue 1 | Rheumatology | Oxford Academic The official journal of the British Society for Rheumatology. Publishes high-quality scientific (basic and translational) and clinical-epidemiological papers on a wide range of paediatric and adult rh...

The January issue of the journal #Rheumatology is now online. This month includes:

1️⃣ The BAD-BSR Behcet's living guideline
1️⃣ Star Trek quote 👀
4️⃣ Systematic reviews on FMF, Still's, MAS & ILD
7️⃣ Graphical abstracts

Plus, the brand new 2025 cover 😍

academic.oup.com/rheumatology...

Good summary of Lipoprotein(a). The next frontier of ASCVD risk/event reduction. Really interesting to see the intersection of Cardiology, Rheumatology, and Hematology. #CardioMetabolic #RheumSky #CardioSky #HemeSky

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells Abstract. CD8+ T cells contribute to immune responses by producing cytokines when their T-cell receptors (TCRs) recognise peptide antigens on major-histoco

⚠️ Cytokine Release Syndrome is a serious side effect of #CAR-T cell therapies. This article examines the pathways driving cytokine production in T cells during #immunotherapy: 🔗 doi.org/10.1093/imma... (6/8)

#CAR-T cell therapies, a timeline
#RWCS2025
Dr. A. Postolova

Really promising case series n=6 #SScl pts undergoing CD19 targeting #CAR-T cell therapy.⬇️ mRRS, ⬇️ digital ulcers, ⬇️ Raynaud’s attacks and pain, ⬆️ FVC, ⬇️ Scl70 Ab. Minimal cases of cytokine release syndrome and no reported immune effector cell-associated neurotoxicity syndrome #RheumSky

Good review article on the few studies published using #CAR-T cell therapy in SScl. Quick and free read

🌊 Proud to share our new paper showing how during a historic 2022 drought in n. Kenya chronic #stress (via nail cortisol) & high levels of #waterinsecurity were assoc. with ⬆️ levels of inflammation. Climate change negatively affects human health & biology. onlinelibrary.wiley.com/doi/10.1002/...

A: hs-CRP. Covariable-adjusted hazard ratios for the primary end point in comparison of the top with the bottom quintile were 1.70 (95% confidence interval [CI], 1.52 to 1.90) for high-sensitivity CRP, 1.36 (95% CI, 1.23 to 1.52) for LDL cholesterol, & 1.33 (95% CI, 1.21 to 1.47) for lipoprotein(a).

Finally a minimum of 5 trials of orflorglipron reading out in 2025 with the first trial to readout in April or May. As noted it's an oral GLP-1 non peptide drug. It's easily mass produced, requires no special dosing or refrigeration. Lilly expects worldwide launch January 2026 for obesity & DM2

Very pleased to confirm that my research investigating racism and Islamophobia discourses around cardiometabolic disease will be presented at the World Critical Dietetics Conference on the 14th Feb 💞

Tickets can be found at the WCD website: worldcriticaldietetics.org

Worth reposting this and highlighting the monumental work of @fackelmeister.bsky.social and colleagues. #CardioMetabolic #GastroSky #RheumSky #microbiome #plantbased

A Clockwork Ozempic? > AddictionNews A dialogue between MSNBC anchor Chris Hayes and Nicholas Reville on using GLP1-RA drugs to treat addiction.

A dialogue between Chris Hayes and Nicholas Reville on using GLP1-RA drugs to treat addiction. Another exclusive from @addictionnews.bsky.social.

Great illustration from this paper on the tissue distribution of #GLP1 and #GIP receptors and biologic actions. You have my permission to roll your eyes or bang your head on the desk every time a financial analyst refers to these as “obesity meds”. #CardioMetabolic pubmed.ncbi.nlm.nih.gov/37195250/

FLOW study in @nejm.org. MOA for renal protection with SEM likely multi factorial but independent of weight/glycemic control. #GLP1 RA’s reduce glomerular inflammation (⬇️ IL6), reduce fibrosis (⬇️ TGFb), & reduce vascular oxidative stress (⬆️NO, ⬇️ RAS). #RheumSky #NephSky #CardioMetabolic

Ozempic Receives New Indications in Chronic Kidney Disease Semaglutide is now approved for reducing the risk for worsening kidney disease and cardiovascular death in adults with chronic kidney disease.

www.medscape.com/viewarticle/...

For any other rheumatologists digging through all the #CAR-T papers, AAV in this case is for Adeno-Associated Viral/Virus. Not to be confused with ANCA-Associated Vasculitis. #RheumSky