An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice - npj Metabolic Health and Disease npj Metabolic Health and Disease - An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪

buff.ly/GDBusEN

#Respirometry #Metabolism #CVD #HFD

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice Chronic elevations in interleukin-6 (IL6) signaling have been shown to exacerbate features of cardiometabolic disease. A common variant in the IL6 promoter (location -174 G/C, identifier rs1800795) is...

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Sable Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795.

buff.ly/GDBusEN

#Respirometry #Metabolism #Inflammation #Adipose #CVD #HFD

Ambrosia Biosciences Secures $100 Million in Oversubscribed Series B Round to Fuel Cardiometabolic Research Ambrosia Biosciences has completed a $100 million oversubscribed Series B financing to advance its innovative cardiometabolic therapies into clinical trials.

Ambrosia Biosciences Secures $100 Million in Oversubscribed Series B Round to Fuel Cardiometabolic Research #United_States #Boulder #cardiometabolic #Series_B_Financing #Ambrosia_Biosciences

Long-Term Cardiometabolic Outcomes in Children With Obesity This cohort study evaluates if metabolically healthy obesity in children is associated with increased long-term cardiometabolic outcomes.

Reducción IMC asoc c/reducción riesgo de HTA, diabetes tipo 2 y dislipidemia en niños obesos saludables y no saludables, saludables tienen mayor riesgo de enf cardiometabólica q pob gral,deben recibir también TTO para obesidad #obesity #cardiometabolic #children jamanetwork.com/journals/jam...

Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study In this metabolomics study, Yulu Zheng and colleagues investigate associations between microbial metabolites and coronary heart disease, performing discovery and validation analyses using five differe...

Growing evidence links gut #microbiota to human #cardiometabolic health. In this metabolomics study, Yulu Zheng & colleagues investigate associations between microbial metabolites and coronary heart disease, performing discovery and validation analyses using five different cohorts 🧪
plos.io/4sS1TzG

Two graphs compare significant fibrosis in overall & steatosis populations, plotting odds ratio (OR) with 95% confidence intervals. X-axis shows CMRF risk factors: Obesity, High WC, HTN, GI, HTG, Low HDL, CMRF@2. Men & Women are represented in blue and orange. P values shown.

Among US adults, women with central adiposity, glucose intolerance, or ≥2 #Cardiometabolic risk factors had a greater increase in odds of significant #LiverFibrosis compared with men.

ja.ma/3MWLL0F

As a medical school professor, I remind students: weight-loss drugs aren't just "appetite meds." They're metabolic signaling.

A new proof-of-con...
#obesity #GLP1 #metabolichealth #insulinresistance #cardiometabolic
www.thelancet.com/journals/eclinm/article/...

Multidimensional Sleep Characteristics and #Cardiometabolic Comorbidity in Adults at Elevated Risk of Stroke Date Submitted: Jan 31, 2026. Open Peer Review Period: Feb 10, 2026 - Apr 7, 2026.

Reminder>> Multidimensional Sleep Characteristics and #Cardiometabolic Comorbidity in Adults at Elevated Risk of Stroke (preprint) #openscience #PeerReviewMe #PlanP

Cessation of weight management medications is followed by weight gain AND CARDIOMETABOLIC MARKER DETERIORATION!

I have been very vocal about this: I am angry that my #HealthInsurance #LACARE has denied me access to coverage b/c I am not morbidly obese. GLP-1’s do much more than cause weight loss! Here is proof that #cardiometabolic markers deteriorate when medication is stopped. #theydonotcareforyou

Multidimensional Sleep Characteristics and #Cardiometabolic Comorbidity in Adults at Elevated Risk of Stroke Date Submitted: Jan 31, 2026. Open Peer Review Period: Feb 10, 2026 - Apr 7, 2026.

Multidimensional Sleep Characteristics and #Cardiometabolic Comorbidity in Adults at Elevated Risk of Stroke (preprint) #openscience #PeerReviewMe #PlanP

New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their ATVB review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
www.ahajournals.org/doi/10.1161/...

MASLD coexisting with PCOS increases cardiometabolic risk AbstractBackground and Aims. In women in their reproductive years, metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary sy

Síndrome de ovario poliquístico con hepatopatía esteatósica asociada a la disfunción metabólica aumentan la probabilidad de obesidad, resistencia a la insulina y fenotipo cardiometabólico adverso durante la edad adulta #MASLD #PCOS #cardiometabolic academic.oup.com/jcem/article...

New data from the CURES Registry-2 show that cardiometabolic multimorbidity worsens short-term outcomes in pulmonary embolism, highlighting the impact of combined risk burdens on prognosis and care.
🔗 https://ow.ly/m36M50Y7HRO

#PulmonaryEmbolism #CardioMetabolic #CURESRegistry #CardioSky #MedSky

Insilico Medicine and Qilu Pharmaceutical team up to fast-track AI-designed drugs tackling heart, metabolism and aging-related diseases.

longevity.technology/news/120m-pa...

#AIinBiotech #Cardiometabolic #InsilicoMedicine #QiluPharma #PrecisionTherapy #longevity #HealthTech #DrugDiscovery

In a prespecified secondary analysis of the SURMOUNT-OSA trial it was found that #tirzepatide improves #cardiometabolic outcomes in patients with moderate-to-severe OSA and #obesity.
https://www.nature.com/articles/s41591-025-04071-1

More liberal use of bilateral adrenalectomy for bilateral adrenal tumours with cortisol excess Bilateral adrenal tumours with cortisol hypersecretion represent a common clinical challenge. Adrenal incidentalomas are detected in approximately 4% of abdominal imaging studies, with prevalence incr...

Quan-Yang Duh & Michelle B Mulder comment on:
More liberal use of bilateral #adrenalectomy for bilateral #adrenal #tumours with #cortisol excess thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises

#MedSky #EndoSky #OncSky

Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study Although mortality and cardiovascular event rates were similar across treatments, surgery led to better biochemical control and more favourable comorbidity outcomes.

New—Effect of surgical versus conservative management on #cardiovascular outcomes in patients with #bilateral #adrenal #tumours and #cortisol excess: an international, retrospective cohort study thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises

#MedSky #EndoSky

A novel imaging tool paired with a diabetes drug sharply cuts heart risk, pointing to a longer life for patients with diabetes.

longevity.technology/news/better-...

#longevity #diabetes #hearthealth #cardiometabolic #cardiovascularhealth #medicalimaging #preventivemedicine #healthspan

In a prespecified secondary analysis of the SURMOUNT-OSA trial it was found that #tirzepatide improves #cardiometabolic outcomes in patients with moderate-to-severe OSA and #obesity.
https://www.nature.com/articles/s41591-025-04071-1

Health Canada approves Rybelsus, the first oral GLP-1 pill to lower cardiovascular risk in adults with Type 2 diabetes.

longevity.technology/news/canada-...

#longevity #GLP1 #diabetes #cardiometabolic #hearthealth #metabolichealth #obesitycare #digitalhealth #biotechnews

Cardiometabolic & Preventive Cardiology — Evidence Synthesis Support
Client slots are limited.
Contact: WA: +201062827579
#Cardiology #Cardiometabolic #PublicationCraft #SystematicReview #MetaAnalysis #Network #research #mentor

MetaVia Inc. Successfully Meets Nasdaq's Minimum Price Requirements Again MetaVia Inc. has announced that it has regained compliance with Nasdaq's minimum bid price requirement, essential for maintaining its listing on the exchange.

MetaVia Inc. Successfully Meets Nasdaq's Minimum Price Requirements Again #USA #NASDAQ #Cambridge #MetaVia #cardiometabolic

AHA Targets Ultra-Processed Foods and Cardiometabolic Health in Science Advisory A science advisory has been published by the AHA regarding the association between ultra-processed foods and cardiometabolic health.

A science advisory regarding the association between ultra-processed foods and #cardiometabolic health has been published by the @AHA.

Read More: https://bit.ly/43ZBHJj

Orforglipron Reduces Body Weight, A1C in Adults With Obesity and T2D Topline data were announced from a phase 3 trial evaluating orforglipron, an oral GLP-1 receptor agonist, in adults with obesity or overweight and T2D.

Improvements in #cardiometabolic risk factors were also seen in patients treated with #orforglipron.

Read More: https://bit.ly/3LtyKum

I woke up and it did not disappear!

I am so deeply thankful to my mentors and colleagues for their guidance. Special thanks to @karalmarshall.bsky.social for believing in my offshoot data and supporting it.

#Neuroscience #Cardiometabolic #Health #AHAPreDoctoralAward #EatSleepRun

Cirius Therapeutics to Present Innovative Data on CIR-0602K at CVCT Forum 2025 Cirius Therapeutics reveals compelling results on CIR-0602K's cardiometabolic benefits at CVCT Forum 2025, showcasing innovative therapies.

Cirius Therapeutics to Present Innovative Data on CIR-0602K at CVCT Forum 2025 #USA #Washington #Cirius_Therapeutics #cardiometabolic #CIR-0602K

New article to read! Metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk factors, and cardiac manifestations in psoriasis.

🔗 doi.org/10.1111/joim.70053

#MASLD #Cardiometabolic #psoriasis

Overview of the analyses. Top panel: Latent dimensions were searched using RCCA, linking cortical thickness and gray matter volume measures (parcel-wise across the whole brain cortex) with a wide set of risk factors for non-communicable diseases. Bottom panel: In order to interpret the latent dimension, the brain loadings were compared with several brain features. Created in BioRender.

#BrainHealth & physical health should be studied together: Multivariate study of #UKBioBank by @sarahgenon.bsky.social &co uncovers links between #cardiometabolic health, physical robustness, #brain structure & #neurotransmitter systems @plosbiology.org 🧪 plos.io/48j0UQg

Why click: definitions (regularity vs timing), practical targets, and which behaviors show the strongest associations.
#circadian #cardiometabolic