Thank you, Sophie and Yannick. I hope you're doing well!

Thanks Elias, hope you’re doing well!

Without you I wouldn't be here. We study #myelin; I look forward to the years ahead!

I'd like to take this opportunity – being a group leader at @mpi-nat.bsky.social since this month – to thank the anonymous reviewers, the institute’s management, my fantastic team past and present, and the many wonderful colleagues with whom I've had and continue to have the privilege of working.

My congratulations, have a good start!

New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social

Huge team effort, with immense contributions by friends from nearby and around the globe.

www.science.org/doi/10.1126/...

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed

onlinelibrary.wiley.com/doi/10.1002/...

This nice paper adds cows to the list of species using tools

Well, it’s also good news for the community. My congratulations!

Looking forward to reading this. My congratulations, Noa and the entire team!

Long overdue…. My congratulations!

Looks like a very nice place for thinking about or discussing our projects...

If you’re interested in #neurodevelopmental disorders, or the transcriptional network regulating #myelin, or both, check this out. Congratulations Gilad and @barakboaz.bsky.social. I’m happy that we were able to contribute a tiny bit!

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!

www.biorxiv.org/content/10.1...

My congratulations; I'm certain the project will be a success

Oh, me too

During the symposium @amsterdamleuko.bsky.social, I learned that lifespan and quality of life have improved because caregivers now know better how to support #leukodystrophy patients. If that’s not a cause worth spending a scientific career on, I don’t know what is. Congratulations, Marjo!

Leukodystrophies are rare, severe brain disorders. It’s remarkable how much the field has progressed, from identifying disease genes and understanding some of the disease mechanisms to therapy, quite a bit of that owing to Marjos work @amsterdamleuko.bsky.social

Yesterday in Amsterdam, Marjo van der Knaap gave her retirement lecture at @vuamsterdam.bsky.social. An international group of scientists working on #leukodystrophies paid respect to her achievements, including by wearing the traditional gown. There was also a good party @amsterdamleuko.bsky.social

It’s years since I did #leukodystrophy research, so I’m looking forward to the updates I'll get in the next 2 days symposium @amsterdamleuko.bsky.social. We‘ll also celebrate the achievements of Marjo van der Knaap, who will retire soon.

Leaving Edinburgh and the peripheral nerve society meeting with lots of impressions of how much the science in this field has advanced in the last few years, and how basic science ultimately results in therapy approaches for neuropathies. Takes years but is very much worth it.

2025 PNS Annual Meeting - pnsociety.com

I‘m looking forward to the next days when I’m in Edinburgh to learn about the newest research on the peripheral nervous system at pnsociety.com/2025-pns-ann...

If you're interested in new tools for #myelin research, here come anti-CNP #nanobodies. Congratulations to Petri Kursula, Felipe Opazo and the entire team! For structural, cell biology, and imaging data see
www.biorxiv.org/content/10.1101/2024.05.25.595513v1

This interesting paper establishes zebrafish as a model to assess diameters of myelinated axons and their relevance for the speed of nerve conduction. Great work from Dave Lyons and his team in Edinburgh

www.nature.com/articles/s41...

This Thursday, interesting talk in the Forum Wissen in Göttingen

If you're looking for a current, practical overview about fluorescent imaging at very high resolution, here it is

www.sciencedirect.com/science/article/pii/S0962892423002398?via%3Dihub

If you’re interested in #axon/#glia interaction and #myelin, have a look at this interesting paper. My congratulations Zoe and Aiman to this great work. I’m glad that we were able to contribute a tiny bit

www.nature.com/articles/s41...