🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery.
🔗Find the paper here: doi.org/10.1242/jcs....
Exciting job offer: PhD Program Manager. Lead recruitment, support PhD candidates, and shape doctoral training at a top international life sciences campus. https://ow.ly/3YkN50YAuGM
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
In this Perspective, North, @doroteaartscience.bsky.social, Shoemaker et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
Rearrangement of amphipathic helices enables lipid uptake at ATG2A N-terminus.
📢 New #preprint from CRN Team Hurley!
The team uncovers the mechanism of ATG2A-mediated lipid transport 🧬
Structural modeling and simulations show that N-terminal helices gate lipid transfer, and a designed mutant transfers lipids three times faster in vitro.
🔗 bit.ly/4rHuWpr
Rearrangement of amphipathic helices enables lipid uptake at ATG2A N-terminus.
📢 New #preprint from CRN Team Hurley!
The team uncovers the mechanism of ATG2A-mediated lipid transport 🧪
Structural modeling and simulations show that N-terminal helices gate lipid transfer, and a designed mutant transfers lipids three times faster in vitro.
🔗 bit.ly/3ZVAxw6
Really happy to see this one out: www.sciencedirect.com/science/arti... Alibek's drive & great coll w/ friends @gekaragoz.bsky.social & E. Hallacli resulted in a cool story that starts with our beloved #Marchantia and ends with iPSC-derived neurons 🤩🤪 A short 🧵
Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
The compositional analysis of membranes in bulk cellular volumes via AIVE. (A–D)
CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪
🔗 Read the #publication: bit.ly/4qeZiOY
The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair
Dale Corkery, Yao-Wen Wu et al
link.springer.com/article/10.1...
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!
There are a couple of empty chairs at our table — want to sit with us?
Reach out to me or any lab member www.oeaw.ac.at/gmi/research... We’ll be hiring two postdocs in 2026.
We’re excited about ambitious and creative ideas and are committed to supporting future group leaders 1/2
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
Join us later today 👇
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease.
🔗 kurzlinks.de/50j8
Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!
Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Just one more week left to get an application in! Starting my lab at the Perutz and the @viennabiocenter.bsky.social has been a fantastic opportunity that shaped me as a scientist!
