Follow-up results from a phase 1 #clinicaltrial show that nearly 90% of people whose immune systems responded to the vaccine were still alive up to 6 yrs after receiving the last treatment. The 5 year survival rate for #pancreaticcancer is around 13%. @mskcancercenter.bsky.social

#cancerresearch

This is what I’m currently looking at @bsky.app

BRCA gene mutations now implicated in thyroid, bladder, skin, and head and neck cancer An international group have discovered associations between pathogenic variants of the BRCA 1 and 2 genes and four types of cancer. Published in ESMO Open, the findings expand the potential for p...

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered associations between pathogenic variants of the #BRCA genes & 4 types of cancer.

#hereditarycancer #genetics #cancerresearch #medsky

Molecular Diagnostics -- How Gene Tests Can Help Guide Your Breast Cancer Treatment Plan You want the most effective treatment for your breast cancer. Learn how molecular diagnostics can guide your doctors toward a treatment that works best for your tumor.

These tests give your doctor a “molecular fingerprint” of your #breastcancer, helping them not only tailor your treatment but also understand how the cancer is behaving in your body. @webmd.com

#bcsm #precisionmedicine

My beautiful beautiful boy 🎶 is 3 years old today. Happy birthday Leo! 🎂 🦴 🐕‍🦺 🐾 🎾

Frontiers | Testing for hereditary cancer genes in men: a missed opportunity for cancer prevention IntroductionGenetic testing for inherited cancer risk syndromes can inform targeted surveillance and intervention, but testing for male patients is inadequat...

Men represented a minority in #genetictesting for #hereditarycancer but had ⬆️ test + rates. These findings underscore the need for ⬆️ integration of routine screening for cancer risk factors in primary care settings to enhance early detection & prevention.

#menshealth #BRCA #medsky #cancerresearch

Surgical Outcomes After Risk-Reducing Mastectomy Among BRCA1 and BRCA2 Carriers This cohort study analyzes cancer risk and surgical complications after risk-reducing mastectomy for BRCA1 and BRCA2 carriers.

In this cohort study of 1208 women with a gPV in #BRCA the risk of developing #breastcancer or early major surgical complications after RRM was very ⬇️. The low occurrence of primary BC precluded meaningful statistical comparisons between different RRM techniques.

#bcsm

@jamanetworkopen.com

No Survival Advantage for Risk-Reducing Mastectomy Over Surveillance in BRCA1/2 Carriers | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways Study finds risk-reducing mastectomy in BRCA1/2 carriers significantly cuts cancer risk but offers no overall survival benefit over intensive surveillance.

UK Study finds risk-reducing mastectomy in #BRCA carriers significantly cuts #breastcancer risk but offers no overall survival benefit over intensive surveillance. @targetedonc.bsky.social

#hereditarycancer #bcsm #womenshealth #genetics #cancerresearch #medsky

Genetic variants involved in rapid immune response linked to earlier breast cancer onset in BRCA1 carriers Damaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast cancer onset in carriers of the harmful BRCA1 genetic mutation, reveal preli...

Damaging missense variants in innate immunity genes are associated with earlier age of #breastcancer onset in #BRCA1 185delAG carriers.

#hereditarycancer #bcsm #cancerresearch #genetics #womenshealth

Via @medicalxpress.com

Association between type and location of germline BRCA1/2 pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with breast cancer: results from an international coho... The clinical implications of specific pathogenic and likely pathogenic variant (LP/PV) types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.

Association between type and location of germline #BRCA pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with #breastcancer: Results from an international cohort study.

#bcsm #hereditarycancer #womenshealth #genetics #cancerresearch

Menopause, Menarche Impact Breast Cancer Risk in BRCA Carriers In a compelling advance for cancer genetics and epidemiology, a groundbreaking study has been published exploring the interplay between natural reproductive milestones and breast cancer risk among

Natural menopause, menarche and #breastcancer risk in #BRCA pathogenic variant carriers: A Mendelian randomization analysis by UK researchers.

#hereditarycancer #bcsm #medsky #womenshealth #genetics

Amy Byer Shainman Amy Byer Shainman is a BRCA1 carrier and a previvor advocate known as BRCAresponder, an author, and a film producer behind feature film Love, Danielle.

My advocacy started from frustration.

I help people better understand hereditary cancer and the decisions that come with it. I can’t sleep at night if I don’t.

www.ourcancerstories.com/breast-cance...

Attending SGO this year? Add "Love, Danielle" when registering! This story needed to be told and I am so grateful it is now being seen by the medical community at one of the most important women's cancer conferences of the year. www.sgo.org/events/annua...

#GynecologicOncology #BRCA

Previvorship - Final report Final project report: Social media for carriers of hereditary cancer syndromes

Final project report: Social media for carriers of hereditary cancer syndromes. @stefaniavicari.bsky.social @leverhulme.ac.uk

www.previvorship.org/final-report

#BRCA #lynchsyndrome #socialmedia #research #hereditarycancer

Father of 3 ‘Shocked’ by Rare Breast Cancer Diagnosis on 53rd Birthday, Says Regular Testing ‘Saved My Life’ (Exclusive) After discovering he carried the BRCA2 gene in 2013, one man began getting yearly mammograms. Twelve years later, he was still “shocked” to learn he had breast cancer and is now sharing his story to r...

In 2013, following a strong #familyhistory of #breastcancer, Jacob Johnson learned he was #BRCA2 +. Over a decade later, at the age of 53, the father of 3 was diagnosed with a rare & aggressive form of cancer in his right breast.

#bcsm #hereditarycancer #menshealth #genetics #patientexperience

Order a marinara pie and put your own cheese on it! 🤦‍♀️

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in BRCA Carriers 'Reassuring' data show more breast cancers with surveillance, but no difference in survival

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in #BRCA Carriers.
@medpagetoday.com

#bcsm #hereditarycancer #womenshealth #medsky #genetics

Gene-specific cancer risks in female Lynch syndrome carriers: A copula-based meta-analysis Lynch syndrome, caused by germline pathogenic variants in mismatch repair genes, markedly increases risks of endometrial, ovarian, and possibly breast…

Gene-specific cancer risks in female #Lynchsyndrome carriers.

• #Endometrialcancer is most frequent in carriers of the MSH2 & MSH6 genes.

•PMS2 & MSH6 ⬆️ #breastcancer risk; MLH1/MSH2 are associated with ⬇️ risk.

• #Ovariancancer prevalence is 6.8% without significant gene-specific effects.

Yes, this will take years of massive funding and clinical trials before it ever reaches actual treatment phase.

NYU Langone Health Announces Gastrointestinal Cancer & Translational Research Leader Dr. Anirban Maitra as New Director of Perlmutter Cancer Center NYU Langone has announced the appointment of Dr. Anirban Maitra, a pancreatic cancer researcher, as the new director of the Laura and Isaac Perlmutter Cancer Center.

NYU Langone Health announces the appointment of @anirbanmaitra.bsky.social , a preeminent physician–scientist whose work has widely influenced the field of #pancreaticcancer research, as the new director of the Perlmutter Cancer Center, an NCI designated Comprehensive Cancer Center. Congrats! 👏

Oral bacterium may promote breast cancer development and spread Researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy found that an oral bacterium commonly associated with periodontal ...

New Study by John Hopkins researchers finds Fusobacterium nucleatum can drive #DNA damage, tumor growth & metastasis, with heightened effects in cells with #BRCA1 gene mutations @eurekalert.bsky.social

#bcsm #hereditarycancer #womenshealth #medsky #cancerresearch #genetics

We can rewrite our genetic code: Best ideas of the century Our genomes are filled with errors that were once impossible to correct. But in CRISPR, we finally found an extraordinarily powerful tool for treating genetic disease – and perhaps making better versi...

www.newscientist.com/article/2510...

Pancreatic Cancer Therapy: What Comes Next? Dr Emil Lou breaks down what’s changing in pancreatic cancer care, including neoadjuvant chemotherapy, genomic testing, and why progress remains incremental.

Dr Emil Lou, medical oncologist & specialist in gastrointestinal cancers at the University of Minnesota talks about all things, updates, & advances in #pancreaticcancer , including #BRCA & #PARP therapies @medscape.com

#hereditarycancer #pancchat #medsky #genetics #pancsm

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Nature Medicine In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...

A #vaccine to prevent #coloncancer. Proof-of-concept for strong immune response and safety via neoantigens given to people with mutations for #Lynchsyndrome.

#hereditarycancer #genetics #medsky #cancerresearch

#RiseUP ☮️

Genetic tumor syndromes in female cancer: insights into inherited cancer predisposition and clinical implications - Archives of Gynecology and Obstetrics A relevant proportion of malignancies predominantly or exclusively affecting women, including breast and gynecologic cancers, is attributable to hereditary tumor syndromes, profoundly impacting cancer...

This review provides a comprehensive overview of #hereditarycancer predisposing to breast and gynecologic malignancies, with a focus on genetic basis, associated cancer risks, and implications for clinical management.

#bcsm #gyncsm #genetics #womenshealth #cancerresearch #medsky

The Angelina Jolie Effect: A Lasting Global Impact on Cancer Prevention - OncoDaily “Angelina Jolie effect”: a measurable, sustained increase in genetic testing, cancer screening, and awareness worldwide.

The Angelina Jolie Effect: A Lasting Global Impact on #BRCA #HereditaryCancer Prevention. @oncodaily.bsky.social

#bcsm #gyncsm #genetics #womenshealth #medsky #patientexperience

@epistemiccrisis via instagram is definitely worth the mention with 326K+ followers. He’s spot on & committed to intellectual honesty!! 💯 🎯

What Men Need to Know About BRCA and Other Gene Mutations | Breast Cancer Research Foundation Many of us are familiar with the BRCA1 and BRCA2 genes that, when mutated, are linked to an increased risk of breast cancer in women.…

What Men Need to Know About #BRCA & Other Gene Mutations: Get to know your #familyhistory on both sides. If inherited gene mutations are prevalent in your family, consider #genetictesting
If you’re a BRCA carrier, stay on top of breast self-exams & prostate exams.

#menshealth #genetics

No Increased Breast Cancer Risk With Menopausal Estrogen in BRCA Carriers Estrogen-only HRT tied to significantly lower risk, no adverse effect of combined hormones

No Increased #BreastCancer Risk With Menopausal Estrogen in #BRCA Carriers: Estrogen-only #HRT tied to significantly lower risk, no adverse effect of combined hormones.

Via @medpagetoday.com

#SABCS #hereditarycancer #womenshealth #bcsm #cancerresearch #medsky