Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow - Nature Aging Totani, Matsumura et al. characterize a subpopulation of aged hematopoietic stem cells with high mitochondrial mass and GPR183 expression that retain high regenerative potential, gain a selective surv...

Singapore and Japan researchers found that aged blood stem cells with high mitochondria stay regenerative, not exhausted.

They identified GPR183 as a key marker, revealing new insights into stem cell aging

www.nature.com/articles/s43...

Recycling Blood Vessels: A Breakthrough in Organ Regeneration YouTube video by Stem Cell Network - Réseau de cellules souches

(1/4) In recognition of #HeartMonth, join SCN’s Joanna Valsamis as she chats with biomedical engineering expert Dr. Sara Vasconcelos (University Health Network, Toronto) about cutting-edge stem cell research for heart disease—a leading cause of death and disability in Canada.

Generation, characterization, and validation of two human induced pluripotent stem cell lines from the peripheral blood of young and older adults Aging is a leading risk factor for the development of age-related diseases. However, how aging impacts human induced pluripotent stem cell (hiPSC) rep…

Our NIH funded lab is developing research tools for the study of biological vascular aging. One tool is the development of pluripotent stem cells from young and older adults’ peripheral blood.
Here’s some of our recent work: www.sciencedirect.com/science/arti...

🧪 Scientists at @kidney-resrch-inst.bsky.social used human kidney #organoids to test a potential new treatment for polycystic kidney disease (PKD), a currently incurable disorder. Paper by Gulieva, Ahmadvand, & Freedman in @isscr.org Stem Cell Reports: www.cell.com/stem-cell-re...

Bacteria can anticipate the seasons: Photoperiodism in cyanobacteria Photoperiodic time measurement is the ability of plants and animals to measure differences in day versus night length (photoperiod) and use that information to anticipate critical seasonal transformat...

Long-lived plants and animals clearly regulate their physiology according to seasonal changes in day length to appropriately adjust their physiology. A new study shows that cyanobacteria can do the same even though individuals only live for a few hours. #Science

www.science.org/doi/10.1126/...

Tissue nano-transfection of antimicrobial genes drives bacterial biofilm killing in wounds and is potentially mediated by extracellular vesicles The emergence of bacteria that are resistant to antibiotics is on track to become a major global health crisis. Therefore, there is an urgent need for…

Excited to share this collaboration with @tcuellargaviria.bsky.social, @nhc-nanomedlab.bsky.social, and Dan Wozniak showing the potential of our Tissue Nano-Transfection (#TNT) technology and tissue-derived extracellular vesicles to combat biofilm infections.
www.sciencedirect.com/science/arti...

SARS-CoV-2 Envelope Protein Generates Unique Extracellular Vesicles, which appear to be an important mechanism helping SARS-CoV-2 to facilitate its spread, replicate efficiently, and evade host immune responses
https://buff.ly/4g30AHS

Structure of the flotillin complex in a native membrane environment | PNAS In this study, we used cryoelectron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flot...

So, it turns out one of our favourite extracellular vesicle lipid raft proteins, Flotillin-1 (FLOT1), is actually shaped like a basket 🧺

www.pnas.org/doi/10.1073/...

#extracellularvesicles

One can isolate #ExtracellularVesicle from🐭Bone (tibia/femur, not bone marrow)!?😮

Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭

Matrix Biol 2024
www.sciencedirect.com/science/arti...

Cryo-Et image of a brain extracellular vesicle

Benjamin Ryskeldi-Falcon’s @brfalcon.bsky.social group in the LMB’s Neurobiology Division, with Karen Duff's group at the UK DRI, have discovered that tau filaments are tethered to the membranes of extracellular vesicles in #Alzheimers

Read more: www2.mrc-lmb.cam.ac.uk/cryo-et-reve...
#LMBResearch

COVID-19 Study Links Extracellular Vesicles to Severe Outcomes - Thailand Medical News

COVID-19 Study Links Extracellular Vesicles to Severe Outcomes

www.thailandmedical.news/news/covid-1...

Ep09 (Nov 2024): rEView Insights - David Freedman and George Daaboul The rEView Podcast · Episode

This week #rEView is featuring the last #podcast in the series leading up to #ISEVxTech!

David Freedman and George Daaboul are co-founders of Everest Biolabs, specialising in workflows for #ExtracellularVesicles isolation and characterisation.

open.spotify.com/episode/3UBG...

Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens

#mBiojournal MiniReview / Mycology

journals.asm.org/doi/10.1128/...

Extracellular Vesicle Mobility in Collagen I Hydrogels Is Influenced by Matrix-Binding Integrins Extracellular vesicles (EVs) are a diverse population of membrane structures produced and released by cells into the extracellular space for the intercellular trafficking of cargo molecules. They are ...

New paper out on extracellular #vesicle (EV) mobility in #collagen I #hydrogels!
How #integrins on EV surfaces influence EV movement through tissue-like environments.

pubs.acs.org/doi/10.1021/...

Bluesky now has over 10 million users, and I was #9,738,639!