Enhorabuena, es un pedazo de paper!

My favorite paper in 2026 so far!! Absolutely stunning 🤩

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al!
link.springer.com/article/10.1...

Glad to share our new @cp-trendscellbio.bsky.social article! We discuss how repair condensates and lipid domains work together to restore lysosome integrity or deciding if it's time for lysophagy. #Lysosomes #Condensates #DamageSignature #Lipids #Ions Check it out: doi.org/10.1016/j.tc...

Find someone that loves you as much as @dgershlick.bsky.social loves RUSH!! Congrats!!

Really excited for the upcoming 93rd Harden Conference on Endosomal–Lysosomal Network Dysfunction in Neurodegeneration. The speaker lineup is fantastic and very diverse across membrane trafficking, structural biology, and functional genetics!

Especially encouraging ECRs to attend!

Thanks!

Quick proteomics question: we want to use an exogenous biotin blocking scavenger for a TurboID experiment. We tried Biolock but is very inconsistent in our hands. Does anyone have another suggestion?

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

Thrilled to share that the first part of my PhD work from @cohenlaboratory.bsky.social lab is now on bioRxiv! www.biorxiv.org/content/10.6... Check out the threads below:

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

New paper in @jcb.org! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling. It is an E3 ligase adaptor called SHKBP1, but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! @weillinstitute.bsky.social

An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!

🧪 We are excited to share this novel open access paper on Phasor Mixing Coefficient to analyze colocalization, developed by folks @i2janelia.bsky.social and @aicjanelia.bsky.social. This is also the first technical paper jointly published with our sister imaging center @malacridalab.bsky.social!

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

Excited to share a new story that transformed how we think about membrane domains in the ER!

rdcu.be/eR7Cn

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export

Wondering what’s so new and exciting? Skytorial below!

1/9

DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...

Beyond thrilled to share my PhD work out today in @natcellbio.nature.com , uncovering a nanoscale acidic environment around lysosomes that controls their mobility through proton signaling.🥳🥳🥳

Great thanks to my advisors and excellent peers for helping me！

www.nature.com/articles/s41...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

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🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

🚨 Exciting news: Ciarán Butler-Hallisse's work on microtuble turnover is out! with help from @harrisonyork.bsky.social 💪 Look at those pretty neurons 👇😀

The Reck-Peterson lab at Weill Cornell Medicine is seeking a technician or staff scientist to work on Aspergillus projects. Broad background in fungal biology and techniques required. Bioinformatics skills preferred. Find out more at: reckpetersonlab.org.

This movie shows lysosomes (orange) and keratin (gray) in a cultured cell over 10 minutes.

Pre-pore and cis pores formed by full length perforin-2 during antigen escape from early phagosomes

Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?

Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation

doi.org/10.64898/202...

Damage done, tubules on - Studying membrane damaged-induced lysosomal tubulation  - FocalPlane Damage done, tubules on - Studying membrane damaged-induced lysosomal tubulation  - Default

Grateful to @focalplane.bsky.social for inviting us to write about our last paper on lysosomal tubulation during the stress response (rupress.org/jcb/article/...)!

focalplane.biologists.com/2025/12/11/d...

A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments Communications Biology - Proximity labeling proteomics of RAB GTPases identifies an array of neighboring RAB proteins. Functional validation studies reveal links between RAB25 and DENND6A, or...

It is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!

BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...

Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...

New insights into the activation of the most elusive and (so far) the least understood human inflammasome: NLRP6 is a sensor of endolysosomal damage

Excited to announce, the 93rd Biochemical Society Harden Conference will be on "Endosomal-lysosomal network dysfunction in neurodegeneration". Come and join us in early September on the beautiful south coast of England. Lots of speaker slots available from submitted abstracts!