Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model Head injury may raise the risk of neurodegenerative disease by awakening a dormant virus.

Really interesting and particularly in light of this recent study www.science.org/doi/10.1126/...

We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, ⬆️ inflammation
www.nature.com/articles/s41...

Evaluating the evidence behind multidisciplinary roles for a multiple sclerosis unit: A systematic literature review Multiple sclerosis (MS) is a primary cause of non-traumatic disability in young adults, affecting cognitive, motor, sensory, and emotional functions. …

This is our systematic review evaluating the evidence for healthcare professionals in an MS unit www.sciencedirect.com/science/arti...

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging.

#WeekendRead! #LiveForever! Ramalingam Butler &co show @ #Science #Immunology that during #inflammaging thrombospondin-1 drives #interferon signatures & reduces detoxification pathways in hematopoietic stem cells causing loss of self-renewal, increased myeloid differentiation & systemic inflammation

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

www.nature.com/articles/s41... —Hasegawa et al answer why joint synovium is prone to systemic inflammation and pain. identified a specific type of capillary in joints of mice that forms permeable blood–joint barrier connecting macrophage and nocioceptive neurons #RheumSky #ImmunoSky

Natural killer loops: pyruvate in, lactate out - Nature Metabolism Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD+ via ...

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells.

#immunology #NKcells #Immunometabolism

doi.org/10.1038/s422...

See our commentary article here:

www.nature.com/articles/s42...