Flyer describing the Small GTPase conference, register at this URL: https://events.faseb.org/event/Small-GTPases/summary

1 week left to submit an abstract to be considered for a talk at the FASEB GTPase conference:

events.faseb.org/event/Small-...

What if you could cut out sub cellular structures and measure the proteome? SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection
www.biorxiv.org/content/10.6...
awesome work by Curdin Franziscus, @imcf-lex.bsky.social,
@biehli.bsky.social, Alexander Schmidt!

We miss you!

Check out our new paper on mRNA levels + P-body condensate properties. Congrats to Debdatto Mookherjee and Madeleine Rommel, super collaboration with
@mariahondele.bsky.social ,FerdinandWeidner, Matej Siketanc
Non-translated mRNA levels determine P-body properties www.biorxiv.org/content/10.6...

Spang Lab's snowshoeing and sledging event. What a gorgeous day in amazing company!

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...

Happy that we could contribute to this exciting paper from the @spanglab.bsky.social!

Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans Nature Communications - Kyriakakis et al. show that bacterial RNA can improve C. elegans healthspan and reduce toxic protein aggregation in muscles. This depends on inter-tissue communication and...

A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author!
@unibas.ch
@natcomms.nature.com
@snsf.ch
#Longevity #healthspan
rdcu.be/eI1vZ

We are thankful to our collaborators from the @spanglab.bsky.social and @maierlab.bsky.social @biozentrum.unibas.ch @unibas.ch

It was our great pleasure to be part of this exciting project!

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity Nature Communications - Antisense oligonucleotide (ASO) cellular activity requires endosomal escape. Here, the authors show that disrupting Golgi-endosome protein AP1M1 enhances ASO activity by...

Great collaboration with Liza Malong and Filip Roudnicky from pRED @Roche rdcu.be/et6Nw

Anne Spang awarded distinction of AAAS Fellow The AAAS has elected Prof. Anne Spang at the Biozentrum, University of Basel, as a Fellow. With this honor, the world’s largest scientific society recognizes her outstanding contributions to the field...

Congratulations to Anne Spang @spanglab.bsky.social for being elected as a new #AAASFellow by @aaas.org ! The world’s largest scientific society recognizes her outstanding contributions to the field of cell #biology and #biochemistry. @unibas.ch
www.biozentrum.unibas.ch/news/detail/...

We got the cover!!! Check out our new story in EMBO J. #endosomes #c.elegans #membranes #GTPases

Awesome lab outing: snow shoeing and sledding! Thank you for being such a wonderful team!

Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal imageimageEarly endosome maturation requires Rab conversion and ESCRT function; however, how these processes are coordinated remains largely elusive. This study proposes that Rab conversion in both C....

Interested how events are coordinated during #endosome maturation? Check out our latest paper! Congrats Daniel, Samit and Jachen!
www.embopress.org/doi/full/10....

So let’s do some super science together!!

I feel humble and honored to receive the Lelio Orci Award 2024. I want to thank my amazing co-workers and trainees who are with me on the pursuit of the understanding how intracellular communication is achieved.

Me!