@biorxivpreprint.bsky.social Type 1 and type 2 dendritic cell subsets cooperate to maintain intestinal immune tolerance via integrin αvβ8-mediated TGF-β activation
www.biorxiv.org/content/10.6...

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and ...

γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight

#gdTcells @bsilvasantos.bsky.social

TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function The human TCRγδ constant region modulates T cell activation and corresponds with T cell clonal expansion and function.

The human TCRγδ constant region modulates T cell activation and corresponds with T cell clonal expansion and function @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

@biorxivpreprint.bsky.social Immune cells adapt to distinct stem cell niches to govern tissue homeostasis
@rockefeller.edu
www.biorxiv.org/content/10.6...

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice - Nature Communications Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meni...

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice

#gdTcells @natcomms.nature.com

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis @natimmunol.nature.com
www.nature.com/articles/s41...

"I learned that everyone is slightly panicked (include me for the presentation)" hahaha. Thank you for sharing these thoughts!!

What a wonderful text, Payal. I have to say that I directly identified with two parts: "although my talk was only okay, the experience made me feel seen and connected to the community" (I felt exactly like that and even more motivated) and …

Thank you so much ☺️

So inspiring 👏🏽👏🏽👏🏽

The unparalleled @bsilvasantos.bsky.social concludes the amazing #gammadeltatoronto with the keynote talk. A moment I've waited for since may2022 inaugural #gdtcellclub talk.

Super excited to see the wrap up for the unbelievable conf thanks to JC and the other fellow organizers.

Let's go!!

Join us for the 11th Intnl #GDTcells conf in Toronto (May 20-23) as we celebrate emerging research and inspire future directions. I will be wearing two hats: conf organizer and repping #GDTcellclub w/ @eberlmat.bsky.social. Pls come say hi! @forum-gd.bsky.social
na.eventscloud.com/website/7048...

Drs @juliosds1.bsky.social & Herbert Leonel de Matos Guedes review #γδTcells in #leishmaniasis: intrinsic factors & outcomes. #Leishmania #Lipophosphoglycan #IL17 #Neutrophil #IFNγ@ufrjoficial.bsky.social @oficialfiocruz.bsky.social

authors.elsevier.com/a/1ktAi5Eb1x...

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation - Nature Immunology Here, the authors use a double-reporter system to tag IFNγ-producing versus IL-17A-producing γδ T cells to compile a trancriptomic resource of these cell subsets in mice at steady state and in respons...

Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation

#gdTcells @natureportfolio.bsky.social

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

Some immune cells fuel the fire of disease, while others help put it out—finding the balance could change treatments.

@juliosds1.bsky.social

t.co/8HpBNRQ9Wv
#ImmunoSky 🧪

Now in my postdoc, I can’t wait to uncover the mysteries of γδ T cells in the gut with the incredibly motivating group of Prof. @BSheridanLab . I’m beyond excited for what’s to come! #Postdoc #Immunology #Research”

IL-17A/IFN-γ producing γδ T cell functional dichotomy impacts cutaneous leishmaniasis in mice Under steady-state conditions, γδ T cell expansion is minimal; however, upon infection with L. amazonensis, there is a marked increase in IL-17-producing γ

I’m proud to finish my PhD story on a high note. My paper is now published @jlb_journal , where we highlight the IL-17/IFN-γ dichotomy in γδ T cells during L. amazonensis infection. #gdTcells #LoveStory #Science

academic.oup.com/jleukbio/adv...

🙋🏽‍♂️

Elotuzumab‐mediated ADCC with Th1‐like Vγ9Vδ2 T cells to disrupt myeloma–osteoclast interaction Signaling lymphocytic activation molecule family 7 (SLAMF7), an important therapeutic target of myeloma cells, is highly expressed in osteoclasts. Ex vivo-expanded human Vγ9Vδ2 T cells are able to ef...

Elotuzumab-mediated ADCC with Th1-like Vγ9Vδ2 T cells to disrupt myeloma–osteoclast interaction

#gdTcells #ImmunoSky

onlinelibrary.wiley.com/doi/10.1111/...

Please join us for our November #GDTcellclub #gdTcells webinar with talks by Drs. Pamela Ohashi and Anna Ruta.

Nov 21 @ 12pm (New York) | 5pm (London)

mit.zoom.us/j/9351906959...
Zoom ID: 935 1906 9595
Passcode: 292773

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

Coffee-associated beneficial health effects could be due to its influence on intestinal Lawsonibacter asaccharolyticus abundance.

☕️ ☕️ ☕️

www.nature.com/articles/s41...

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