Now in Cancer Discovery @aacrjournals.bsky.social: Senescent CAFs Drive Early-Stage Lymph Node Metastasis in PDAC via Lactate-mediated Metabolic-Epigenetic Rewiring - by Tianxing Zhou, Jingrui Yan, Jun Yu, Yukuan Feng, Rui Liu, Yongjie Xie, Bin Wang, Jihui Hao, et al. doi.org/10.1158/2159...

Congrats Costas and team!! Nice work!!

Do metabolic fluxes change with age? Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.

Online Now: Do metabolic fluxes change with age? #trends #endocrinology #metabolism

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

Registrations for ISCaM 2026 Meeting are finally open!!
Join us in Padua (IT) on September 21-23 for science, networking, fun!!
Low registration fees, plenty of slots for selected abstracts, travel grants, splendid location, social activities on top of a stellar lineup of speakers!

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

New paper out in Nature Communications:
www.nature.com/articles/s41...
We found >250 metabolic enzymes on chromatin.
Only ~20 had been reported before.
This means hundreds of metabolic enzymes may have unexplored nuclear roles.

Now online in Cancer Discovery @aacrjournals.bsky.social: Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis - by Xiao-Zheng Liu, Mariia Yuneva, Sarah-Maria Fendt, and colleagues doi.org/10.1158/2159... @crick.ac.uk

That is my sense too

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇

What to know more? Join ISCaM2026!!!

iscam2026.azuleon.org

Interested in nutrient sensing or the relationship between nutrient availability and cancer?
Look no further than ISCaM2026
Registrations open March 2nd

Perks include a vibrant, young environment, a friendly community operating year-round, lots of fun social activities, a paper writing workshop by senior profs and editors, and all that is CHEAP

Interested in nutrient sensing or the relationship between nutrient availability and cancer?
Look no further than ISCaM2026
Registrations open March 2nd

Please share with your colleagues but especially with talented trainees that can benefit the most from the friendly-yet-exciting environment of the ISCaM community

And most importantly it’ll be a great opportunity to meet people, discuss science and have fun while doing what we love to do

Dear metabolism lovers, friends… have a look at this year ISCaM meeting that will be hosted in my beautiful Padua.
It features a terrific lineup of speakers, plenty of slots for selected talks, several travel grants #ISCaM2026

Today the Italian Pancreatic Cancer Community will host @clausjorgensen.bsky.social for an exciting webinar on TME heterogeneity. Free to join!!!

Excited to announce that registration is officially open for #METPHYS2026!

All meeting details can be found here:
www.sablesys.com/metphys-the-...

They should buy coffee and more to every reviewer

Thanks Jason!! I hope people would read it!!

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

On this date in 1751, what would eventually become the University of Pennsylvania opened its doors in a building on Fourth Street for the first time. This marked an early moment in a history that now celebrates its 275th anniversary.

Read more about Penn’s first campus: https://bit.ly/4gIpLA8

Mouse pancreas epithelial cells with mutant RAS – have prominent nucleoli that sometimes arrange to make little smiley faces

📹 @zeinabrekad.bsky.social @oxfordbiochemistry.bsky.social. At the Dept's imaging facility Micron with @leicamicrosystems.bsky.social THUNDER
➡️ bpod.org.uk/archive/2025...

1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells - The EMBO Journal Oxidative stress is a major driver of cardiovascular disease; however, the fast changes in cellular metabolism caused by short-lived reactive oxygen species (ROS) remain ill-defined. Here, we characte...

link.springer.com/article/10.1...

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

Anybody got an example of substrate channeling where an isotopic label in a specific product is more enriched than the tracer? I know this is theoretically possible with compartmentalized pools but I am drawing a big old blank on relevant literature?

There is still time for @biochemsoc.bsky.social members to apply for funding for @febsjuniorsection.bsky.social Young Scientist's Forum happening in the Nertherlands in July 2026. Attendance will be supported through funds to support registration, travel and accommodation. Deadline is 10th December

Thanks Christian

kudos to both Anna's and my team who did the heavy lifting. We showed that pancreatitis-associated ER stress lead to NPC1 degradation and cholesterol sequestration within lysosomes. Read it to find the impact for disease pathogenesis!!

An idea seeded by talks with @robzonculab.bsky.social
and spontaneous collaborative work with Anna at UCLA. A true example of the positive power of human connection in science